Sentences with phrase «cell dysfunction in»

What causes the beta cell dysfunction in the first place?

His plans for research in his own lab involve «continuing to look at the mechanisms of T cell dysfunction in human and mice.

Research Interests: Tumor immunity, T lymphocyte effectors, immunotherapy, T - cell dysfunction in cancer, myeloid derived suppressor cells (MDSC) and angiogenesis

This suggests to us that B cell dysfunction in early development may contribute to later mental disorders, a possibility that we believe deserves further exploration in future studies.»

The latter substance, phosphorylated tau, is responsible for neurofibrillary tangles, which are suspected of contributing to the nerve cell dysfunction in the brain that is responsible for Alzheimer's memory symptoms.

Not exact matches

In contrast, SOM cells are involved in cognition and emotion, and dysfunctions in these cells may contribute to ADHD and schizophrenia.&raquIn contrast, SOM cells are involved in cognition and emotion, and dysfunctions in these cells may contribute to ADHD and schizophrenia.&raquin cognition and emotion, and dysfunctions in these cells may contribute to ADHD and schizophrenia.&raquin these cells may contribute to ADHD and schizophrenia.»

In cell culture, low concentrations of these corrector molecules can reduce mitochondrial impairment and neuronal dysfunction.

But signs of age - associated dysfunction in the cell diminish.

It is these people who develop diabetes, either type 1 or type 2, while others with tougher beta cells will remain healthy even in if they suffer from autoimmunity or metabolic dysfunction of the liver.»

The researchers used several measures to determine whether the stem cells were effective in alleviating neuropathic pain and bladder dysfunction at six months.

«We now have a handle on the detailed structure of a complex web of interactions that causes global dysfunction in cells resulting in degeneration of the brain.»

The protein's role in the pathway leading to memory impairment, however, remained unclear until scientists from IMCB utilised live - cell imaging techniques to elucidate the mechanism of memory impairment and illustrated how SNX27 attributes to synaptic dysfunction.

Dysfunction of these cells, as may occur in disease, is linked to neurodevelopmental disorders and neurodegenerative conditions.

Physician David Nathan, director of the diabetes center at Massachusetts General Hospital in Boston, notes in an email message that «what is ironic here is that [free radicals are] generally thought to be bad in human diabetes,» because they lead to dysfunction in the cells that make insulin and vascular complications.

In March 2016, Penn researchers published a study in Blood that showed long - term ibrutinib treatment reverses the dysfunction of T cells in CLL and that combining CAR therapy with ibrutinib enhanced engineered T cell proliferation in micIn March 2016, Penn researchers published a study in Blood that showed long - term ibrutinib treatment reverses the dysfunction of T cells in CLL and that combining CAR therapy with ibrutinib enhanced engineered T cell proliferation in micin Blood that showed long - term ibrutinib treatment reverses the dysfunction of T cells in CLL and that combining CAR therapy with ibrutinib enhanced engineered T cell proliferation in micin CLL and that combining CAR therapy with ibrutinib enhanced engineered T cell proliferation in micin mice.

Death and dysfunction of these cells cause vision loss in conditions like glaucoma and multiple sclerosis.

«In these diseases of mitochondrial dysfunction, in a sense, it's a false starvation situation for the cell — there are plenty of nutrients, but because there's a block in the mitochondria's normal function, the mitochondria behave as if there's not enough oxygen,» says Chen, who with Birsoy, authored a paper in the journal Cell Reports describing this worIn these diseases of mitochondrial dysfunction, in a sense, it's a false starvation situation for the cell — there are plenty of nutrients, but because there's a block in the mitochondria's normal function, the mitochondria behave as if there's not enough oxygen,» says Chen, who with Birsoy, authored a paper in the journal Cell Reports describing this worin a sense, it's a false starvation situation for the cell — there are plenty of nutrients, but because there's a block in the mitochondria's normal function, the mitochondria behave as if there's not enough oxygen,» says Chen, who with Birsoy, authored a paper in the journal Cell Reports describing this wcell — there are plenty of nutrients, but because there's a block in the mitochondria's normal function, the mitochondria behave as if there's not enough oxygen,» says Chen, who with Birsoy, authored a paper in the journal Cell Reports describing this worin the mitochondria's normal function, the mitochondria behave as if there's not enough oxygen,» says Chen, who with Birsoy, authored a paper in the journal Cell Reports describing this worin the journal Cell Reports describing this wCell Reports describing this work.

To find genetic mutations that would rescue the cells, Chen and Birsoy mimicked mitochondrial dysfunction in a haploid genetic system developed by former Whitehead Fellow Thijn Brummelkamp.

«In the study we challenged the view that the age - dependent impairment in glucose homeostasis is solely due to intrinsic, dysfunction of islet cells, and hypothesized that it is instead affected by systemic aging factors,» says first author Joana Almaca at the Diabetes Research Institute, University of MiamIn the study we challenged the view that the age - dependent impairment in glucose homeostasis is solely due to intrinsic, dysfunction of islet cells, and hypothesized that it is instead affected by systemic aging factors,» says first author Joana Almaca at the Diabetes Research Institute, University of Miamin glucose homeostasis is solely due to intrinsic, dysfunction of islet cells, and hypothesized that it is instead affected by systemic aging factors,» says first author Joana Almaca at the Diabetes Research Institute, University of Miami.

They showed that stress in pancreatic cells due to sleep deprivation may contribute to the loss or dysfunction of these cells important to maintaining proper blood sugar levels, and that these functions may be exacerbated by normal aging.

One reason group A Streptococcus and other invasive pathogens are so dangerous is they release pore - forming toxins that can poke holes in the membranes of cells within a person's body, leading to cellular dysfunction or cell death.

While changes in insulin secretion are unlikely to play a major role in the acute effects of SD, cellular stress in pancreatic tissue suggests that chronic SD may contribute to the loss or dysfunction of endocrine cells, and that these effects may be exacerbated by normal aging, say the researchers.

In EAE, as with MS, immune cells attack a nerve cell protein called myelin, causing symptoms ranging from impaired vision to severe motor dysfunction and even death.

This would alter ion levels inside the cells and in turn trigger neuronal dysfunction and cell death.

Kozai explains, «Dysfunction in glial cells has been implicated as a cause and / or major contributor to an increasing number of neurological and developmental diseases.

The researchers developed two such signatures from cells found in the urine that could differentiate, in a two - step approach, the common causes of acute kidney dysfunction with high accuracy.

Published in Nature Neuroscience, the findings suggest that astrocytes — star - shaped cells that are abundant in the brain and support neuronal function — are important regulators of information storage, and their dysfunction might lead to memory decline in disease.

For example, how genetic programs affect the function of specific cell types, how they vary early or later in life and how dysfunction in these programs might contribute to disease, all of which could help scientists learn more about the fundamental workings of the brain.

Damage to astrocytes — star - shaped cells found in the brain and spinal cord — is found in many neurodegenerative conditions, but it's been unclear exactly what role astrocyte dysfunction plays in the development of disease.

«Our findings define a potential mechanism for neuronal cell death in Alexander disease and possibly other neurodegenerative diseases with astrocyte dysfunction.»

«Each cell in the kidney seems to have a unique non-redundant function, and dysfunction of specific cell types present with specific symptoms in people.

The researchers discovered that genetic dysfunction in what they call the HIPPO - TAZ / YAP and Gαs - protein feedback circuit disrupts the balanced production of Schwann cells.

But there is no doubt that stem cell therapy will become an important tool in the treatment of erectile dysfunction.»

Previous studies suggest that the symptoms of GWI are due to dysfunction of the mitochondria, the site in cells where molecules that power the body's processes are produced.

We also demonstrate that NS1 from DENV1, DENV2, DENV3, and DENV4 triggers endothelial barrier dysfunction, causing increased permeability of human endothelial cell monolayers in vitro.

«Stem cells shown to restore erection capability in men with erectile dysfunction.»

The study is published in the scientific journal Oncoimmunology and describes how a cell type in the blood, the neutrophil, causes kidney dysfunction in mice with cancer.

These cells were remarkable on their own as they were able to effectively reverse the scarring that contributes to lung dysfunction and difficulty in breathing,» he said.

Cholesterol in β - cell dysfunction: The emerging connection between HDL cholesterol and type 2 diabetes

Longitudinal studies in animals that spontaneously develop T2D (nonhuman primates and domestic cats) showed that detection of IAPP aggregates precedes β cell dysfunction and clinical signs of the disease (Howard, 1986; de Koning et al., 1993; Ma et al., 1998).

However, compelling evidence suggests that accumulation of amyloid aggregates in the islets of Langerhans might significantly contribute to β cell dysfunction and disease (Hull et al., 2004; Haataja et al., 2008; Jurgens et al., 2011; Mukherjee et al., 2015).

«It was known that acute exposure to pyrethroids could lead to immune dysfunction, and that the molecules they act on can be found in immune cells; now we need to know more about how longer - term exposure affects the immune system in a way that increases risk for Parkinson's.»

The overall goal of this research is to provide new insight into the function and dysfunction of human neural cell populations in aging and neurological disorders, such as LOAD, and to identify mechanisms and molecules that can be translated to developing and testing novel diagnostic tools and therapeutics.

Aguirre, J.A.; Kehr, J.; Yoshitake, T.; Liu, F.L.; Rivera, A.; Fernandez - Espinola, S.; Andbjer, B.; Leo, G.; Medhurst, A.D.; Agnati, L.F.; Fuxe, K. Protection but maintained dysfunction of nigral dopaminergic nerve cell bodies and striatal dopaminergic terminals in MPTP - lesioned mice after acute treatment with the mGluR5 antagonist MPEP.

Dysfunction of mitochondria, the energy - generating organelle in human cells, is one hypothesis concerning the severe fatigue experienced by ME / CFS patients.

The structural analysis guides further mutagenesis and biochemical experiments in both reconstituted systems in vitro and in primary cells, to finely analyze the mechanisms that mediate macromolecular function, or lead to a pathological dysfunction.

We are currently profiling inhibitory interneuron cell types in mouse models of AD to identify potential molecular mechanisms of interneuron dysfunction and potential targets of intervention.

Human iPS cell - derived hepatocytes differentiated with our robust differentiation protocol and cultured using our novel maintenance medium provide an inexhaustible, consistent supply of functional hepatocytes that can be used to advance the understanding of diseases related to dysfunction in liver metabolism, including NAFLD / NASH, type 2 diabetes, and metabolic syndrome.

Aging research reveals that some aging phenotypes are reversible, in fact age related dysfunctions may be classified in an early reversible stage, and in a later stage with permanent damage (DNA mutations or deletions or cell death) 1.

Nicola Watt (Reichmann, TUD)-- «Mitochondrial dysfunction and lipid metabolism in cell culture models of respiratory chain and neurodegenerative diseases» (2007)