Sentences with phrase «cell factors identified»
First author Dr Reza Haqshenas said the researchers then used gene silencing technology to determine whether the genes» cell factors identified using the antibody microarray were indeed important for HCV replication and therefore potential targets for anti-HCV compounds.
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By overlaying that information onto a computer model of the whole human genome, they were able to identify key factors involved in cell regulation
Mahmoudi and his colleagues previously identified several others overlooked biological factors that appear to contribute to discrepancies seen between results in the lab and in the clinic, including importance of personalized medicine at the nanobio interfaces, cell type, cell shape, and incubating temperature.
A new study by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) has identified a mechanism by which cancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibitors.
The current study was designed to clarify the cellular hierarchy underlying glioblastoma, to identify epigenetic factors that distinguish glioblastoma stem cells from more differentiated tumor cells and to suggest potential therapies targeting those factors.
In a series of experiments, the researchers first identified a set of 19 transcription factors that were expressed at significantly greater levels in cultured human glioblastoma stem cells capable of tumor propagation than in differentiated tumor cells.
Testing each of these factors for their ability to return differentiated tumor cells to a stem - like state, identified a combination of four — POU3F2, SOX2, SALL2 and OLIG2 — that was able to reprogram differentiated tumor cells back into glioblastoma stem cells, both in vitro and in an animal model.
«Transcription factors distinguishing glioblastoma stem cells identified.»
«Prognostic factors identified for peripheral squamous cell carcinomas of the lung.»
«We have now identified an essential host factor which when removed prevents all parasite strains from entering red blood cells.»
«By identifying the areas of the genome that are directly involved in the reprogramming, we have also identified an important factor in the process — the gene regulatory protein KLF11 (Kruppel Like Factor - 11), which is found in all fat cells, and we have shown that it is required for the reprogramming to take place.&factor in the process — the gene regulatory protein KLF11 (Kruppel Like Factor - 11), which is found in all fat cells, and we have shown that it is required for the reprogramming to take place.&Factor - 11), which is found in all fat cells, and we have shown that it is required for the reprogramming to take place.»
To understand defective disease process, investigators need to track where and how transcription factors bind to DNA to identify the differences between healthy and diseased cells.
«Over the last decade, geneticists have identified hundreds of genetic risk factors for several human diseases, but the functional consequences of those factors on relevant cells are largely unknown,» said Towfique Raj, PhD, BWH Department of Neurology and a postdoctoral scholar at the Broad Institute, lead study author.
Nevertheless, as Tobias says, it is still ``... a field beset with relatively few facts but many theories... The story of early hominid brains has to be read from carefully dated, well identified, fossilised calvariae, or from endocranial casts formed within them... Such materials confine the Hercule Poirot, who would read «the little grey cells» of fossil hominids, to statements about the size, shape and surface impressions... of ancient brains...» The other major limiting factor at the moment is the lack of suitable fossil skulls for such studies.
The current study identified a new role for a particular group of proteins, known as RFX transcription factors, in the development and survival of the hair cells.
The groundbreaking study identified a protein, known as cadherin - 22, as a potential factor in cancer metastasis, or spread, and showed that hindering it decreased the adhesion and invasion rate of breast and brain cancer cells by up to 90 per cent.
A neuro - oncology research team at Dartmouth's Norris Cotton Cancer Center, led by the Director Mark A. Israel, MD with first author Gilbert J. Rahme, PhD, recently identified the transcription factor Id4 as a suppressor of tumor cell invasion in glioblastoma.
With current techniques it is not easy to make comparative analysis of influenza viruses with single mutations in their genomes, and it is extremely difficult to identify factors that limit the reassortment process between two influenza genomes that have infected the same cell.
Analysis of PAL identified high levels of hydrogen peroxide, which is a known anti-tumor factor and the probable cause of cell death.
«This enabled us to identify the structural factors responsible for AH10 - 7's potency in activating iNKT cells.
An international consortium under the leadership of Prof. Dr. Thomas Laux, a biologist from the University of Freiburg, has identified the transcription factor WUSCHEL HOMEOBOX (WOX) 5 as the signal molecule, showing that it moves through pores from the cells inside the quiescent centre into the stem cells.
Scientists at Columbia University Medical Center (CUMC) have identified a factor in liver cells that is responsible for turning a relatively benign liver condition, present in 30 percent of U.S. adults, into a serious disease that can lead to liver failure.
In this new study, researchers employed a cell - based reporter system to screen a collection of over 1000 gene - regulatory factors called microRNAs for the ability to influence this transition and identified some with particularly potent effects.
But until now no one has been able to identify the factors affecting the reprogramming of precursor fat cells or establish the rapidity at which cells are reprogrammed.
«We have now found a novel source of cells that can differentiate into coronary vessels and have identified the factors required.»
«We used a mouse model of the KPro to, first of all, identify the inflammatory factors that cause damage to the eye, and then we also quantified the amount of nerve cell death in the back of the eye that mediates the optic neuropathy, and, lastly, we looked at blocking these factors with antibodies,» said Reza Dana, M.D., M.Sc., MPH, Director of the Cornea and Refractive Surgery Service at Massachusetts Eye and Ear and the Claes H. Dohlman Professor of Ophthalmology at Harvard Medical School.
The team from the Massachusetts General Hospital plans to use the microfluidic devices in synergy with some more sophisticated molecular biology tools and identify the control factors of cell migration speed.
The cell biologist helped explain how blood clots form by identifying factor XIII, the enzyme that binds proteins together to create a plug in a wound, preventing a person from bleeding to death.
«Identifying gene variants that are general risk factors for neurological and psychiatric disease is important, but understanding exactly which cell types in the developing brain are compromised and what the consequences are is still extremely challenging,» Pollen added.
«Research on Drosophila guided this work, and will be essential to identifying the specific human factors and their genes that re-program egg cells and make development possible.»
«Researchers identify key factor for reprogramming adult cells into stem cells.»
The new approach will allow scientists to induce mature human motor neuron development in cell culture, and to identify the factors that are vital to that process, Wang said.
The researchers identified a transcription factor called POU6F2, which is found in developing nerve cells in the retina and corneal cells in mice.
In a new Cell Reports paper, a team led by John P. Cooke, M.D., Ph.D., of the Houston Methodist Research Institute, has identified and characterized a biological factor critical to the transformation of adult somatic cells (cells that are not sperm or egg cells) into stem cells.
Periostin (POSTN) was identified by microarray RNA profiling studies as a stromal factor involved in maintaining the normal stem cell niche and demonstrated to be secreted by stromal fibroblasts, but not by infiltrating tumor cells (Malanchi et al., 2012).
«Work continues to identify the other factors, including small molecules, necessary to not only promote the maturation and survival of the newly generated hair cells, but also increase their number,» Zuo said.
By developing blood biomarkers and «immunologic signatures» related to antigen - specific T - cell responses, the researchers hope to identify individuals with latent TB infection who are at greatest risk for progression to active disease, allowing development of prevention strategies to target those at highest risk in areas with high rates of infection (usually low - and middle - income countries), as well as high income countries such as the U.S., where factors such as recent infection and HIV co-infection are associated with an increased risk of progression to active TB.
The resulting endothelial cell lines described in this study retain their phenotype after repeated passage, require minimal nutritional support and, importantly, may be useful for identifying factors that regulate endothelial cell proliferation and tumor cell adhesion in different anatomical regions.
A few years ago, Singh and colleagues identified a transcription factor called PU.1 that acts as the primary signal, a central genetic switch to initiate development of myeloid progenitor cells.
Researchers identify a network of a dozen transcription factors needed to maintain the pluripotent state of mouse embryonic stem cells.
Thomas Look and colleagues use a type of genomic screen and identify abnormal HGF expression as a crucial factor for development of a class of acute leukemia in leukemia cell lines and clinical samples.
Scientists at the Carnegie Institution have identified a gene, named scrawny, that appears to be a key factor in keeping a variety of stem cells in their undifferentiated state.
They also identified targets for potential therapies: bolstering levels of either a particular chaperone or a growth factor in brain cells can protect against the toxic effects of misfolded proteins.
Complementing this work are recent advances at Joslin identifying new islet growth in patients with long - standing type 1 diabetes, as well as identifying potential islet growth factors, which occur in situations of insulin resistance, that could be used to stimulate the growth of the patient's own beta cells.
The researchers identified 24 potential reprogramming factors — proteins that control whether other genes in the cell are turned on or off.
Of 17 regulatory variants identified in the two genes with regulatory variant burden, we show that at least six alter transcription factor - DNA binding in human neuroblastoma cells.
«We have identified the genes and growth factors involved and, thanks to a collaboration with Microsoft Research, we can now computationally model the control circuitry in mouse cells.
His team identified a factor that may be important for clinical trial design: progesterone was not toxic to all glioblastoma cell lines, and its toxicity may depend on whether the tumor suppressor gene p53 is mutated.
Dragomir Krastev (Buchholz, MPG)-- «An RNA interference synthetic interaction screen identifies vulnerability factors for TP53 mutant cells» (2009)
We have identified a number of key transcription factors that are deregulated during this process, and we are using this information to investigate mechanisms by which differentiation can be reprogrammed in tumour cells.