Not exact matches
People with the
disorder seem to have more active immune
cells inside their brains, and now this activity has been spotted even
before the
disorder develops.
«Now that we know a fetus can become tolerant to a foreign stem
cell source, we can really think big and consider looking at how other types of stem
cells might be used to treat everything from neurological
disorders to muscular
disorders before birth,» MacKenzie added.
• Patients must have adequate coagulation (international normalized ratio (INR) or prothrombin time (PT), partial thromboplastin time (PTT) ≤ 1.5 times ULN) • Adequate liver function (total bilirubin ≤ 1.5 times the ULN, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 times ULN Exclusion Criteria: • Presence of active / uncontrolled central nervous system involvement • History of clinically significant cardiac disease; uncontrolled hypertension • Left ventricular ejection fraction (LVEF) < 45 % • Allogeneic stem
cell transplant within 100 days
before first dose of study drug • Known history of human immunodeficiency virus (HIV) infection • Chronic or active hepatitis B or C, requiring antiviral therapy • Evidence of history of bleeding
disorder, dialysis, or coexisting cancer that is distinct in primary site or histology from the cancer evaluated in this study • Serious, uncontrolled infection • Unresolved chronic toxicity > grade 1 from prior therapy • Use of strong CYP3A4 inhibitors or strong inducers within 7 days prior to the start of study treatment and for the duration of the study
SAN FRANCISCO, CA — Researchers at the Gladstone Institutes and University of California, San Francisco have shown that a loss of
cells in the retina is one of the earliest signs of frontotemporal dementia (FTD) in people with a genetic risk for the
disorder — even
before any changes appear in their behavior.