Sentences with phrase «cell engineering labs»

His gene therapy — delivering nanoparticles could transform patients into their own T - cell engineering labs, allowing them to be treated with reprogrammed T cells almost from the moment of diagnosis, skipping the waiting period and high cost of current approaches.

Not exact matches

He earned degrees in cell biology and tissue engineering and eventually got a job in a lab run by Vladimir Mironov, who was investigating the use of bioprinting — 3 - D printing using living cells — to generate replacement organs.

So far, researchers have mostly turned on genes with CRISPRa in cells growing in lab dishes, says Charles Gersbach, a biomedical engineer at Duke University not involved in the new study.

Alivisatos's nanotechnology lab is engineering quantum dots that could be embedded in the cell membranes of neurons.

To create the switch, biomolecular engineer Marc Ostermeier and colleagues marshaled a protein found in high levels in cancer cells to activate a second protein that he built in the lab.

Tissue engineers have been unable to grow epidermis with the functional barrier needed for drug testing, and have been further limited in producing an in vitro (lab) model for large - scale drug screening by the number of cells that can be grown from a single skin biopsy sample.

So Welham's team set out to engineer vocal fold mucosae in the lab using the two main cell types that make up the tissue — connective fibroblasts, which form the main body, and epithelial cells, which line the surface.

In a boon to stem cell research and regenerative medicine, scientists at Boston Children's Hospital, the Wyss Institute for Biologically Inspired Engineering at Harvard University and Boston University have created a computer algorithm called CellNet as a «roadmap» for cell and tissue engineering, to ensure that cells engineered in the lab have the same favorable properties as cells in our own bodies.

In my early years, I spent more time in the molecular biology lab, but I gradually moved into the biomaterial engineering lab as I got fascinated by the possibilities of combining biomaterials and cell biology.

Now head of her own lab at Stanford, Heilshorn engineers proteins to aid neural stem cells in healing injured brains and spines.

Zhao's team, working with bioengineers in Lu's lab, realized that live cells might also serve as responsive materials for 3D - printed inks, particularly as they can be genetically engineered to respond to a variety of stimuli.

Among the authors, only Charles Vacanti, an anesthesiologist and tissue engineering specialist based at Brigham and Women's Hospital in Boston, says his lab can make STAP cells.

These lab - engineered cells can then be amplified and grown out a hundredfold or more before being infused back in.

Wanting to pursue more experimental research, he headed to the Massachusetts Institute of Technology for a postdoc to join a lab of engineers who focused on cell and tissue culture experiments.

«We may have discovered a major step toward developing a «dream tool» for remotely controlling neural circuits, by manipulating specific cells using engineered gene products that respond to magnets,» said Ali Deniz Güler, a UVA biology professor who led the study in his neuroscience lab.

The work was performed in collaboration with Arjan Narbad's lab at the Institute of Food Research in Norwich, UK, who tested how engineering mutations in the endolysins affected their ability to tear down the bacterial cell wall.

Other co-authors on the study include James Bullock, a Berkeley Lab postdoctoral researcher in materials sciences, who was instrumental in engineering the system's photovoltaic and electrolysis cell pairing.

To produce CAR T - cells, doctors send a patient's blood to a lab where technicians isolate T - cells and engineer them to produce chimeric antigen receptors, or CARs.

A heart - on - a-chip being developed in the lab of Gordana Vunjak - Novakovic, professor of biomedical engineering at Columbia University, incorporates electrodes that act like mini pacemakers to «shock» the cells into beating, just as they would in a real heart.

I completed my PhD as a cell biology major in an engineering lab, where I established a new assay to answer questions very different from what the main part of the lab was working on.

Our lab broadly aims to understand how lipids modulate cell membrane function and to apply this knowledge to engineer synthetic biological systems from the bottom up.

However, advancements in engineering human stem cells are now allowing researchers to grow mini-organs in labs, and gene - editing tools can be used to insert specific mutations into these cells.

For example, by engineering PA - GFP tagged to a mitochondrial matrix protein (mito - PAGFP) the Youle Lab was able to visualize and quantify the fusion dynamics of mitochondria in healthy and apoptotic cells (9).

«I thought that if our team could find a way to simplify and better control that approach, we might be able to improve the way we engineer human brain cells in the lab.»

CAR - T cell therapy is a specific form of adoptive T cell transfer in which T cells are removed from the patient, genetically engineered in the lab to recognize a cancer antigen, expanded to billions of copies, and then returned to the patient.

Using a combination of engineered enzymes and chemical methods, Fasan's lab has further modified micheliolide to develop analogs — or variants — with improved activity against both active leukemia cells and leukemia stem cells.

Her lab is examining the potential of using biomaterials for stem cell differentiation and engineering mesenchymal tissues.

«The problem is that brain cells from actual people don't survive well in a dish, so we need to engineer human cells in the lab,» explained Gan, senior investigator at the Gladstone Institutes.

He decided to branch into other fields in his quest to better engineer cancer - destroying T cells and joined the lab of nanoparticle expert Dr. Darrell Irvine at the Massachusetts Institute of Technology.

In addition to checkpoint blockade antibodies, the editors also pointed to recent advances in adoptive cell therapy — removing a patient's immune cells, engineering them in the lab, and then re-infusing them back into the patient to fight cancer.

Mapping the expression profiles of all genes one cell at a time revealed unexpected heterogeneity in the stem cell - derived lung cells, and the research team at the CReM used this information to improve the airway cells engineered in the lab.

Stem cell lines grown in the lab provide scientists with the opportunity to «engineer» them for use in transplantation or treatment of diseases.

At Roswell Park, along with his translational lab research, Dr. Koya leads an NIH funded prospective clinical trial based on an immune - modulator - enhanced TCR - engineered T cell transfer for metastatic cancer patients.

Distilling the most radical accomplishments being made in labs worldwide, including gene therapy, genetic engineering, stem cell research, life extension, brain - computer interfaces, and cloning, More Than Human offers an exciting tour of the impact biotechnology will have on our lives.

The first solar cells, developed by Bell Labs in 1954, were inefficient (4 % conversion) and expensive, but they were a real engineering breakthrough.

Tags for this Online Resume: chemical engineering, computer modeling, chemical lab work, renewable energy, fuel cell, batteries

Professional Duties & Responsibilities Biomedical and biotechnology engineer with background in design of biomaterials, biosensors, drug delivery devices, microfrabrication, and tissue engineering Working knowledge of direct cell writing and rapid prototyping Experience fabricating nanocomposite hydrogel scaffolds Proficient in material analysis, mechanical, biochemical, and morphological testing of synthetic and biological materials Extensive experience in bio-imaging processes and procedures Specialized in mammalian, microbial, and viral cell culture Working knowledge of lab techniques and instruments including electrophoresis, chromatography, microscopy, spectroscopy, PCR, Flow cytometery, protein assay, DNA isolation techniques, polymer synthesis and characterization, and synthetic fiber production Developed strong knowledge of FDA, GLP, GMP, GCP, and GDP regulatory requirements Created biocompatible photocurable hydrogels for cell immobilization Formulated cell friendly prepolymer formulation Performed surface modification of nano - particle fillers to enhance their biocompatibility Evaluated cell and biomaterial interaction, cell growth, and proliferation Designed bench - top experiments and protocols to simulate in vivo situations Designed hydrogel based microfluidic prototypes for cell entrapment and cell culture utilizing computer - aided robotic dispenser Determined various mechanical, morphological, and transport properties of photocured hydrogels using Instron, FTIR, EDX, X-ray diffraction, DSC, TGA, and DMA Assessed biocompatibility of hydrogels and physiology of entrapped cells Evaluated intracellular and extracellular reactions of entrapped cells on spatial and temporal scales using optical, confocal, fluorescence, atomic force, and scanning electron microscopies Designed various biochemical assays Developed thermosensitive PET membranes for transdermal drug delivery application using Gamma radiation induced graft co-polymerization of N - isopropyl acylamide and Acrylic acid Characterized grafted co-polymer using various polymer characterization techniques Manipulated lower critical solution temperature of grafted thermosensitive co-polymer Loaded antibiotic on grafted co-polymer and determined drug release profile with temperature Determined biomechanical and biochemical properties of biological gels isolated from marine organisms Analyzed morphological and mechanical properties of metal coated yarns using SEM and Instron Performed analytical work on pharmaceutical formulations using gas and high performance liquid chromatography Performed market research and analysis for medical textile company Developed and implement comprehensive marketing and sales campaign