Sentences with phrase «cell expansion following»
In that paper, Weitzmann, Ofotokun, and their colleagues described bone loss similar to that observed in humans following the reconstitution of the T cell population in immune - compromised mice (similar to T - cell expansion following ART).
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Another limitation observed with microcarriers is the difficulty to efficiently dissociate cells following cell expansion due to the strength of cell attachment to the micro ¬ carriers.
Although the Badovinac study does mention that immunization of B6 Prf1 − / − mice followed by LCMV infection results in mortality with LCMV - specific CD8 T cell expansion (as do naive B6 Prf1 − / − mice), these data were not shown as the focus of the report was on the BALB / c model.
During tumor development, rapid expansion of cancer cells creates a hypoxic microenvironment that is followed by periods of reoxygenation to promote tumor progression.
Bone marrow - derived mesenchymal stem cells (BM - MSCs) are obtained by isolating mononucleated cells from a marrow aspirate by centrifugation on a density gradient, followed by adherent cell expansion in tissue culture.
The kinetics of the acute response were characterized by rapid expansion of activated T cells, followed by a contraction phase.
The first step in both direct and cell - based gene therapy is packaging a therapeutic transgene into a delivery vehicle (e.g., a viral vector), followed by expansion of its host cell lines to produce high - enough vector concentrations.
No significant differences were seen between the normoxic and hypoxic anoikis - resistant populations collected from MCF7 cells and a single significant gene change (PIP) was seen in T47D (Table 1) suggesting that the CSC - enriched population remains virtually unchanged following hypoxic culture and the increase in MFC, HFC, and tumor initiating cells is, therefore, due to expansion of the population, perhaps by increased symmetric self - renewal of the CSC or de-differentiation of early progenitor cells, rather than simply the acquisition of anoikis resistance in non-CSC.