Sentences with phrase «cell disease through»

Novo Nordisk has moved into sickle cell disease through a licensing deal (PDF) with EpiDestiny.

Not exact matches

Now comes word of another moonshot project from the company's Google X division: an ingestible disease - detecting pill containing thousands of microscopic magnetic particles that course through a person's bloodstream in search of malignant cells, according to the Associated Press.

He was featured last April in a segment that included Michael J. Fox - who suffers from Parkinson's disease and is an avid supporter of foetal stem - cell research through his charitable foundation.

All have had injections of specialised retinal cells in their eyes to replace ones lost through age or disease.

TANGLED proteins that strangle brain cells from within seem to be what allows Alzheimer's disease to spread through the brain.

«This research represents an important step toward the goal of being able to better treat thyroid diseases and being able to permanently rescue thyroid function through the transplantation of a patient's own engineered pluripotent stem cells,» explained co-corresponding author Anthony N. Hollenberg, MD, Chief of the Division of Endocrinology, Diabetes and Metabolism at BIDMC and Professor of Medicine at Harvard Medical School.

The advantages of MFCs may allow widespread use of diagnostic procedures that are currently too expensive to implement (e.g., prescreening for cancer) while the new capabilities may dramatically improve our ability to understand complex diseases such as cancer (e.g., through single - cell analysis).

If this environment is harmed by chemicals, such as through damage to gut cells, it could impact the health of the organisms and would lead to a number of fish diseases but this technique will enable us to increase the tests we can carry out and improve our understanding of how to preserve gut health.»

«Our immune system is made up of specialised cells that move through blood and tissue, preventing disease and fighting infection by distinguishing between what is the body's own healthy tissue and what is foreign.

«We need to design nanoparticles that will, like a lock - and - key mechanism, travel through the body and interact only with the diseased cell surface,» says Marth.

During the active disease stage of JIA, these cells expand, grow in number, re-circulate through inflamed areas of patients» body, and migrate to the connective tissue of patients» joints.

For his part, Collins, who has led NIH since 2009 and been kept on by the Trump administration, pointed to an array of promising NIH activities, including the development of new technologies to provide insights into human brain circuitry and function through the Brain Research through Advancing Innovative Neuroethologies (BRAIN initiative) and the use of the gene - editing tool CRISPR - Cas9 to correct mutations and clear the way to develop and test a «curative therapy» for the first molecular disease: sickle cell disease.

«Our research has identified a gene affecting another type of ischemic stroke, due to small vessel disease, and also suggests some genes may be associated with both ischemic and hemorrhagic stroke and may act through a novel pathway affecting pericytes, a type of cell in the wall of small arteries and capillaries.

This animation guides us through the immune pathways involved in the disease, from the first signs of self - reactive immune cells to joint damage and other symptoms.This article was reproduced with permission and was first published on January 25, 2016.

Researchers have developed a new approach for growing and studying cells they hope one day will lead to curing lung diseases such as cystic fibrosis through «personalized medicine.»

However, when mature blood cells are lost, for example through severe bleeding or during infections, HSCs become activated to generate new «progenitor» cells — the cells that replenish the blood supply and produce immune cells to fight disease.

Recent advances in our understanding of cancer have revealed that the disease can not be understood through simple analysis of genetic mutations within the cancerous cells.

Recent advances in our understanding of cancer have revealed that the disease can not be understood through simple analysis of genetic mutations within cancerous cells.

In additional experiments, the NYU team showed that the TB - transporting dendritic cells had to first pass through the lungs — as would be expected in the natural course of the disease that is passed by someone breathing in infected droplets — before heading to the lymph nodes to elicit a strong immune response.

For example, the camera could be used to visualize energy metabolism as it occurs within a cell's mitochondria or the way light passes through tissue, an important consideration for therapies that use lasers to destroy diseased tissue with the goal of leaving healthy tissue unharmed.

Through a few clever molecular hacks, researchers at Columbia University Medical Center have converted a natural bacterial immune system into a microscopic data recorder, laying the groundwork for a new class of technologies that use bacterial cells for everything from disease diagnosis to environmental monitoring.

It's not all just fun and games: Understanding how cells — especially white blood cells — navigate through the human body could help scientists create better treatments for cancer, infectious disease, and autoimmune disorders.

They found that these diseased cells could take up the nanocrystals, whereas healthy cells do not; they preferentially «stain» the cancer cells, which can clearly be seen under the microscope through their bright luminescence.

Here, we show that in the antibody - mediated autoimmune disease pemphigus vulgaris (PV), autoantigen - based chimeric immunoreceptors can direct T cells to kill autoreactive B lymphocytes through the specificity of the B cell receptor (BCR).

In a series of studies this year, molecular geneticists at the University of Pittsburgh School of Medicine used a harmless virus to ferry new genes through the bloodstream, across blood vessel walls, and into almost every muscle cell in the bodies of hamsters bred to have human genetic diseases.

Through studies conducted in mice, Oliver M. Steinmetz, MD (University Hospital Hamburg Eppendorf, in Germany) and his colleagues have shown that the messenger protein IL - 6, which is rapidly produced at high levels during an acute inflammatory form of kidney disease, potently dampens activation of tissue - destructive immune cells called macrophages.

By identifying these cells, which have gained the ability to move through the body, we have found a potential new way to monitor the disease.

A robot made from a single strand of DNA could one day ferry medicines to diseased cells through the bloodstream or build chemical compounds in molecular factories.

Their findings — that nanotubes and vesicles are an important part of the communications process — show that the extracellular vesicles contribute to the complexity of African trypanosomiasis through the transfer of virulence factors between parasites and inadvertent interaction with host cells, which has a profound effect on disease, the study notes.

PHILADELPHIA --(July 11, 2017)-- Researchers at The Wistar Institute, an international leader in biomedical research in the fields of cancer, immunology and infectious diseases, with collaborators at Indiana University Melvin and Bren Simon Cancer Center and Syndax Pharmaceuticals, Inc., (Nasdaq: SNDX) announce the results of a preclinical study demonstrating that entinostat, Syndax's oral, Class - I histone deacetylase inhibitor, enhances the antitumor effect of PD - 1 (programmed death receptor - 1) blockade through the inhibition of myeloid derived suppressor cells (MDSCs).

In a study published in the journal Proceedings of the National Academy of Sciences, Shinya Yamanaka, MD, PhD, who first created induced pluripotent stem cells (iPSCs), and his colleagues at the Gladstone Institutes found a way to increase the efficiency of stem cell reprogramming through research on a rare genetic disease.

Indeed, human pluripotent stem cell lines and derivatives, which express a disease - related mutated gene, represent a relevant and pertinent disease cell model to analyse pathological mechanisms through large - scale drug screenings.

Through the use of stem cell - based organoids researchers are making big strides in the study of neurodevelopmental diseases such as schizophrenia and autism.

«The support provided by this grant will allow UCSD to enhance our collaborative stem cell program so that we may accelerate our goals of improving health and conquering disease through regenerative medicine,» said Marye Anne Fox, UCSD Chancellor.

For the first time, through the use of human embryonic stem cells (hES) sourced from pre-implantation diagnosis, researchers from Inserm's Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (I - Stem) have successfully identified the previously unknown mechanisms involved in Steinert» disease, also known as type 1 myotonic dystrophy.

Jason Lee / Reuters In the next few months, surgeons in the Chinese city of Zhengzhou will carefully drill through the skulls of people with Parkinson's disease and inject 4 million immature neurons derived from human embryonic stem cells into their brains.

This makes a strong case for the utility of lineage through program cells for diseased modeling.

July 21, 2016 Antibiotic treatment weakens progression of Alzheimer's disease through changes in the gut microbiome Long - term treatment with broad spectrum antibiotics decreased levels of amyloid plaques, a hallmark of Alzheimer's disease, and activated inflammatory microglial cells in the brains of mice in a new study by neuroscientists from the University of Chicago.

Anna Huttenlocher, University of Wisconsin, USA Neutrophils in the Tumor Microenvironment Neutrophils, Wounds, and Cancer Progression Stefan Kaufmann, Max Planck Institute, Germany Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells Kathryn Moore, New York University, USA MicroRNA -33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis Lalita Ramakrishnan, University of Cambridge, UK Myeloid Growth Factors Promote Resistance to Mycobacterial Infection by Curtailing Granuloma Necrosis through Macrophage Replenishment Beth Stevens, Harvard University, USA Microglia: Dynamic Mediators of Synapse Development and Plasticity Do glia drive synaptic and cognitive impairment in disease?

Basically what was happening when you use a hematopoietic stem cell to correct an inherited metabolic disease is that through engraftment of that cell you are allowing that cell to become the replacement source for the missing enzyme or other factor - almost like a cellular form of gene therapy or, as I call it, «poor man's gene therapy».

The onset and progression of disease in inherited ALS is determined by the motor neurons and microglia, small immune cells in the spinal cord, which migrate through nerve tissue and remove damaged cells and debris.

Through the activities of the Cell Circuits Program and the Klarman Cell Observatory, Broad researchers are working to systematically define the genetic and molecular circuits in a wide range of cell types, tissues, and diseaCell Circuits Program and the Klarman Cell Observatory, Broad researchers are working to systematically define the genetic and molecular circuits in a wide range of cell types, tissues, and diseaCell Observatory, Broad researchers are working to systematically define the genetic and molecular circuits in a wide range of cell types, tissues, and diseacell types, tissues, and diseases.

San Diego, California, October 29, 2013 — ViaCyte, Inc., a leading regenerative medicine company focused on developing new approaches to treat major diseases through the application of a stem cell - derived cell therapy, announced today that the Company was granted over 20 patents worldwide in 2013 thus far, three U.S. and twenty foreign.

She is registred to the National Order of Biologists in the province of Palermo; collaboration in research project from 2012 to 2015 at the Department of Biopathology and Biotechnology, University of Palermo, focusing the study on the identification of molecules capable to modulate intracellular metabolic pathways for the prevention and treatment of infectious, tumor and degenerative disease, in collaboration with Prof. Angela Santoni, University of Rome; collaboration in research project in 2011 at the hospital «Villa Sofia Cervello» of Palermo to study methods can cure the genetic defect that causes thalassemia through genetic engineering; she studies different mechanisms of the differentiation and the activation of human gammadelta T cells as effector cells of the immune response against cancer and infectious diseases; she investigates about the identification and development of biomarkers of resistance and susceptibility to Mycobacterium tuberculosis infection; Valentina Orlando has published 13 papers in peer reviewed journals and 3 comunications at national and international congress.

In the fall of 2012, their group demonstrated that misfolded versions of α - synuclein, the protein implicated in Parkinson's disease, can be transmitted from cell to cell in mouse models, adding weight to a hypothesis that a common mechanism of neurodegenerative disorders could involve the passage of misfolded proteins through the central nervous system.

Tenaya is dedicated to addressing heart failure through a multipronged effort that targets the fundamental cellular pathologies present in diseased cardiac muscle and leverages cutting - edge research in cardiac regeneration, induced pluripotent stem cells, and CRISPR technologies.

Stem cells actively bring diseased neurons back from the brink via cross-talk through gap junctions, the connections between cells that allow molecular signals to pass back and forth.

That deeper knowledge, that you can only get through a genomic analysis of the cells, will help us develop better ways of using these cells to come up with new treatments for deadly diseases.»

The HDCA programme will create genomic reference maps of all the cells that are important for human development, which will revolutionise our understanding of health and disease, from miscarriages and children's developmental disorders, through to cancer and ageing.

Most iPS cells have been derived through the use of viral vectors and are not ideal for the study and potential treatment of human diseases.