The role of these molecules in driving disease pathology might
vary, with described activities of HVEM signaling promoting T
cell expansion or survival, analogous to certain activities of OX40 and 4 - 1BB, and other activities of HVEM or LTβR increasing the function of diverse
cells such as stromal
cells, dendritic
cells, macrophages, eosinophils, epithelial
cells and keratinocytes.
Against that we have observational evidence that the polar high pressure
cells do
vary from influences above and until there is another explanation I'll go with the solar /
expansion idea but any idea that demonstrably works is good enough for me.