Sentences with phrase «cell engineering»

Hence, development of technologies capable of effectively overcoming these barriers for delivery of cell engineering materials, while preserving critical cell functions, is vital to success.

Such materials can be patterned with live cells engineered to sense environmental chemicals and pollutants as well as changes in pH and temperature.

Another possibility is attaching the contrast agent to immune cells engineered to attack a patient's tumor, allowing the cells to be tracked inside the body.

According to the Nature Biotechnology study co-authors, this strategy of analyzing molecules in single cells is likely to find favor not only among researchers who explore how specialized cells arise at specific times and locations within the developing organism, but also among those who monitor cell characteristics in stem cells engineered for tissue replacement, and those who probe the diversity of cells within tumors to identify those responsible for survival and spread of cancerous cells.

Novocell, Inc. is a stem cell engineering company with product development operations in San Diego, California and Athens, Georgia.

We are investigating this T cell response in newly generated CD1c transgenic mice, and developing an «off - the - shelf» adoptive cell therapy strategy with T cells engineered with CD1c - restricted, leukemia - specific TCRs, which can be applied to all patients with CD1c + leukemia recurrence following bone marrow transplantation.

BERKELEY, CA, and CORALVILLE, IA — February 23, 2016 — Caribou Biosciences, Inc., a developer of CRISPR technologies for precision cell engineering, and Integrated DNA Technologies, Inc. (IDT), a producer of custom synthetic oligonucleotide - based technologies for genomics applications, have entered into a non-exclusive license agreement under which Caribou has granted IDT worldwide rights to commercialize CRISPR - Cas9 reagents under Caribou's intellectual property.

A team of researchers at the University of Queensland has developed a new process that has successfully silenced a severe allergic response in mice, using blood stem cells engineered with a gene that can target specific immune cells.

Lu provided the team with bacterial cells engineered to light up in response to a variety of chemical stimuli.

Dr. Sadelain's research focuses on human cell engineering and cell therapy to treat cancer and hereditary blood disorders.

«Custom blood cells engineered by researchers.»

In experiments with mice, the researchers found that Paneth cells engineered to lack a functional ATG16L1 gene were five times more likely to die in the face of rising TNF - alpha signals than normal cells.

WASHINGTON — Immune cells engineered to hunt and destroy cancer cells may help some people with acute lymphoblastic leukemia (ALL) live much longer.

«This paper is a great example of how chemistry can help make step changes in biology,» says Matthew Dalby, a professor of cell engineering at the University of Glasgow and co-senior author on the study with Ulijn.

In tests on human brain cells engineered to make more normal prions than usual, Hooper found that the cells secreted far less amyloid beta peptide than they would ordinarily.

So we might just be able to deal with cell loss if we had a sufficiently sophisticated program of stem cell replenishment — using cells engineered to lack the one linchpin function for cancer, namely telomere elongation.

They also envision their technique may be used to manufacture drug capsules and surgical implants, containing cells engineered produce compounds such as glucose, to be released therapeutically over time.

To see if any of the doubly flawed genes would make working proteins, the researchers inserted them into yeast cells engineered to not grow unless a functioning p53 protein was present.

The altered virus was unable to infect feline cells engineered to produce human TRIM5α, the group reports online today in Science.

The team first tested the antibody in cultured cells engineered to express the Nav1.7 sodium channel.

Next, the scientists made a mouse model with fat cells engineered to make a certain microRNA that is found in humans, but not mice, and showed that these human microRNAs could also regulate their target in the livers of the mice and that this was do to these circulating exosomal microRNAs.

He and his colleagues showed that nerve cells engineered to produce amyloid - beta were better able than other cells to stand up to the infectious Candida albicans, a fungus.

Finally, his discussion covers the genetic manipulation of induced pluripotent stem cells (iPSCs) to derive NK cells engineered to express modified CD16A, and their potential for improving the efficacy of tumor - targeting therapeutic mAbs.

«We are delighted to have attracted such an impressive group of investors that share our enthusiasm for the vast potential of our proprietary CRISPR - Cas9 - based cell engineering platform,» said Rachel Haurwitz, Ph.D., Chief Executive Officer and co-founder of Caribou Biosciences.

Relapsed or refractory chronic lymphocytic leukemia and acute lymphoblastic leukemia patients have shown durable responses of almost 2 years to a novel T - cell engineering technique developed at the University of Pennsylvania Perelman School of Medicine in Philadelphia.

These are exciting advancements, but the most viable method remains in vitro primordial germ cell engineering — making genome edits in germ cells in a «petri dish».

We also support he bespoke stem cell engineering team, which does not rely on LIMS systems so much owing of the nature of their work.

MaxCyte's non-viral enabling technology for ex vivo cell engineering is the only technology capable of scaling from early - stage R&D to patient treatment and has been proven to meet the stringent demands of the clinic ---- used in 40 + partnered program, 15 + licenses for clinical development, and as part of a commercial immunotherapy.

The authors transplanted human cortical ‐ derived neural progenitor cells engineered to secrete glial cell line ‐ derived neurotrophic factor (GDNF) into the cortex of a rat model of ALS, where the cells migrated, matured into astrocytes, and released GDNF.

His gene therapy — delivering nanoparticles could transform patients into their own T - cell engineering labs, allowing them to be treated with reprogrammed T cells almost from the moment of diagnosis, skipping the waiting period and high cost of current approaches.

I specifically decided to pursue stem cell engineering after conducting biomaterials and biomechanics research as an undergraduate.

Mapping the expression profiles of all genes one cell at a time revealed unexpected heterogeneity in the stem cell - derived lung cells, and the research team at the CReM used this information to improve the airway cells engineered in the lab.

Novocell, Inc. is a stem cell engineering company with research and development operations in San Diego, California and Athens, Georgia, dedicated to creating, delivering and commercializing cell and drug therapies for diabetes.

Adoptive transfer of T cells engineered to express a chimeric antigen receptor (CAR) has emerged as a very promising type of targeted immunotherapy, with some studies showing complete remission rates as high as 90 % in relapsed and refractory acute lymphoblastic leukemia (ALL).

Caribou Biosciences, a developer of CRISPR - Cas9 technologies for precision cell engineering, today announced that co-founder Jennifer Doudna, Ph.D., has been named to TIME magazine's TIME 100 - TIME's annual list of the 100 most influential people in the world.

An artist's rendering of a bacterial cell engineered to produce amyloid nanofibers that incorporate particles such as quantum dots (red and green spheres) or gold nanoparticles.

Novocell, Inc. is a stem cell engineering company with research operations in San Diego, California and Athens, Georgia, dedicated to creating, delivering and commercializing cell and drug therapies for diabetes and other chronic diseases.

In a boon to stem cell research and regenerative medicine, scientists at Boston Children's Hospital, the Wyss Institute for Biologically Inspired Engineering at Harvard University and Boston University have created a computer algorithm called CellNet as a «roadmap» for cell and tissue engineering, to ensure that cells engineered in the lab have the same favorable properties as cells in our own bodies.

A baby's leukemia was successfully treated in 2015 with CAR - T cells engineered with gene editors known as TALENs.

On an additional project with former MIT graduate student Eric Grovender, Ameer co-developed a cartridge filter that purifies blood, «based on protein and cell engineering,» for those suffering from chronic kidney failure.

Cells engineered to produce insulin under the command of a smartphone helped keep blood sugar levels within normal limits in diabetic mice, a new study reports.

Nonetheless, for the researchers, «The success of our cell engineering experiments, which make it possible to produce nerve cells in a controlled and unlimited manner, and to transplant them, is a world first.

The reverse happened in cells engineered to make too few normal prions.

The two papers also clarify uncertainty around which methods are best for stem cell engineering, and should advance the use of cells derived from patient tissues to model disease, test potential drugs and use as treatments.

CellNet and its application to stem cell engineering are described in two back - to - back papers in the August 14 issue of the journal Cell.

The scientists first compared mouse megakaryocyte cells created from embryonic stem cells engineered to lack p45 - Nfe2 with normal megakaryocytes.