Sentences with phrase «cell disease since»

St. Jude has been committed to treating and curing sickle cell disease since its opening in 1962.

Not exact matches

Since its foundation in 2005, the NYSCF has become a leader in using stem cell research and technology to find cures for a range of diseases, from heart disease and diabetes to Alzheimer's and Parkinson's.

research; since most of the reports have concentrated on justifying the creation of cloned human embryos for research into and treatment of neurodegenerative diseases such as Parkinson's, «stem - cells» has become synonymous with «embryonic stem - cells» in the public imagination.

Since celiac disease is, according to the New ENgland Journal of Medicine, a complex auto - immune disease triggered by exposure to gluten, and auto - immune disease are very, very rarely curable, I don't do anything that will increase antibodies against my own cells.

These unformed stem cells have the ability to turn into mature blood cells — and could save the life of someone who needs a bone marrow transplant, and possibly other diseases, since stem - cell research remains in its infancy, really.

My daughter's and my diagnosis with a Mast Cell Disorder has lead me to do some research into mast cell disorders and how they relate to these other diseases, especially since my daughter also has tree allergies, celiac disease and ADHD; I have EoE, environmental and other severe food allergies; and my son has a diagnosis of multiple life threatening food allergies, eczema, environmental allergies and astCell Disorder has lead me to do some research into mast cell disorders and how they relate to these other diseases, especially since my daughter also has tree allergies, celiac disease and ADHD; I have EoE, environmental and other severe food allergies; and my son has a diagnosis of multiple life threatening food allergies, eczema, environmental allergies and astcell disorders and how they relate to these other diseases, especially since my daughter also has tree allergies, celiac disease and ADHD; I have EoE, environmental and other severe food allergies; and my son has a diagnosis of multiple life threatening food allergies, eczema, environmental allergies and asthma.

Since the first human brain organoids were created from stem cells in 2013, scientists have gotten them to form structures like those in the brains of fetuses, to sprout dozens of different kinds of brain cells, and to develop abnormalities like those causing neurological diseases such as Timothy syndrome.

Since pseudouridine modifications may affect various RNA molecules in different types of normal and malignant cells, «our discoveries pave the way for future avenues of research aimed at exploring the role of pseudouridine in human development disease,» concludes Cristian Bellodi.

A decade ago, he replicated the entire human leukemia disease process by introducing oncogenes into normal human blood cells, transplanting them into xenografts (special immune - deficient mice that accept human grafts) and watching leukemia develop — a motherlode discovery that has guided leukemia research ever since.

Their findings, published online this week in the journal Cell Reports, have implications for the continued development of therapeutics to treat Ebola virus disease, which has claimed the lives of over 11,000 people in West Africa since last year.

Since many human diseases can be explained by perturbations of molecular interactions within cells, interactomes will drastically change how we think about human health, and how we set about designing drugs and preventive measures to counter illness.

Porter will also monitor the patients» long - term health; since they lack healthy B cells, they may require lifelong immunoglobulin to help resist other cancers, immune disorders, and infectious disease.

For his part, Collins, who has led NIH since 2009 and been kept on by the Trump administration, pointed to an array of promising NIH activities, including the development of new technologies to provide insights into human brain circuitry and function through the Brain Research through Advancing Innovative Neuroethologies (BRAIN initiative) and the use of the gene - editing tool CRISPR - Cas9 to correct mutations and clear the way to develop and test a «curative therapy» for the first molecular disease: sickle cell disease.

«Stress response networks control the life vs. death decision in cells, and since a diseased cell is nowhere near its comfort zone, rewiring its stress responses allows it to avoid or delay cell death even when conditions are adverse.

But the disease has other means of creating havoc in cells, researchers have since found.

Since embryonic stem cells can differentiate into any type of tissue, they have the potential to treat an almost unending array of medical conditions — replacing damaged or lost body parts or tissues, slowing degenerative diseases, even growing new organs.

The stroke was just one complication of sickle - cell anemia, the hereditary disease that has haunted her since infancy.

Since Lipton's group co-discovered the SNO reaction some 20 years ago, scientists have linked the reaction to protein misfolding and nerve cell damage in cases of Alzheimer's, Huntington's, amyotrophic lateral sclerosis (ALS / Lou Gehrig's disease) and Parkinson's disease, as well as heart / cardiovascular disease and cancer.

It has been 8 years since an astonishing observation persuaded many scientists that the misfolded protein implicated in Parkinson's disease spreads from brain cell to brain cell, like an infection.

Since the late 1990s, researchers have been trying — and mostly failing — to accomplish this in type 1 diabetes, an immune disease that destroys cells in the pancreas that make insulin and that mostly strikes children.

«There was some skepticism about whether a CD19 - directed therapy would work in this disease, since nearly all of these patients» cancerous plasma cells do not express CD19,» said the study's senior author, Edward Stadtmauer, MD, chief of Hematologic Malignancies and a professor of Hematology / Oncology in Penn's Abramson Cancer Center and Perelman School of Medicine.

Since these cells give rise to the immune system, what about using them to treat autoimmune diseases?

Researchers from the University of Miami, Florida and the Universitat Autònoma de Barcelona have developed a method which allows to drastically reduce the drug dose, since it improves its efficacy 83 %, multiplies by 10 the capacity of the drug to attack cell infected by the parasite which provokes the disease, and significantly reduces the toxicity of the parasite.

Thought to play a large role in cell - to - cell communication and disease transmission, they have been objects of scientific curiosity since their discovery three decades ago.

The deck was stacked in favor of success in the choice of this particular disease since it was known that the therapeutic gene just had to be expressed in a modest number of blood cells to achieve therapeutic benefit.

«Since MCR works by targeting specific DNA sequences, in cases where diseased cells have altered DNA as in HIV - infected individuals or some types of cancer, MCR - based methods should be able to distinguish diseased from healthy cells and then be used to selectively either destroy or modify the diseased cells.»

In a relatively short period since its foundation in 2002, the CRG has generated important scientific insights in our understanding of the organization, deployment and evolution of genetic information, the internal workings of cells, their differentiation and reprogramming, their collective organization to form tissues and their alterations in disease, including cancer.

Since then he has continued to investigate new strategies to overcome the major hurdles to safe and effective gene transfer, translate then into new therapeutic strategies for genetic disease and cancer, and allowed new insights into hematopoietic stem cell function, induction of immunological tolerance and tumor angiogenesis.

«Since that time, Lorenz has made a significant number of transformative contributions and developed protocols that have fundamentally changed the way we create stem cells in the lab,» said Lennart Mucke, MD, director of the Gladstone Institute of Neurological Disease.

Our understanding of these cells and their incredible potential for treating diseases, fight cancers, heal wounds, and, in essence, saving lives, has grown hugely since we first unknowingly used them in World War II.

Since the recent discovery of tremendous biological effects of nitric oxide, other small gaseous molecules such as carbon monoxide or hydrogen sulfide have emerged to be similarly important in cell signaling, with a great impact on pathophysiology of various diseases.

Health improvement (allowing to post - pone / escape the diseases and thus live, healthier / disease - free longer, but not above human MLSP of around 122 years; thus these therapies do not affect epigenetic aging whatsoever, they are degenerative aging problems not regular healthy aging problem (except OncoSENS - only when you Already Have Cancer - which cancer increases epigenetic aging, but cancer removal thus does not change anything / makes no difference about what happens in the other cells / about what happens in the normal epigenetic «aging» course in Normal non-cancerous healthy cells) Although there is not such thing as «healthy aging» all aging in «unhealthy» (as seen from elders who are «healthy enough» who show much damage), it's just «tolerable / liveable» enough (in terms of damage accumulating) that it does not affect their quality of life (enough yet), that is «healthy aging»: ApoptoSENS - Clearing Senescent Cells (this will have great impact to reduce diseases, the largest one, since it's all inflammation fueled by the inflammation secretory phenotype (SASP) of these senescent cells) AmyloSENS - Dissolving the Plaques (this will allow humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their age), and both are correlated to Mcells / about what happens in the normal epigenetic «aging» course in Normal non-cancerous healthy cells) Although there is not such thing as «healthy aging» all aging in «unhealthy» (as seen from elders who are «healthy enough» who show much damage), it's just «tolerable / liveable» enough (in terms of damage accumulating) that it does not affect their quality of life (enough yet), that is «healthy aging»: ApoptoSENS - Clearing Senescent Cells (this will have great impact to reduce diseases, the largest one, since it's all inflammation fueled by the inflammation secretory phenotype (SASP) of these senescent cells) AmyloSENS - Dissolving the Plaques (this will allow humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their age), and both are correlated to Mcells) Although there is not such thing as «healthy aging» all aging in «unhealthy» (as seen from elders who are «healthy enough» who show much damage), it's just «tolerable / liveable» enough (in terms of damage accumulating) that it does not affect their quality of life (enough yet), that is «healthy aging»: ApoptoSENS - Clearing Senescent Cells (this will have great impact to reduce diseases, the largest one, since it's all inflammation fueled by the inflammation secretory phenotype (SASP) of these senescent cells) AmyloSENS - Dissolving the Plaques (this will allow humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their age), and both are correlated to MCells (this will have great impact to reduce diseases, the largest one, since it's all inflammation fueled by the inflammation secretory phenotype (SASP) of these senescent cells) AmyloSENS - Dissolving the Plaques (this will allow humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their age), and both are correlated to Mcells) AmyloSENS - Dissolving the Plaques (this will allow humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their age), and both are correlated to MLSP).

It should be noted, however, that while a study on senescent cell ablation in genetically normal mice would provide at least some evidence on the effect of senescent cells (and their ablation) on promoting cancer, even such a study would likely show less effect than could be anticipated in a large mammal model, since even normally - aging mice rarely suffer metastatic disease to the extent of aging humans, as sheer primary tumor volume is generally sufficient to be fatal to mice.

Since 1997, he has directed the investigation of neurodegenerative diseases in the Nurses» Health Study and other large cohorts comprising more than 400,000 men and women who have provided detailed information on their dietary habits and lifestyle in addition to blood or cheek cell samples for genetic and other laboratory analyses.

Here we tested whether human NSCs could be reprogrammed into iPS cells utilizing a similar strategy as described above since they represent a more clinically relevant source of cells for basic studies and modeling human disease.

And since the gut microbiome plays a role in regulating tuft cells, this a rare case of antibiotics being able to impact a viral disease.

Their method, published ahead of print in the Oct. 17, 2008 online edition of Nature Biotechnology, not only provides a practical and simple alternative for the generation of patient - and disease - specific stem cells, which had been hampered by the low efficiency of the reprogramming process, but also spares patients invasive procedures to collect suitable starting material, since the process only requires a single human hair.

Since 1991, when he was diagnosed with Parkinson's disease (a degenerative brain disorder that affects movement), actor Michael J. Fox has been a vocal proponent for stem cell research.

«Since these cells drive inflammatory disease, our findings could suggest new therapies for conditions like allergy.»

Since actual cohesion defects will cause mitotic failure (which most surely results in cell death), most of cohesin - associated diseases are believed to be caused by misregulation of the complex's non-canonical functions in replication / transcription.

These two properties (self - renewal and pluripotency) confers human pluripotent stem cells a unique interest for clinical applications since they could allow the production of infinite quantities of cells for disease modelling, drug screening and cell based therapy.

Just like electrolyte balance needs to be maintained, the amount of sodium in our body also needs to be regulated to keep our blood pressure at just the right spot: Too high and it can increase our risk for heart disease, too low and we can feel faint since oxygen isn't getting to our cells quickly enough.

These two acids will improve the functionality of cells» membranes, especially the DHA, decrease the chances of developing a cardiovascular disease since it'll decrease oxidative stress and will relieve depression since the two acids are precursors to the feel - good hormones, dopamine, and serotonin.

The problem is, that since we've shown that cholesterol doesn't necessarily cause heart disease, and that cholesterol is necessary for cell regeneration, hormone synthesis and many other important jobs in the body, decreasing the body's ability to produce cholesterol might be (and is) the wrong approach!

Antioxidants are vital to our bodies since they help to prevent cell damage and protect against disease by mopping up destructive, unstable oxygen molecules known as free radicals.

Celiac patients may be susceptible to small bowel cancers or even lymphoma, since immune cells are also affected, thanks to the inflammation caused by celiac disease.

I have a nut question — since fat hinders insulin's job of getting glucose into the cells, which can lead to insulin resistance, prediabetes and diabetes, should people who have these diseases refrain from consuming nuts?

Many claims have been made about olive oil as well, but the fact of the matter is, all oils cause epithelial cell damage to your blood vessels which causes a marked increase in your risk for heart disease since the protective cell layer can no longer clear up blockages.

And since energy overload is toxic to our cells and predictive of many disease states (diabetes, inflammatory conditions, etc) having more mitochondria on hand will keep you healthier for longer.

Since celiac disease is, according to the New ENgland Journal of Medicine, a complex auto - immune disease triggered by exposure to gluten, and auto - immune disease are very, very rarely curable, I don't do anything that will increase antibodies against my own cells.