Sentences with phrase «cell epigenetic profile»
«We were surprised that the exhausted T cell epigenetic profile was not reprogrammed,» Wherry said.
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The Epigenetics Research group used these cells to perform genome - wide profiling across more than 20,000 individual genes in these patients.
«What these new findings on exhausted T cells tells us is that the unique epigenetic profile of exhausted T cells causes these cells to express a different overall set of genes compared to memory or effector T cells,» Wherry said.
The team found that exhausted T cells acquired an epigenetic profile distinct from effector or memory T cells.
In this study, published in the journal Cell Reports, and led by Dr. Esteban Ballestar (IDIBELL), the comparison of the epigenetic profiles between dendritic cells and myeloid - derived suppressor cells has allowed them to identify the existence of specific epigenetic alterations that associated with the development of myeloid - derived suppressor cells as a result of exposure to prostaglandin E2.
Since HIV infection itself alters epigenetic processes in the immune system, the research team wondered whether a distinct DNA methylation profile, a major epigenetic modification where methyl groups are added to DNA, occurs in those with HIV associated - cognitive impairment and whether it exists in distinct immune cell populations from the blood.
Current explorations into the molecular underpinnings of cell circuitry are leveraging multiple data types including expression profiling and epigenetic analysis leveraging RNA - seq and CHiP - Seq coupled with molecular markers and cellular phenotypes.
A number of recent articles, however, have reported that hiPSCs are, in fact, notably distinct from human embryonic stem cells in terms of their gene expression, epigenetic profile, proliferative capacity and the susceptibility of their differentiated progeny to cellular senescence and apoptosis [3 — 6].
Another group investigated CD8 + T cells, and found that babies had epigenetic and gene expression profiles that resembled those of innate immune cells, which «may provide a partial explanation for infants» higher susceptibility to infectious pathogens,» GenomeWeb reported.
Causes and consequences of epigenetic changes, transcriptional profile modulation and new genetic profiles drive the single cell towards its destiny, contributing to the complexity of the multicellular organism or cell colony.
De Jager said that researchers are devising ways to eke out epigenetic profiles from single cells, which would ultimately simplify the comparison of different neuronal types.