Sentences with phrase «cell fate changes»
Our working hypothesis is that the signalling module we have uncovered underlies the coupling cell fate changes to EMT in a variety of developmental and pathological processes.
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In contrast to the conversion of alpha cells, which only concerns a small fraction of the alpha cell population, the new mechanism involving delta cell fate change is a more efficient way of offsetting the loss of beta cells and thus diabetes recovery.
Not exact matches
Although transcription factors are often the ingredients scientists use to induce stem cell fate, Dalby and Ulijn hypothesize that certain metabolites «fuel» the pathways that result in variable concentrations of transcription factors that drive these changes.
«It's a change in cell fate, back to neural crest status.»
«But our work shows it's possible to change the fate of scar - forming cells in the heart, and this could potentially benefit people who have heart attacks,» Ubil said.
«What changes a cell, or what regulates a cell to follow certain cell fate decisions?
If so, it could make cell fate more resilient to random mutations in a plant's genetic code, even when such changes keep some gene - regulating proteins from binding their intended DNA targets.
He studies how structural changes to chromosomes impact gene expression and cell fate with a focus telomere, telomerase, and chromosomal stability, epigenetic proteins, and the role of the SOSS complex in DNA damage repair.
Decades of research have shown that differentiation is the result of stereotypic gene expression changes that are required to specify the fate of a cell.
We focus on how changes in chromatin structure orchestrate the developmental transitions from fertilization to genome activation to cell fate specification.
By determining how changes in gene expression affect the fate of glial cells in mice, we hope to understand the key factors that govern neural cell regeneration in the human brain.
Aberrant regulation of the epigenetic information results in changes in cell fate decisions, thereby affecting development and tissue homeostasis, and ultimately leading to disease, such as cancer.
«These two studies really show that if you just manipulate intercellular signaling pathways, cell fate can be changed,» said Chun - Li Zhang, a neuroscientist at the University of Texas Southwestern Medical Center, who did not participate in the research.
1) It is essential to determine the fate of the missing endodermal cells: is there a change in proliferation or cell death?