Sentences with phrase «cell expansion by»

The study, «Anti-TNF drives regulatory T cell expansion by paradoxically promoting membrane TNF - TNF - RII binding in rheumatoid arthritis,» which will be published online June 6 in The Journal of Experimental Medicine, may help explain the divergent efficacies of different TNF - targeting drugs.

Not exact matches

Perhaps, Clavería says, cell expansion driven by Myc sets the stage for a tumor.

In a series of side - by - side comparisons, Mooney's team demonstrated that APC - mimetic scaffolds performed better than methods involving commercially available expansion beads (Dynabeads), which are currently used in clinical adoptive cell transfer approaches.

They report that CD4 - CTLs undergo significant clonal expansion and that CD4 - CTL precursor cells are characterized by high expression of interleukin - 7 receptor.

«We have discovered the key role played by the TOR signalling pathway in driving the expansion of the endoplasmic reticulum, and sending a cell's factories into overdrive.

The approach enabled a wide range of studies of human brain development, including implicating a new class of neural stem cell recently discovered by the lab in the evolutionary expansion of the human brain and identifying how the mosquito - borne Zika virus may contribute to microcephaly in infants infected in utero.

Because the anticancer compound works by binding to troublesome expansions in DNA, the researchers decided to test whether it would work in cells and a mouse model of myotonic dystrophy type 1.

The authors uncover the cellular and molecular mechanisms, as well as the gene network regulated by Sox9 during the early steps of skin tumor initiation and demonstrates that Sox9 controls the long term maintenance and expansion of oncogene expressing cells by promoting self - renewing division and inhibiting differentiation.

Cédric Blanpain, MD / PhD, professor and WELBIO investigator at the IRIBHM, Université libre de Bruxelles, Belgium, report that Sox9, directly controls skin cancer formation by regulating the expansion of tumor initiating cells and the invasive properties of cancer cells.

Even though STAT3 activity drives the expansion of MDSCs and is involved in immune responses mediated by the cells, they found that high levels of STAT3 activity actually prevent the differentiation of MDSCs to macrophages.

In cancer, a state marked by increased protein translation and biomass expansion, HSF1 is activated and binds to numerous genes throughout the genome, as seen in the heat map of HSF1 ChIP - Seq read density in M0 - 91acute myeloid leukemia cells (DMSO, far left).

By combining SNP - targeting allele - specific silencing and gain - of - function approaches, we showed that a 46 - glutamine expansion in human HTT was sufficient for a dominant - negative effect on spindle orientation and changes in the distribution within the spindle pole and the cell cortex of dynein, p150Glued and NuMA in neural cells.

Using a novel technique to genetically modify T cells for adoptive transfer, Carl June, Michael Kalos, David Porter, Bruce Levine, and colleagues at the University of Pennsylvania School of Medicine achieve clinical responses in patients with chronic lymphocytic leukemia, including two complete, durable (one year) clinical responses, accompanied by in vivo expansion and long - term functional persistence of gene - modified cells.

An expansion of an ES cell clone is a minimal service and does not include verification of the identity of the ES cell line by DNA sequencing.

Expansion of embryonic and adult neural stem cells by in utero electroporation or viral stereotaxic injection.

Since BRs are not transported long distances, they act locally to promote growth by enhancing cell elongation and / or expansion (Symons and Reid, 2004; Symons et al., 2008).

Expansion and maintenance of human embryonic stem cell - derived endothelial cells by TGFbeta inhibition is Id1 dependent.

Stem cell polarity is established by the PAR complex, comprised of PAR3 / PAR6 / aPKC, to regulate self - renewal and expansion.

Promoting survival and proliferation at the single - cell level is critical for expansion of any clonal colonies containing the mutation of interest generated by the gene editing process.

Although the Badovinac study does mention that immunization of B6 Prf1 − / − mice followed by LCMV infection results in mortality with LCMV - specific CD8 T cell expansion (as do naive B6 Prf1 − / − mice), these data were not shown as the focus of the report was on the BALB / c model.

During tumor development, rapid expansion of cancer cells creates a hypoxic microenvironment that is followed by periods of reoxygenation to promote tumor progression.

Bone marrow - derived mesenchymal stem cells (BM - MSCs) are obtained by isolating mononucleated cells from a marrow aspirate by centrifugation on a density gradient, followed by adherent cell expansion in tissue culture.

Review of «Inhibition of Methyltransferase Setd7 Allows the In Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential» from Cell Stem Cell by Stuart P. Atkinson

Requested cell lines are tested by PCR analysis for mycoplasma spp. and Murine Parvoviruses (MPV) upon completion of expansion and prior to shipment.

T and B cell clonal expansion in Ras associated lymphoproliferative disease (RALD) as revealed by next generation sequencing

In vitro expansion of single Lgr5 + liver stem cells induced by Wnt - driven regeneration.

The kinetics of the acute response were characterized by rapid expansion of activated T cells, followed by a contraction phase.

Due to the large number of hES cells and human induced Pluripotent Stem (hiPS) cells needed by I - Stem's research groups, the development of large - scale culture systems for expansion and differentiation of those cells is critical.

The notion that a Nanog positive, ICM - like population of high probability self - renewing cells is a developmental ground state is supported by the expansion of this state in the presence of a blockade on the major signalling pathways known to promote ES cell differentiation, the MAP kinase / ERK cascade and GSK3β [42], [50].

The first step in both direct and cell - based gene therapy is packaging a therapeutic transgene into a delivery vehicle (e.g., a viral vector), followed by expansion of its host cell lines to produce high - enough vector concentrations.

Inspired by XBP - 1's roles in maintaining a homeostatic ER, the lab began to examine the role of XBP - 1 in B - cell leukemia whose progression does not require dramatic ER expansion like that in multiple myeloma.

First, when GLA is accompanied by a tumor antigen and injected into a patient, the combination is taken up by the DCs and leads to the production and expansion of immune cells called CD4 helper T cells.

Most cancers evolve from a single founder cell through a series of clonal expansions that are driven by somatic mutations.

Here, authors from Corning Life Sciences describe dissolvable microcarriers as a scalable solution for large - scale expansion and harvest of functional human mesenchymal stem cells by enabling simplified downstream processing and high - yield cell recovery.

No significant differences were seen between the normoxic and hypoxic anoikis - resistant populations collected from MCF7 cells and a single significant gene change (PIP) was seen in T47D (Table 1) suggesting that the CSC - enriched population remains virtually unchanged following hypoxic culture and the increase in MFC, HFC, and tumor initiating cells is, therefore, due to expansion of the population, perhaps by increased symmetric self - renewal of the CSC or de-differentiation of early progenitor cells, rather than simply the acquisition of anoikis resistance in non-CSC.

Instead, a very small number of neurons specifically activated by learning show an expansion of structure that's both surprisingly extensive — there's a dramatic increase in the size and complexity of the affected neurons — and yet highly restricted to a small subset of cells.

It acts as a «volumizer» or «cell expansion» product by pulling water into the muscle cell, causing it to expand, which results in a remarkable increase in size and muscular strength.

Here we are talking about modification of atmospheric circulation — poleward expansion of the dry, descending portion of the Hadley Cell circulation by a few degrees, associated shifts in the jet stream.

(21) «Construction of the first cell in the expansion plan (Phase I) was completed and approved for use by the Ohio EPA in December of 2000 at cost of $ 3,300,000.

What they discovered was that the poleward shift of the clouds, which occurs in both the Northern and Southern Hemispheres, connected more strongly with the expansion of the tropics, defined by the general circulation Hadley cell, than with the movement of the jets.