Sentences with phrase «cell disease significantly»

They found that sickle cell disease significantly increases S1P and that S1P is generated by sphingosine kinase 1 (SphK1).

Not exact matches

New technology that transforms a cell phone into a powerful, mobile microscope could significantly improve malaria diagnoses and treatment in developing countries that often lack the resources to address the life - threatening disease, says a Texas A&M University biomedical engineer who has created the tool.

Mice without Del - 1 that had been induced to get EAE also had significantly higher numbers of inflammatory cells in their spinal cords at the disease's peak, a fact that further experiments revealed was due to increased levels of the signaling molecule IL - 17.

A molecule that helps cells stick together is significantly over-produced in two very different diseases — rheumatoid arthritis and a variety of cancers, including breast and brain tumors, concludes a new study.

Furthermore, an immunological analysis found that the level of TH1 cells, characteristically expressing interferon - gamma protein which activates microphage to enhance bactericidal activities but could be an onset of autoimmune diseases when excessive, significantly increased in some of the mice.

Now Prof. Daniel Offen and Dr. Adi Shruster of Tel Aviv University's Sackler School of Medicine have discovered that by reestablishing a population of new cells in the part of the brain associated with behavior, some symptoms of Alzheimer's disease significantly decreased or were reversed altogether.

Researchers from the University of Miami, Florida and the Universitat Autònoma de Barcelona have developed a method which allows to drastically reduce the drug dose, since it improves its efficacy 83 %, multiplies by 10 the capacity of the drug to attack cell infected by the parasite which provokes the disease, and significantly reduces the toxicity of the parasite.

«The amount of spermine in the cells of the hippocampus was significantly reduced in diseased animals as compared to the healthy animals,» report the lead authors Dr. Michel Royeck and Dr. Thoralf Optiz from Dr. Beck's team.

Intriguingly, brain cells (neurons) with decreased complex I levels are significantly less likely to contain Lewy bodies, the abnormal protein - aggregates that characterize Parkinson's disease,» says researcher Charalampos Tzoulis at Department of Clinical Science, UiB.

However, compelling evidence suggests that accumulation of amyloid aggregates in the islets of Langerhans might significantly contribute to β cell dysfunction and disease (Hull et al., 2004; Haataja et al., 2008; Jurgens et al., 2011; Mukherjee et al., 2015).

Our increased understanding in areas such as stem - cell biology, human immune systems, and identification of disease - specific biomarkers all have contributed significantly to that progress.

The results showed that the mutational spectrum of these genes in PTCL - NOS was similar to that in B - cell lymphoma, in which predominantly missense mutations were found.17, 18 Importantly, our study provided clinical evidence that histone modifier gene mutations, particularly those involved in histone methylation and acetylation, are significantly associated with tumor chemoresistance and disease progression of PTCL - NOS.

Polymorphisms in five of 15 genes (33 %) encoding molecules known to primarily influence pancreatic beta - cell function - ABCC8 (sulphonylurea receptor), KCNJ11 (KIR6.2), SLC2A2 (GLUT2), HNF4A (HNF4alpha), and INS (insulin)- significantly altered disease risk, and in three genes, the risk allele, haplotype, or both had a biologically consistent effect on a relevant physiological trait in the QT study.

These 45 variants are significantly enriched for protein - coding changes (n = 13), direct disruption of transcription - factor binding sites (n = 3), and tissue - specific epigenetic marks (n = 10), with the last category showing enrichment in specific immune cells among associations stronger in Crohn's disease and in gut mucosa among associations stronger in ulcerative colitis.

Antioxidants work by significantly slowing or preventing the oxidative — or damage from oxygen — process caused by substances called free radicals that can lead to cell dysfunction and the onset of problems like heart disease and diabetes.

Antioxidants work by significantly slowing or preventing the oxidative — or damage from oxygen — process caused by substances called free radicals that can lead to cell dysfunction and the onset of problems like heart disease and diabetes, but also of the inflammation underpinning psoriasis.

«What we have to recognize... is that if cancer is a mitochondrial metabolic disease and you get cancer because of mitochondrial failure in certain populations of cells and certain tissues, if you prevent your mitochondria from entering into this dysfunctional state... [then] the probability of getting cancer is going to be significantly reduced.

Now, just - published research supports the ability of quercetin — a plant compound — to not only suppress the growth of pancreatic cancer cells, but to help significantly reduce the risk of developing the disease in the first place.

A more recent publication from U.C. Davis (de la Riva, Hart et al, 2013) looked at two joint disorders and three cancers — hip dysplasia, cranial cruciate ligament tear, lymphosarcoma, hemangiosarcoma and mast cell tumor — and showed that, for all five diseases analyzed, the disease rates were significantly higher in both males and females that were neutered either early or late compared with intact (non-neutered) dogs.