Sentences with phrase «cell engineering team»

We also support he bespoke stem cell engineering team, which does not rely on LIMS systems so much owing of the nature of their work.

Not exact matches

Brendan Frey, CEO of Deep Genomics and a biomedical engineering professor at the University of Toronto, says his research team trained its system to analyze individual cells to draw conclusions about the entire cellular system and, ultimately, make a diagnosis.

To see whether this also applies to humans, the team engineered stem cells from people with and without Down's syndrome and injected them into mice.

In an amazing feat of tissue engineering, Anthony Atala and his research team at the Children's Hospital in Boston are creating new organs in the laboratory using patients» own cells and by employing the same technology used to clone Dolly the sheep.

The engineered cells will circulate and, the team hopes, home in on the cancer, says Lu.

The team genetically engineered immune cells so that a calcium gate - controlling protein became light sensitive.

To determine the effect of mutations that reduce TET2 function in abnormal stem cells, the research team genetically engineered mice such that the scientists could switch the TET2 gene on or off.

When G - CSF activates its receptor, it ultimately activates proteins called STATs; the team engineered the cells to churn out the light - generating protein luciferase, which would be turned on by the STAT molecules.

To speed the search, the team had engineered a line of mouse cells to test for G - CSF - like activity.

The cells are held within a millimeter - scale table - top microbioreactor, containing a microfluidic chip, which was originally developed by Rajeev Ram, a professor of electrical engineering at MIT, and his team, and then commercialized by Kevin Lee — an MIT graduate and co-author — through a spin - off company.

So Welham's team set out to engineer vocal fold mucosae in the lab using the two main cell types that make up the tissue — connective fibroblasts, which form the main body, and epithelial cells, which line the surface.

The goal of the multi-institutional team is to develop genome engineering - based methods for correcting the disease - causing mutation in each patient's own stem cells to ensure that new red blood cells are healthy.

To deliver the healthy gene, the team inserted it into an engineered virus called adeno - associated virus 1, or AAV1, together with a promoter — a genetic sequence that turns the gene on only in certain sensory cells of the inner ear known as hair cells.

Once Katlyn arrived in May 2007, Candotti and his team removed stem cells from her bone marrow and exposed them to the engineered retrovirus, creating a human - virus hybrid.

In addition to using normal breast cancer cells in the experiments, the team also used cancer cells that had been genetically engineered to lack either GSTO1 or RYR1.

To engineer an APC - mimetic scaffold, the team first loaded tiny mesoporous silica rods (MSRs) with Interleukin 2 (IL - 2)-- an APC - produced factor that prolongs the survival of associated T cells.

While teams used a variety of engineering strategies to enhance their cells» chemotactic ability, the most successful cells were an adapted version of Dicty with increased activity of a particular protein, Ric8, that enhanced G - protein signaling, helping chemotaxis in shallow chemical gradients.

June's team also wants to knock out two gene segments that encode different portions of the protein that makes up a T cell's primary receptor so that the engineered NS - ESO - 1 receptor will be more effective.

The team of medical and engineering researchers at The Ohio State University previously determined that modifying a single gene to reduce this protein's level in breast cancer cells lowered the cells» ability to migrate away from the tumor site.

Fourteen participating teams each engineered two chemotaxis models, the amoeba Dictyostelium discoideum (Dicty), and the human cell line HL60, to run a millimeter - long maze of interconnected, orthogonal channels designed to mimic the cell's natural environment.

Interestingly, when the team stimulated sour cells with light, they did not observe that kind of aversive behavior in the engineered mice.

Shah and his team induced toxin resistance in human neural stem cells and subsequently engineered them to produce targeted toxins.

To turn this into something that could one day be a viable therapy for people, the team took stomach stem cells from diabetic mice, engineered them with the same genes and grew mini-organs.

Emotiv solved this brain — computer interface problem with the help of a multidisciplinary team that included neuroscientists, who understood the brain at a systems level (rather than individual cells), and computer engineers with a knack for machine learning and pattern recognition.

A team led by neuroscientist Khalid Shah, MS, PhD, who recently demonstrated the value of stem cells loaded with cancer - killing herpes viruses, now has a way to genetically engineer stem cells so that they can produce and secrete tumor - killing toxins.

Now a team of engineers at MIT has developed a new way to deliver such vaccines directly to the lymph nodes, where huge populations of immune cells reside: These vaccines hitch a ride to the lymph nodes by latching on to the protein albumin, found in the bloodstream.

Dr. Zhou and his team genetically engineered dendritic cells with a light - sensitive calcium gate - controlling protein.

Even more encouraging, the engineered tissues still continued to produce human neural, cartilage, and liver cell proteins, the team reports online this week in the Proceedings of the National Academy of Sciences.

Zhao's team, working with bioengineers in Lu's lab, realized that live cells might also serve as responsive materials for 3D - printed inks, particularly as they can be genetically engineered to respond to a variety of stimuli.

So when an international team of engineers wanted to design tiny robots that could move cells around, deliver drugs deep inside the body or clean clogged arteries, they looked to nature for inspiration: sperm.

Lu provided the team with bacterial cells engineered to light up in response to a variety of chemical stimuli.

A team of engineers at MIT has harnessed viruses to make components for a remarkable new kind of battery, half the size of a human cell and far more efficient than your usual AAA.

The team now plan to genetically engineer healthy cells to produce the same metabolic behaviour.

Using a combination of human or specially engineered mouse cells in vitro and in vivo animal models, study senior investigator Judy Lieberman, MD, PhD; study lead investigator Farokh Dotiwala, PhD, with a team lead by the Brazilian parasitologist Ricardo Gazzinelli, DSc, DVM, found that when an immune killer cell, such as a T - cell or natural killer (NK) cell, encounters a cell infected with any of three intracellular parasites (Trypanosoma cruzi, Toxoplasma gondii or Leishmania major), it releases three proteins that together kill both the parasite and the infected cell:

In the phase I / II clinical trial of 20 patients, the engineered cells were deemed safe, trafficked to the site of the tumor (bone marrow), and persisted in 90 percent of the patients who reached two years follow up after infusion, the research team found.

Now, as a proof of principle, Chin's team has engineered fruit flies that incorporated three new amino acids into proteins in the cells of their ovaries (Nature Chemical Biology, DOI: 10.1038 / nchembio.1043).

To bypass the challenge, the team relied on their complementary expertise in genome engineering, stem cell differentiation into neurons, and genomic analysis of alternative splicing.

Ngai's group teamed up with UC Berkeley statisticians and computer scientists — led by Sandrine Dudoit, a professor of biotstatistics and statistics, Elizabeth Purdom, a professor of statistics, and Nir Yosef, a professor of electrical engineering and computer sciences — to develop a way to analyze the experimental data and identify cells with similar RNA profiles, indicative of specific cell types and developmental states.

The team first tested the antibody in cultured cells engineered to express the Nav1.7 sodium channel.

To find out, the team engineered baby hamster kidney cells to express the human ACE2 receptor.

In an effort to overcome these limitations, a team at the Wyss Institute for Biologically Inspired Engineering led by its Founding Director, Donald Ingber, M.D., Ph.D., had previously engineered a microfluidic «Organ - on - a-Chip» (Organ Chip) culture device in which cells from a human intestinal cell line originally isolated from a tumor were cultured in one of two parallel running channels, separated by a porous matrix - coated membrane from human blood vessel - derived endothelial cells in the adjacent channel.

Today, at 56, Atala oversees 300 researchers and support personnel, including chemists, biologists and engineers divided into different teams working on cell therapy, a technology for what he calls partial transplants and the creation of new organs.

By engineering red blood cells to have «sticky» proteins on their surface, a team of researchers has given the cells the ability to carry anything from drugs to treat immune disorders or cancer to radioactive molecules used in imaging of blood vessels.

The research team thinks mimicking the approach could yield some new high - strength adhesives — and might even work in tissue engineering to stick cells to scaffolds when building artificial organs.

Knowing that Notch governs vessel permeability makes it a candidate for new drugs to treat cardiovascular diseases as well, and the team is also investigating the TMD as a potential therapeutic agent itself, as cell models that were exposed to leak - inducing inflammation displayed a dramatic reduction in leakage when they were engineered to express the TMD.

In a previous study (Applied Physics Letters, Volume 103, Issue 2, 021116 (2013)-RRB- the research team of David R. Barbero already demonstrated that nano - engineered networks can be produced onto thin and flexible transparent electrodes that can be used in flexible solar cells.

After outfitting the nanoparticles with their molecular assistants and engineering the cell membranes to receive the nanoparticles, the team applied a solution of nanoparticles to the cell cultures and switched on a magnetic field.

Several research teams had reasoned that if yeast cells could be engineered to express mannosidase, the cells wouldn't produce the mannose - rich sugar complexes that are so immunogenic to humans.

A research team has come up with a way of genetically engineering the DNA of mammalian cells to carry out complex computations, in effect turning the cells into biocomputers.

When the team genetically engineered female mice to be unable to make these NK cells, the animals had fetuses that were half normal size.