Sentences with phrase «cell disease progresses»

When sickle cell disease progresses, it can delay puberty and cause acute and chronic complications, including debilitating pain, life - threatening infections, damage to vital organs, and stroke.

Not exact matches

By treating biology as software and reprogramming cells to treat diseases and other ailments, humans have already made tremendous progress in medicine, Kurzweil said Sunday.

Donepezil (Aricept) can slow the progress of mild to moderate Alzheimer's disease by blocking the breakdown of acetylcholine, a neurotransmitter that carries messages between nerve cells.

The trial enrolled 361 patients with recurrent or metastatic head and neck squamous cell carcinoma who had not responded to platinum - based chemotherapy, a rapidly progressing form of the disease with an especially poor prognosis, said Dr. Ferris.

For the new trial, hospitals enrolled patients with advanced, squamous non-small cell lung cancer whose disease had progressed despite initial chemotherapy.

This unexpected result suggests that mutations in NPM1 behave as gatekeepers for this cancer; once a mutation in this gene occurs in a cell with particular previously accumulated pre-leukaemic mutations, the disease progresses rapidly to become leukemia.

But scientists are making progress in refining these therapies, and the first ever trial of fetal stem cells injected directly into the brain is currently under way in children with Batten disease, a rare and fatal illness of the nervous system.

According to this theory, tumor cells tend to «forget» the tissue from which they originated as the disease progresses, acquiring an undifferentiated phenotype associated with heightened aggressiveness and treatment resistance.

As prostate cancer progresses, tumor cells may infiltrate this periprostatic adipose tissue: this is a key step in the progression of this cancer, as it signals locally advanced disease (where the cancer can progress to nearby organs).

New products and developments, such as new drugs for cancer, fresh therapies for rare diseases, progress in medications for HIV / AIDS, and advances in stem cell research had the greatest positive impact.

Genetically reprogramming late - stage human cancer cells to a stem - cell state enabled them to force the reprogrammed cells to progress to an early cancerous state, revealing secreted blood biomarkers of early - stage disease along the way.

On the other hand, the emergence of new products such as drugs for cancer, HIV / AIDS, and rare diseases, as well as progress in stem cell research, are strong positives in the industry's favor.

These include the ability to bring new, innovative products to the market; progress in oncology, such as the approval of Genentech's drug Avastin for breast cancer and advances in the use of gene therapy, despite some setbacks; continuing progress in research on stem cells; the emergence of treatments for previously untreated diseases; and solutions for food and fuel shortages, such as biocrops and biofuels.

As a result, they can now test drugs directly on living cells afflicted with the disease, and they can accurately model how it progresses.

In the longer term, these methods could hasten progress toward replacing a damaged or diseased kidney with tissue derived from a patient's own cells.

Certain conditions affect one sex more than the other, he notes, so «if the genetics of a cell affects the progress of a disease, it might suggest specific causes or treatments for disease.»

«Investigators create complex kidney structures from human stem cells derived from adults: New technique offers model for studying disease, progress toward cell therapy.»

«Then we let the atherosclerosis develop and progress [in mice] in order to see where those cells were later in disease.»

«This study represents our progress towards making airway spheres from any patient with a lung disorder and learning about that patient's disease from those cells.

Items worthy of mention in this context include new drugs for cancer, new therapies for rare diseases, progress in HIV medications, and stem cell research.

The team is now working with doctors at Massachusetts General Hospital, who hope to use the new, noninvasive technique to study cells involved in cancer, asthma, and other conditions in which cell properties change as a disease progresses.

In 2017, a steady stream of encouraging clinical results showed progress in gene therapies for hemophilia, sickle - cell disease, blindness, several serious

Cancer tumours manipulate a natural cell process to promote their survival suggesting that controlling this mechanism could stop progress of the disease, according to new research led by the University of Oxford.

Stages of fatty liver disease: A healthy liver (1) can progress to fat accumulation (2) and then to NASH, which features inflammation (3), cell swelling (4), and sometimes scarring (5).

Additionally, a form of indolent B cell lymphoma, which progresses slowly with only mild symptoms, can transform without warning into an aggressive form of the disease.

This implant makes use of bipolar cells, as these form the second layer downstream of photoreceptor cells lost to the progress of disease.

The therapy is approved by the U.S. Food and Drug Administration for relapsed or treatment - resistant Hodgkin lymphoma, and it is commonly prescribed to patients whose disease has progressed after autologous stem cell transplant, a procedure that replenishes the bone marrow with the patient's own healthy stem cells after therapy.

Of these 34 patients, 13 (38 %) have remained in remission for five years, and an additional two patients whose disease did not progress after BV went on to achieve remission after receiving allogeneic stem cell transplant (in which healthy stem cells are taken from a donor and administered to the patient).

The FDA granted accelerated approval to nivolumab (Opdivo), an anti-PD-1 checkpoint inhibitor, for patients with classical Hodgkin lymphoma (cHL) whose disease has relapsed or progressed after stem cell transplantation and the targeted antibody brentuximab vedotin (Adcetris).

The Zeng lab is making great progress on developing a stem cell - derived treatment for Parkinson's disease for testing in humans.

In fact, while Islet cell autoantibodies, or IA, are considered a red flag for type 1 diabetes, not every child with IA will progress to full - blown disease, She says, although multiple autoantibodies definitely increase that risk.

Its impairment is closely associated with the process of aging, the progress of neuro - degenerative and neuro - muscular diseases and cell death.

Understanding the functions of lipids and cell membranes is key to progress in basic cell and tissue biology as well as in the many diseases that are caused by lipid dysfunction.

This would be really important if it worked in humans for type 2 diabetics that are slowly losing beta cells as the disease progresses.

Our increased understanding in areas such as stem - cell biology, human immune systems, and identification of disease - specific biomarkers all have contributed significantly to that progress.

By sweeping away AS aggregates before they get a chance to spread, AS immunotherapies have the potential to hold the nonmotor symptoms of PD at bay, slowing the overall progress of the disease, and — when combined with mature cell therapy — eventually preventing the disease altogether, and potentially even reversing it.

While investments in stem cell research will generate some financial return for the state of California, the primary benefits from these investments will be progress toward improved therapies for the treatment of major chronic and acute diseases.

The knowledge about how this cancer form arises and develops is still limited but new results from a research team led by Lene Uhrbom, Uppsala University / SciLifeLab, shows that disease progress and the malignancy are affected by the cell type from which the tumor originates as well as the age of the patient.

HHMI investigator Arul Chinnaiyan and colleagues at the University of Michigan showed that as prostate cancer develops and progresses, sarcosine levels increase in both tumor cells and urine samples, suggesting that measurements of the metabolite could aid in non-invasively diagnosing the disease.

And those cells degenerate and eventually die as the disease progresses.

As the disease progresses, MDS blood cells continue to accrue DNA abnormalities, suggesting that faulty DNA repair mechanisms plays a role in MDS development.

Thomas M. Brunner: The Glaucoma Research Foundation is bringing together a second team of scientists to look for markers that can tell when the cells first get ill and how the disease progresses.

Advances in cell therapy have resulted in significant progress toward treating some widespread and difficult diseases, many of which represent unmet medical needs.

An additional goal of the partnership is to use patient - derived cells in Organ - Chips to make progress with strategies for personalized drug safety and allow a new approach to augment the prediction of disease or treatment variation between individuals.

Conversely, adult stem cells are showing great progress in applications dealing with major diseases.

Today, this study presents tangible progress for patients with a devastating genetic brain disease and opens the door for application to other neurological diseases that are treatable with hematopoietic stem - cell transplantation.

NASH can eventually progress to end - stage liver disease known as cirrhosis, wherein damaged liver cells die off and are replaced by scar tissue that impairs function that can lead to liver failure or liver cancer.

However, as the disease progresses, the pancreatic beta cells, which make insulin, become impaired and patients may eventually need insulin injections.

In terms of fat - derived stem cells, progress has been made in several areas of canine health, including muscle inflammation and a disease known as immune - mediated anemia, which is when the immune system destroys red blood cells, leaving your dog weak and listless.

Blood samples tested early in the disease are always low in certain white blood cells (lymphopenia) but the number may go up as the disease progresses.