Sentences with phrase «cell exosomes»

Not exact matches

The startup describes itself as a deep data platform for the study of exosomes, which are small lipid vesicles — air - or fluid - filled cavities — that are excreted from cells and which deliver information that Mantra plans to use to come up with new drug therapies.

The other two major targets in the field, circulating tumor cells and exosomes, come with their own challenges.

«There are these microvesicles called «exosomes» that are actually released from every living cell in the body.

Those cells naturally bud off exosomes — tiny bubbles made of cell membrane — that carry the virus inside them.

«When we block the path into the cell, we also block the functional effects of the exosomes.

How do the exosomes get into the recipient cells?

The Lund researchers» discovery is the exosomes» journey from the sender cell to the receiver cell and how the receiver cell captures and internalizes the exosomes.

The focus of their research is «exosomes», small virus - like particles that serve as «transport packages» for genetic material and proteins transmitted between cells.

In this way, the mechanism by which exosomes enter cells resembles the spread of viral infections,» says Helena Christianson, doctoral student in Belting's research team and first author of the study.

The importance of exosomes in the tumour microenvironment has been demonstrated within the field in recent years, as it has been shown that tumour development is halted if the production of exosomes inside the cancer cell is stopped.

The team showed that exosomes could serve as an efficient carrier of RNAi, given that these nano - sized vesicles easily travel across the body and enter cells, including cancer cells.

At first it was thought that only functioned as cellular debris warehouses but in recent years has been that could have an important role as a messenger between cells of the body and now many groups focus their research on the role that could be played exosomes in various diseases, including cancer.

The team also showed that the cellular process macropinocytosis, which participates in cell scavenging nutrients and vesicles, contributes to exosomes uptake in cancer cells with mutant KRAS.

These improvements push the boundaries of nucleic - acid detection and fragment sizing, affecting applications such as single - cell nucleic acid analysis, PCR - free preparation of NGS library preparation, bacterial artificial chromosome clone sizing, and exosome analysis.

Exosomes are small vesicles which are secreted by all cells and contain proteins and messenger RNAs and microRNAs.

He's also looking at the impact on the ability of trabecular meshwork cells to make and send out fluid - filled pockets called exosomes that may enable the cells to communicate.

Genetic manipulation of exosomes, virus - sized particles released by all cells, may offer a new therapeutic approach to treating pancreatic cancer, according to a study at The University of Texas MD Anderson Cancer Center.

Researchers at the Bellvitge Biomedical Research Institute of Bellvitge, the Catalan Institute of Oncology and the University Hospital of Bellvitge have participated in an international study published in the journal Cancer Cell that describes how exosomes secreted by tumor cells contain protein and microRNA molecules capable of transform neighboring cells into tumoral cells promoting tumor growth.

The investigators utilized a targeting method called RNA interference (RNAi) which, when delivered via these natural nanoparticles or exosomes, zero in on mutant KRAS in pancreas cancer cells, impacting tumor burden and survival in multiple pancreas cancer models.

In the study, exosomes, which are generated by all cells and are naturally present in blood, were modified as «iExosomes,» capable of delivering small RNA to specifically target mutant KRAS, resulting in disease suppression and increased overall survival in mouse models.

According to the head of the research group of chemoresistance and Predictors of tumor response and stromal environment ICO - IDIBELL, Alberto Villanueva, «tumor exosomes contain certain proteins (Dicer, TRBP and Ago2) able to process microRNAs that can alter the around the tumor cells transforming them into tumoral cells.»

Further study is needed to gain a better understanding about whether exosomes entering cells via macropinocytosis have other features that could enhance their anti-tumor capabilities.»

The study published in Cancer Cell shows that exosomes from tumor cells of breast cancer (and other tumor types such as ovarian and endometrial) are different in size and composition than those of healthy cells.

«We identified how CD47 contributes to suppressing exosomes clearance from circulation, and enhancing their delivery to pancreatic cancer cells.»

However, in the past decade scientists realized that exosomes play important roles in many biological functions through capsuling and delivering molecular messages in the form of nucleic acids and proteins from the donor cells to affect the functions of nearby or distant cells.

«Exosomes are minuscule membrane vesicles — or sacs — released from most, if not all, cell types, including cancer cells,» said Yong Zeng, assistant professor of chemistry at the University of Kansas.

«The increased number of exosomes reaching the pancreas may gain further advantage to enter KRAS - associated cancer cells as a result of enhanced macropinocytosis, which concurs with previous findings,» said Kamerkar.

The researchers hypothesize that the exosomes caused the hMSCs to differentiate by delivering miRNA into the stem cells.

Tufts University biomedical engineers recently published the first report of a promising new way to induce human mesenchymal stem cells (or hMSCs, which are derived from bone marrow) to differentiate into neuron - like cells: treating them with exosomes.

Exosomes had not previously been studied as a way to induce human stem cell differentiation.

«New way to repair nerves: Using exosomes to hijack cell - to - cell communication.»

Exosomes are very small, hollow particles that are secreted from many types of cells.

In a series of experiments reported in PLOS ONE in August, the Tufts researchers showed that exosomes from PC12 cells (neuron - like progenitor cells derived from rats) at various stages of their own differentiation could, in turn, cause hMSCs to become neuron - like cells.

The biomedical engineers also showed that the exosomes contain miRNAs — tiny pieces of RNA that regulate cell behavior and are known to play a role in neuronal differentiation.

In lab experiments, the researchers isolated exosomes from specialized human cardiac stem cells and found that exosomes alone had the same beneficial effects as stem cells.

Exosomes transport small pieces of genetic material, called microRNAs, that enable cells to communicate with neighboring cells to change their behavior.

«The concept of exosome therapy is interesting because it could potentially shift our strategy from living - cell transplantation to the use of a non-living agent,» he added.

We have found that exosomes and the cargo they contain are crucial mediators of stem cell - based heart regeneration, and we believe this might lead to an even more refined therapy using the «active ingredient» instead of the entire stem cell,» said Eduardo Marbán, MD, PhD, director of the Cedars - Sinai Heart Institute and a pioneer in developing investigational cardiac stem cell treatments.

«The exosomes appear to contain the signaling information needed to regenerate healthy heart tissue, they are naturally able to permeate cells, and they have a coating that protects their payloads from degradation as they shuttle from cell to cell,» said Marbán, senior author of an article in the May 6, 2014 Stem Cell Repocell to cell,» said Marbán, senior author of an article in the May 6, 2014 Stem Cell Repocell,» said Marbán, senior author of an article in the May 6, 2014 Stem Cell RepoCell Reports.

Dr. Batrakova's group investigates the development of personalized drug delivery systems, including using living cells or exosomes released from these cells that are loaded with therapeutics.

Exosomes — small, membrane - derived extracellular vesicles capable of carrying diverse biological cargo including proteins and microRNAs — have been found in a broad range of biological fluids and appear to be predominantly involved in cell - to - cell communication.

In addition, exosomes are being co-opted as a treatment modality and have been modified through their parental cells to express a targeting moiety or marker tag on their surface.

Insights gained into the underlying biology of metastatic basal cell carcinoma obtained via exosome RNA sequencing

The role of rebiopsy and repeat analysis in the setting of post-treatment relapse, along with testing of blood samples for mutations in circulating tumor cells, cell free tumor DNA, or exosomes will be considered.

Recently, however, ephrins and Eph receptors have also been found in extracellular vesicles / exosomes — small droplets of fat released by cells, used as transport vehicles, signal transmitters or for eliminating cell components.

Ephrins and Eph receptors have also been found in the exosomes of cancer cells.

They termed these bodies «oviductosomes,» from «oviduct,» which is another name for the fallopian tube, and «exosomes,» the teeny sacs found in all the body's fluids that help cells survive.

Intrigued, the Martinsried - based team set up an elaborate experimental study to purify the exosomes from different cell types, including neurons, and analyse their contents.

Exosomes form inside cell compartments and release outside the cell when these compartments fuse with the cell's surrounding membrane.

According to Haughey, after many failed experiments to determine the brain's messenger, he visited his colleague and collaborator Daniel Anthony at Oxford University, who introduced him to the concept of «exosomes» — miniature vesicles released from cells.