Sentences with phrase «cell disease who»

The study represents an important step toward more effectively treating certain patients with sickle cell disease who need frequent blood transfusions and currently have few options.

A new study in the Journal of Clinical Sleep Medicine revealed that 44 percent of adults with sickle cell disease who report trouble sleeping actually have a clinical diagnosis of sleep disordered breathing, including sleep apnea, which lowers their oxygen levels at night.

Not exact matches

Unbeknownst to Jones, however, the parents are actually trying to save their son, who has a neurodegenerative disease which is causing his brain cells to decay.

Is the right kind of Christian the one who wants to end stem cell research that has the potential to unlock cures for devastating diseases, like GW Bush did and Mitt Romney will surely do?

He was featured last April in a segment that included Michael J. Fox - who suffers from Parkinson's disease and is an avid supporter of foetal stem - cell research through his charitable foundation.

Non-alcoholic fatty liver disease (NAFLD) is defined medically as macrovesicular steatosis, or abnormal retention of lipids (fats) sufficient and large enough to distort or replace the nuclei of liver cells among those who consume less than 20 grams -LRB-.7 ounces) of alcohol per day.

Individuals who carry sickle cell trait (the unexpressed mutation of sickle cell anemia) are more likely to survive malaria and therefore, the trait is actually protective against a disease that is endemic in many parts of the world.

Yes the home group will contain some higher risk moms (some VBAC, some breech, some GDM) but it won't contain the full spectrum of high risk that the hospital gets: Women with clotting disorders on heparin, maternal heart disease, moms addicted to crack, moms with HIV, 12 and 13 year olds, women who walk in off the streets in labor with no prenatal care, women with sickle cell and cystic fibrosis and type 1 diabetes, babies with severe anomalies.

(Some experts point out that a sick baby who receives his or her own stem cells during a transplant could very well just develop the disease all over again.)

These unformed stem cells have the ability to turn into mature blood cells — and could save the life of someone who needs a bone marrow transplant, and possibly other diseases, since stem - cell research remains in its infancy, really.

Interestingly, those who suffer from narcolepsy, a disease in which people are excessively tired and may spontaneously fall asleep during the day, also lack orexin due to a breakdown in the brain cells that produce it.

Breastfeeding is contraindicated in infants with classic galactosemia (galactose 1 - phosphate uridyltransferase deficiency) 103; mothers who have active untreated tuberculosis disease or are human T - cell lymphotropic virus type I — or II — positive104, 105; mothers who are receiving diagnostic or therapeutic radioactive isotopes or have had exposure to radioactive materials (for as long as there is radioactivity in the milk) 106 — 108; mothers who are receiving antimetabolites or chemotherapeutic agents or a small number of other medications until they clear the milk109, 110; mothers who are using drugs of abuse («street drugs»); and mothers who have herpes simplex lesions on a breast (infant may feed from other breast if clear of lesions).

Screening for sickle cell disease also finds babies who are carriers of this or other red blood cell diseases.

Pregnant women, mothers who have recently given birth, and people with sickle cell disease also require increased folate.

It's necessary, they argue, to protect the babies who would otherwise be born with mutated mitochondria - the power - producing bits of cells - which can lead to serious diseases that currently affect around one in every 6,500 children.

Cadwell cautions that such a strategy must await further evidence to confirm his theory that this trend in Paneth cell death occurs in people deficient in ATG16L1 who are, like his study mice, prone to higher risk of inflammatory disease and transplant rejection.

«If we want to treat the greatest number of diseases, we need to figure out how to get these molecules inside the cells of patients — not just increasing the number of target cells but also hitting tissues other than the liver,» says Anderson, who co-founded a company called CRISPR Therapeutics to pursue those goals.

What impact they may have had is now only a guess, but this study revealed that these cells were less common in the brains of women who had Alzheimer's disease, suggesting they may be related to the health of the brain.

The idea to specifically study this group of patients was based on groundbreaking research Garon published in the New England Journal of Medicine last year, which found that among patients who received pembrolizumab, those with PD - L1 expression on at least 50 percent of their cancer cells showed the longest survival and disease control.

The trial enrolled 361 patients with recurrent or metastatic head and neck squamous cell carcinoma who had not responded to platinum - based chemotherapy, a rapidly progressing form of the disease with an especially poor prognosis, said Dr. Ferris.

Migueles has found that for those who control the virus their CD8 T cells of are both quantitatively and qualitatively different from those who follow the typical course of disease progression.

Scientists from the University of Cambridge's Institute for Medical Research obtained skin cells from 10 patients — seven who had various forms of inherited liver disease, and three healthy controls.

Eighteen adults with severe eye disease who were among the first people to receive transplants created from human embryonic stem cells (hESCs) continue to have no apparent complications with the introduced cells after an average of nearly 2 years, according to the latest status report on their health.

«Due to the inhibitory function of Treg cells, people have been trying to use these cells for therapy in human autoimmune diseases or transplantation,» explains professor Yun Cai Liu, Ph.D., who led the current study.

«The study of this type of tumours has been problematic up to now due to the lack of cell models and the appropriate animal models,» says CNIC researcher Juan Carlos Ramírez, who adds that the difficulty of generating these chromosomal translocations had limited the availability of cells with this mark of the disease.

Dr Lee Campbell, Research Projects and Science Communications Manager at Cancer Research Wales, who part - fund the study, commented: «This is an exciting breakthrough as cancer stem cells are thought to be responsible for the failure of many cancer treatments and the re-emergence of cancers, often many years after the initial disease.

They tested neural tissue from people who had died from Huntington's disease, a degenerative disorder of nerve cells in the base of the brain.

For his part, Collins, who has led NIH since 2009 and been kept on by the Trump administration, pointed to an array of promising NIH activities, including the development of new technologies to provide insights into human brain circuitry and function through the Brain Research through Advancing Innovative Neuroethologies (BRAIN initiative) and the use of the gene - editing tool CRISPR - Cas9 to correct mutations and clear the way to develop and test a «curative therapy» for the first molecular disease: sickle cell disease.

Brains of people who died from various diseases caused by tangled tau had more dead and damaged cells if the people carried APOE4.

New technology that transforms a cell phone into a powerful, mobile microscope could significantly improve malaria diagnoses and treatment in developing countries that often lack the resources to address the life - threatening disease, says a Texas A&M University biomedical engineer who has created the tool.

In the new work, neurologist Teresa Coelho of the Hospital de Santo Antonio in Portugal and colleagues tested RNAi in patients who had transthyretin amyloidosis, a fatal genetic disease in which liver cells pump out excess amounts of a protein called transthyretin.

The former target, say, using gene editing techniques to inactivate HIV receptors and achieve resistance of blood cells to the virus (which Sangamo BioSciences is working on in clincial trials) is different than helping parents who both carry genes for Huntington's Disease to have a child that is free of the disease (a change to the genome that would be passed on to future generations and would likely not be very commonly nDisease to have a child that is free of the disease (a change to the genome that would be passed on to future generations and would likely not be very commonly ndisease (a change to the genome that would be passed on to future generations and would likely not be very commonly needed).

That message, delivered in two studies published today, is both good news and bad news for researchers who hope to use so - called induced pluripotent stem cells (iPS cells) to study diseases and perhaps some day treat patients.

«In these diseases of mitochondrial dysfunction, in a sense, it's a false starvation situation for the cell — there are plenty of nutrients, but because there's a block in the mitochondria's normal function, the mitochondria behave as if there's not enough oxygen,» says Chen, who with Birsoy, authored a paper in the journal Cell Reports describing this wcell — there are plenty of nutrients, but because there's a block in the mitochondria's normal function, the mitochondria behave as if there's not enough oxygen,» says Chen, who with Birsoy, authored a paper in the journal Cell Reports describing this wCell Reports describing this work.

«Our findings could have a significant impact on the treatment of autoimmune diseases, as well as on stem cell and immuno - oncology therapies,» said Gladstone Senior Investigator Sheng Ding, PhD, who is also a professor of pharmaceutical chemistry at the University of California, San Francisco.

And it suggests that stem cells derived from embryos should remain the primary reference for iPS cells when researchers want to compare how cells from diseased patients behave, says Nissim Benvenisty of Hebrew University of Jerusalem, who has studied differences between ES cells and iPS cells derived from carriers of fragile X syndrome.

Combining radiation therapy with chemotherapy for patients with limited metastatic non-small cell lung cancer (NSCLC) may curb disease progression dramatically when compared to NSCLC patients who only receive chemotherapy, according to a new randomized phase II clinical trial reported today at the 59th Annual Meeting of the American Society for Radiation Oncology (ASTRO).

«This provides strong evidence that Müller glia are important therapeutic targets for treating degenerative eye diseases,» said Sehwon Koh, Ph.D., who is the lead author of this paper and a postdoctoral fellow in the laboratory of Cagla Eroglu, Ph.D., an associate professor of cell biology and neurobiology at the Duke University Medical Center.

Current chemotherapy treatments cure the disease in fewer than 10 % of patients who have a FLT3 mutation — partly because toxic chemotherapy drugs can be used for only a few days at a time, not killing as many cancer cells as they might.

The new management guidelines consist of more than 500 specific directions for physicians who are caring for patients with sickle cell disease.

Currently, there are not enough physicians who specialize in the care of adults with sickle cell disease, which means that many are seen by primary care physicians or other specialists,» said Ms. Miller.

«By learning more about how these cells work, we are one step closer to understanding the disease states in which these cells should be studied,» said Cagla Eroglu, an assistant professor of cell biology and neurobiology at the Duke University Medical Center, who led the research.

«This is such a prevalent virus... about 25 percent of stem cell transplant patients get infected [with rhinovirus] during the first year,» said Boeckh, who heads Fred Hutch's Infectious Disease Sciences Program.

«These national guidelines are directed not just to hematologists but to all medical practitioners who might encounter sickle cell disease patients, to inform them about hydroxyurea and how to best offer general medical care to them,» Dr. Buchanan said.

One clinician who has not waited for controlled clinical studies is California osteopath David Steenblock, who offers stem cell therapy for more than 20 diseases, including Alzheimer's, traumatic brain injury, Parkinson's, arthritis, stroke, and heart disease.

Paizley, the teenager who was once nearly destroyed by sickle - cell disease, is now free of the illness that haunted her, free to attend school like all of her healthy friends.

British newspapers reported this weekend that Ian Wilmut, the University of Edinburgh biologist who led the team that in 1997 cloned Dolly the sheep, is getting out of the cloning business in light of the new findings, which seem to offer researchers a likely new source of stem cell lines for basic research that could one day lead to new treatments and perhaps cures for spinal injuries, diabetes and debilitating disorders such as multiple sclerosis and Parkinson's disease.

«Endothelial cells play a very important role in multiple steps of many diseases, from initiation to the onset of clinical complications,» says Aikawa, who was not part of the research team.

The team is now working with doctors at Massachusetts General Hospital, who hope to use the new, noninvasive technique to study cells involved in cancer, asthma, and other conditions in which cell properties change as a disease progresses.

«Preventing graft - versus - host disease and relapse after transplant requires a difficult balance of eliminating the bad, overactive effector T cells, without suppressing the good, regulatory T cells,» said Kean, who is also an associate professor of pediatrics at the University of Washington School of Medicine and a member of the Fred Hutchinson Cancer Research Center.