Sentences with phrase «cell failure in»

Ingestion of different sources of carbohydrate (such as rice) has been shown to increase the demand for insulin in cats and could potentially contribute to β - cell failure in susceptible cats when fed long term.

Activation of the NLRP3 inflammasome and secretion of its target interleukin - 1β (IL - 1β) have been implicated in pancreatic β cell failure in T2D.

Minireview: secondary β - cell failure in type 2 diabetes — A convergence of glucotoxicity and lipotoxicity

Using human pancreatic samples and mouse models, the HSPH researchers — with colleagues from Harvard Medical School, the Broad Institute of Harvard and MIT, and the Université Libre de Bruxelles — sought to tease apart the mechanisms of beta cell failure in T1D.

KULR Technology has reached agreement with the National Renewable Energy Laboratory (NREL) to be the exclusive manufacturing and distribution partner for the patented Internal Short Circuit (ISC) device which causes predictable battery cell failures in lithium - ion batteries, making them easier to study and, therefore, safer.

Not exact matches

When behavior is successful our cells become finely tuned to what the animal was learning at the time while a failure shows little change in the brain or improvement in the monkey's behavior.

In fact, the SEIA said, the plaintiffs were trying to blame Chinese cell and module makers for their own failure to turn in a profit because their products were subpar, while the Chinese suppliers were simply filling a critical gap amid booming demand for utility - scale solar installationIn fact, the SEIA said, the plaintiffs were trying to blame Chinese cell and module makers for their own failure to turn in a profit because their products were subpar, while the Chinese suppliers were simply filling a critical gap amid booming demand for utility - scale solar installationin a profit because their products were subpar, while the Chinese suppliers were simply filling a critical gap amid booming demand for utility - scale solar installations.

The Inquisitor eventually comes to visit him in his cell, mocks him, berates him, denounces him for his failure and the failure of the ideas of love [167] and servanthood and the exaltation of human freedom that he brought.

So we can also contemplate this same unfolding and unified purpose of Christ in our own lives, from our conception as a simple cell, ensouled by God in accordance with the Unity Law, to Baptism and entry into Christ in the Eucharist, through the years of growing up and formation in holiness and the spiritual life — maybe through failure and re-conversion.

It may now be possible to investigate whether the failure of mRNAs to move to the proper part of the cell — or a lack of balance between mRNAs in the high - and low - production areas of the cell — may play a role in such diseases as colitis and Crohn's disease, and possibly also in bowel cancer.

For example, he's used it along with a calcium - tracking dye in cardiac muscle cells from a rat, to image the sparks and waves of calcium ions that can trigger deadly arrhythmias during heart failure.

Previous failures in reprogramming primate cells probably happened because the egg ran into roadblocks — portions of the body cell's DNA known as reprogramming - resistant regions, say study coauthor Mu - ming Poo, director of the Institute of Neuroscience at the Chinese Academy of Sciences in Shanghai, and his colleagues.

Human embryonic stem cells are at last being tested in common, potentially fatal diseases such as heart failure and diabetes

Trials of cells made from human embryonic stem cells are also poised to begin in people with type 1 diabetes and heart failure, the first time embryonic stem cells have been used in the treatment of major lethal diseases.

Now a University of Colorado Cancer Center study published online ahead of print in the journal Oncogene offers compelling evidence explaining this failure and offering a possible strategy for the use of retinoic acid or other retinoids against some breast cancers: Because early clinical trials are often offered to patients who have already tried other more established therapies, breast cancer cells may have been pushed past an important tipping point that offers retinoic acid resistance.

There are details of the structure of the living cell, essential features in the composition of metals, cotton, silk, rubber, paint, bone, nerve, and a thousand other things which are hidden even from the microscope, and must always remain so hidden because the failure does not lie with the skill of the optician but with the incapacity of light itself.

Cancer stem - like cells are thought to be the root cause of chemotherapy resistance, leading to treatment failure in patients with advanced disease and the triggers of tumour recurrence and metastasis (regrowth).

One company, Melbourne, Australia — based Mesoblast, is already in late - stage clinical trials, treating hundreds of chronic heart failure patients with stem cell precursors drawn from healthy donors» hip bones.

Cultures representing two other hereditary liver diseases, alpha 1 — antitrypsin deficiency (a protein - folding disorder that leads to cell death and liver failure) and glycogen storage disease, type 1a (in which a liver enzyme deficiency impairs the body's glucose metabolism), also displayed disorder - specific abnormalities.

Mesoblast's earlier - stage trials, published in 2015 in Circulation Research, found that patients who received injections of its cell mixture had no further problems related to heart failure.

Failure of an enzyme to break down DNA spilling into the bloodstream as cells die may be a major driver of inflammation in lupus.

They will have to address side effects such as the flulike symptoms and the kidney failure that occurred in one patient due to all the dead cells the body had to cleanse from the blood.

The stories had described in detail how Moriguchi and colleagues injected induced pluripotent stem (iPS) cells into six patients with serious heart failure.

She is one of 16 patients in the first U.S. trial using cells extracted from adult bone marrow to reverse advanced heart failure.

And in 2010, a 46 - year - old woman developed multiple tumours in her kidney after having her own bone marrow stem cells injected at a private clinic in an attempt to treat her kidney failure.

Additional studies will follow to validate the value of stem cell - based regenerative solutions in addressing abnormal cardiac motion in heart failure, ultimately leading to improved patient care.

Tufts Medical Center and Tufts University scientists have found exciting, new functions of the protein angiogenin (ANG) that play a significant role in the regulation of blood cell formation, important in bone marrow transplantation and recovery from radiation - induced bone marrow failure.

In March last year, the FDA approved Perin's request to conduct the country's first advanced, randomized, double - blind clinical trial of stem cells for heart failure.

«These studies,» Shyam Bansal, Ph.D., Sumanth Prabhu, M.D., and colleagues write in the journal Circulation: Heart Failure, «provide important proof - of - concept for T - cells as disease mediators in heart failure.Failure, «provide important proof - of - concept for T - cells as disease mediators in heart failure.failure.»

Memory cells are why vaccination is effective; however, in the case of heart failure, memory cells may be responsible for an ongoing capacity of T - cells to injure the heart.

In Remodeling of the Mononuclear Phagocyte Network Underlies Chronic Inflammation and Disease Progression in Heart Failure: Critical Importance of the Cardiosplenic Axis, Prabhu and colleagues showed that immune cells that are stored in the spleen were intricately involved in the heart failure that follows a heart attack, or infarction, in a mouse - model systeIn Remodeling of the Mononuclear Phagocyte Network Underlies Chronic Inflammation and Disease Progression in Heart Failure: Critical Importance of the Cardiosplenic Axis, Prabhu and colleagues showed that immune cells that are stored in the spleen were intricately involved in the heart failure that follows a heart attack, or infarction, in a mouse - model systein Heart Failure: Critical Importance of the Cardiosplenic Axis, Prabhu and colleagues showed that immune cells that are stored in the spleen were intricately involved in the heart failure that follows a heart attack, or infarction, in a mouse - model Failure: Critical Importance of the Cardiosplenic Axis, Prabhu and colleagues showed that immune cells that are stored in the spleen were intricately involved in the heart failure that follows a heart attack, or infarction, in a mouse - model systein the spleen were intricately involved in the heart failure that follows a heart attack, or infarction, in a mouse - model systein the heart failure that follows a heart attack, or infarction, in a mouse - model failure that follows a heart attack, or infarction, in a mouse - model systein a mouse - model system.

These misshapen cells get stuck in blood vessels, causing blockages, anemia, pain, organ failure and significantly shortened lifespan.

«Contrary to previous studies, diabetes affects diaphragm, smooth muscle cells differently: Discovery could lead to better research of respiratory failure in individuals with diabetes.»

Nonalcoholic fatty liver disease — NAFLD — is a build up of fat in liver cells that disrupts liver function and, if left untreated, can lead to liver failure.

They found the CD4 + T - cells were globally expanded and activated during chronic ischemic heart failure, and that there was an expansion of memory T - cells in the spleen.

«Virtual tissue technology reveals new drug target in polycystic kidney disease: Advanced computer simulations show that failures of cell adhesion and inhibition cause two types of kidney cyst formation.»

If the study holds up and some miscarriages are in fact due to failure of the fetal cells to produce enough IDO, then drugs might be developed that mimic the enzyme's T cell - dampening effects.

«What many developmental diseases have in common seems to be the failure of brain cells to mature at the same rate as they do in healthy people,» says Dr Falk.

Previous examples were the conviction of Italian researchers for their failure to warn about the risk of a deadly earthquake in L'Aquila and the recent debate about the Stamina Foundation, which offers stem cell therapies that many scientists say aren't scientifically proven.

«You want the cells to get activated but you don't want them to stay activated for too long,» says neurobiologist Katerina Akassoglou of the University of California, San Diego, because the fibers begin substituting for healthy liver tissue, leading to liver failure in people with chronic cirrhosis, for example.

«We think that by stopping fibrosis through TAZ and its partners, we may be able to prevent the serious consequences of NASH, including liver failure and liver cancer,» said Ira Tabas, Richard J. Stock Professor and vice-chair of research in the Department of Medicine and professor of pathology & cell biology (in physiology and cellular biophysics) at CUMC.

They found that reducing the level of VEGF - A in mouse kidney cells caused kidney failure very similar to that seen in women suffering from preeclampsia.

Scientists at Columbia University Medical Center (CUMC) have identified a factor in liver cells that is responsible for turning a relatively benign liver condition, present in 30 percent of U.S. adults, into a serious disease that can lead to liver failure.

Mitochondrial diseases affect the batteries of the cell and can lead to muscular weakness, blindness, fatal heart failure, learning disability, liver failure, diabetes and can lead to death in early infancy.

Unlike most other cells in the human body, heart cells do not have the ability to self - repair or regenerate effectively, making heart attack and heart failure severe and debilitating.

But in patients with type 1 diabetes, beta - cell replacement therapy is likely doomed to failure because the new cells might fall victim to the same autoimmunity that destroyed the original cells.

«Key protein drives «power plants» that fuel cells in heart, other key body systems: Discovery explains KLF4, mitochondrial connection in heart failure.»

Tests in mice and nonhuman primates had shown TGN1412 to be safe, but when it was injected into humans — in a dose less than 1/500 of what was given to monkeys — it caused a massive release of infection - fighting T cells that overstimulated the patients» immune systems, resulting in multiple organ failure.

In the strongest test of their potential yet, six people with heart failure will be treated in France with a patch of immature heart cells made from hESCs, and 40 people with diabetes in the US will receive pouches containing immature pancreas cells made from hESCIn the strongest test of their potential yet, six people with heart failure will be treated in France with a patch of immature heart cells made from hESCs, and 40 people with diabetes in the US will receive pouches containing immature pancreas cells made from hESCin France with a patch of immature heart cells made from hESCs, and 40 people with diabetes in the US will receive pouches containing immature pancreas cells made from hESCin the US will receive pouches containing immature pancreas cells made from hESCs.

Using specimens collected annually in patients seen at Dr. Young's bone marrow failure clinic at the NIH Clinical Center, the investigators show that patients can support good blood cell production for many years from only a few stem cell clones, which can contain many unfavorable mutations.