Analysis for embryos was done on images of seven different embryos (seven mutant and seven wild type embryos) inside gravid hermaphrodites (only one and two
cell early embryonic stages were chosen for comparison).
Not exact matches
«Indeed, when we studied the mice at the
embryonic stage, we saw the
cells between the muscle fibers expanded explosively and formed tumors
early in development,» Hatley said.
Changes in cellular metabolites have been shown to regulate
embryonic stem
cell development at the
earliest stages of life.
«Changes in metabolites can regulate
earliest stages of development: Findings may offer insights into a variety of disorders, advance
embryonic stem
cell research.»
This discovery by the scientists at the CRG provides an insight into stem
cell - forming molecular mechanisms, and is therefore of great interest for studies on the
early stages of life, during
embryonic development.
Salk scientists and colleagues have proposed new molecular criteria for judging just how close any line of laboratory - generated stem
cells comes to mimicking
embryonic cells seen in the very
earliest stages of human development, known as naïve stem
cells.
After two
earlier published attempts that led to
early -
stage embryos but not confirmed
embryonic stem
cells, Mitalipov and colleagues took steps to preserve a protein complex believed to help primate eggs restructure transplanted DNA, and employed a new imaging system to observe the egg's chromosomes directly instead of by staining them or using ultraviolet light, which might damage DNA.
The ability of a fertilized egg to generate both
embryonic and extra-
embryonic tissues is referred to as «totipotency,» an ultimate stem
cell state seen only during the
earliest stages of
embryonic development.
A second method involves introducing the transgenic DNA into
embryonic stem
cells (ES
cells) derived from a mouse embryo at the very
early stages of development.
The gene, known as gata5, acts in
embryonic cells, which are primordial, unspecialized
cells that form in the
earliest stage of
embryonic development and are genetically programmed to evolve into one of many specialized
cell types, such as skeletal muscle
cells, nerve
cells, blood
cells, skin
cells, and liver
cells.
Professor Martinez - Arias and colleagues, supported by the European Research Council and the Wellcome Trust, have reconstructed these
early stages of development using mouse
embryonic stem
cells.
Researchers at the University of Cambridge have managed to reconstruct the
early stage of mammalian development using
embryonic stem
cells, showing that a critical mass of
cells — not too few, but not too many — is needed for the
cells to being self - organising into the correct structure for an embryo to form.
In a developing embryo PGC's can be isolated from the germinal crescent, a region in the
early stage embryo where the
cells form, or from the gonads at a later
stage in
embryonic development.
They included cloning (somatic
cell nuclear transfer, accomplished in many placental mammals), stem
cell gametogenesis (has been done in mice), direct engineering of
early stage embryos (has been done in several mammals),
embryonic stem
cell editing, and primordial germ
cell (PGC) editing.
In the future, these
cells could be molecularly manipulated to better grasp their interactions and the
early embryonic development
stages, hypothesizes Dr. Christos Coutifaris, president - elect of the American Society for Reproductive Medicine and a professor at the University of Pennsylvania.
Embryonic Stem Cells: While bone marrow donor centers were being established in the 1980s, another stem cell family tree branch was developing that would draw much attention: Nearly 30 years ago, embryonic stem cells were isolated from early - stage mouse
Embryonic Stem
Cells: While bone marrow donor centers were being established in the 1980s, another stem cell family tree branch was developing that would draw much attention: Nearly 30 years ago, embryonic stem cells were isolated from early - stage mouse emb
Cells: While bone marrow donor centers were being established in the 1980s, another stem
cell family tree branch was developing that would draw much attention: Nearly 30 years ago,
embryonic stem cells were isolated from early - stage mouse
embryonic stem
cells were isolated from early - stage mouse emb
cells were isolated from
early -
stage mouse embryos.
These human
embryonic stem
cells (hESCs) are isolated from
early stage embryos.
The process of obtaining
embryonic stem
cells results in the destruction of an
early -
stage human embryo.
These genes have been also implicated in the gastrulation phase of embryogenesis [55] indicating that «Time Series» clusters provide a comprehensive collection of genes expressed at specific
stages of ES
cell differentiation and
early embryonic development.
In a developing embryo PGC's can be isolated from the germinal crescent, a region in the
early stage embryo where the
cells form, or from the gonads at a later
stage in
embryonic development.