Sentences with phrase «cell dysfunction caused»

The beta cell dysfunction caused the high blood sugars, not the other way around.

Not exact matches

«We now have a handle on the detailed structure of a complex web of interactions that causes global dysfunction in cells resulting in degeneration of the brain.»

Death and dysfunction of these cells cause vision loss in conditions like glaucoma and multiple sclerosis.

In EAE, as with MS, immune cells attack a nerve cell protein called myelin, causing symptoms ranging from impaired vision to severe motor dysfunction and even death.

Kozai explains, «Dysfunction in glial cells has been implicated as a cause and / or major contributor to an increasing number of neurological and developmental diseases.

The researchers developed two such signatures from cells found in the urine that could differentiate, in a two - step approach, the common causes of acute kidney dysfunction with high accuracy.

Vacuolating cytotoxin A (VacA) was previously the only main H. pylori factor known to act on mitochondria, causing cellular membrane and organelle dysfunction and leading to cell death.

We also demonstrate that NS1 from DENV1, DENV2, DENV3, and DENV4 triggers endothelial barrier dysfunction, causing increased permeability of human endothelial cell monolayers in vitro.

The study is published in the scientific journal Oncoimmunology and describes how a cell type in the blood, the neutrophil, causes kidney dysfunction in mice with cancer.

Understanding the functions of lipids and cell membranes is key to progress in basic cell and tissue biology as well as in the many diseases that are caused by lipid dysfunction.

Because they have the capacity to detect issues in the body which are causing pain or dysfunction, stem cells are able to respond and provide the correct «tools» needed for healing.

A failure of normal astrocyte generation by CNS precursor cells has been discovered to be a consequence of the mutations that cause Vanishing White Matter leukodystrophy [7], and dysfunction of astrocytes has also been suggested to be of importance in models of amyotrophic lateral sclerosis [8], forebrain ischemic injury [9], epileptic seizures [10], Huntington's disease [11], tuberous sclerosis [12] and Rett syndrome [13].

The loss of contractile cells and the inability of the adult mammalian heart to regenerate is a major cause of cardiac dysfunction and heart failure.

Because these cells have the capacity to detect changes in the body which are causing pain or dysfunction, they respond and communicate with the body's needs to provide the correct tools needed for healing.

«Mutations in the Intellectual Disability Gene Ube2a Cause Neuronal Dysfunction and Impair Parkin - Dependent Mitophagy», Haddad et al., Molecular Cell, 2013.

The main cause of this beta cell dysfunction is the accumulation of fat inside your muscle and liver (2 — 7).

Saturated fat causes more of those toxic breakdown products and mitochondrial dysfunction, and increases oxidative stress, free radicals, and inflammation, establishing a vicious cycle of events in which saturated fat - induced free radicals cause dysfunction in the little power plants within our muscle cells, which causes an increase in free radical production and the impairment of insulin signaling.

For example, Dr. Greger discusses a» vicious cycle of events in which saturated fat induced free radicals causes dysfunction in the little powerplants within our muscle cells, which causes an increase in free production and impairment of insulin signaling.»

When this pathway breaks down it causes increased levels of oxidative stress within the cell that leads to the glutathione depletion and mitochondrial dysfunction (17).

What causes the beta cell dysfunction in the first place?

Eventually the excess fat spills over to the pancreas, leading to beta cell dysfunction, reaching a trigger level, and causing clinical Type 2 diabetes.

Their metabolites accumulate in muscle and fat cells, activate proinflammatory signalling cascades, cause mitochondrial dysfunction, and interfere with insulin - stimulated glucose transport.

As your mitochondria start to dysfunction, your cells become starved for energy and damaged, causing them to function less efficiently allowing your metabolism to get sluggish causing you to gain weight.

Antioxidants work by significantly slowing or preventing the oxidative — or damage from oxygen — process caused by substances called free radicals that can lead to cell dysfunction and the onset of problems like heart disease and diabetes.

Folate was also very recently shown to increase the growth of stem cells, which is important because stem cell pools deplete with age and are a major cause of organ aging and dysfunction.

Antioxidants work by significantly slowing or preventing the oxidative — or damage from oxygen — process caused by substances called free radicals that can lead to cell dysfunction and the onset of problems like heart disease and diabetes, but also of the inflammation underpinning psoriasis.

Dr. Warburg showed that cancer cells, even in the presence of oxygen, preferentially ferment sugar for energy, and believed this metabolic dysfunction to be the primary cause of cancer, not just a symptom.

Avigen discovered the utility of AV411 through its internal program to develop innovative and targeted approaches to reducing nervous system dysfunction caused by glial cell activation.

Naphthalene may cause not only GI upset, but also severe neurological dysfunction (including seizure activity) and red blood cell damage: methemoglobinemia in which red blood cells can not deliver oxygen properly to the body's cells.

Used in conjunction with milk - thistle, a nutraceutical supplement, these compounds are shown to decrease cell damage caused by biliary dysfunction and help the liver rebuild healthy functional tissue.

Seborrhea can be a primary condition in rare cases, meaning it is caused by a dysfunction in your dog's skin cells.

Mild traumatic brain injury may cause temporary dysfunction of brain cells.