Sentences with phrase «cell fate decisions»

Particularly, he is interested in the analysis of stem cell fate decisions and of individual stem cell clone dynamics.

The study sought to test whether the surface alone, absent any added soluble factors to influence cell fate decisions, can have an effect on differentiation.

Another view is that tumors can become resistant to therapy by a process called cell fate decision, by which some tumor cells are killed by therapy and others become cancer stem cells.

How cells in the embryo coordinate epithelial plasticity with cell fate decision in a fast changing cellular environment is largely unknown.

In the paper, JAX Professor Martin Pera, Ph.D., and Assistant Professor Christopher Baker, Ph.D., note that more refined knowledge of the differences between pluripotent and totipotent stem cells is needed, particularly the molecular regulatory networks that govern cell fate decisions in early mammalian development.

Her goals are to continue working to understand how the dynamics of p53 and other signaling pathways important in cancer control cell fate decisions.

A two - step process appears to regulate cell fate decisions for many types of developing cells, according to researchers from the University of Chicago.

The target of the new drug is an enzyme in cancer stem cells and tumor cells called Polo - like kinase 4, which was selected because blocking it negatively affects cell fate decisions associated with cancer stem cell renewal and tumor cell growth, thus stopping tumor growth.

«What changes a cell, or what regulates a cell to follow certain cell fate decisions?

«What is quite amazing is that manipulating just a single microRNA was able to greatly expand cell fate decisions of embryonic stem cells,» He said.

These experimental systems allow scientists to dissect key molecular pathways that specify cell fate decisions in embryonic development,» said team leader Lin He, a UC Berkeley associate professor of molecular and cell biology.

The Hippo pathway not only defines final tissue size by controlling developmental growth, but is also key to specifying stem cell identity and proliferation, to regeneration and tissue repair, as well as numerous cell fate decisions.

They study the mechanism of genome organization in development, homeostasis — metabolic balance — and aging; and the influence of cell morphogenesis, or cell shape and steructure, on cell fate decisions.

This is a significant discovery: in many cellular contexts, essential cell fate decisions are associated with an EMT.

Inhibiting EMT arrests cell fate decision in these experimental models, suggesting a mechanistic link between both processes that has never been understood.

He is interested in the molecular control of stem and progenitor cell fate decisions.

Chairs: Jozef Dulak, Jagiellonian University and Shahin Rafii, Weill Cornell Medical College Karen K. Hirschi, Yale School of Medicine Role of vascular endothelial cells in stem cell generation and maintenance Ann Zovein, University of California, San Francisco Cell fate decisions in hemogenic endothelium (Stem Cells I under Cells and Vascular Beds)

GLS - 1, a novel P granule component, modulates a network of conserved RNA regulators to influence germ cell fate decisions.

The lab will be focused on the identification of cellular and molecular events regulating hematopoietic cell fate decisions with emphasis on DC development.

These modifications of p53 are believed to fine tune p53 - dependent gene regulation and cell fate decisions by affecting p53 protein stability, DNA binding affinity and interactions between p53 and other transcription cofactors.

Professor Sten Eirik Jacobsen is head of the research program which is focused on identifying molecular mechanisms governing stem cell fate decisions, and lineage development within the hematopoietic system.

«Though many issues remain unresolved,» Pera and Baker write, «the emerging field of totipotent stem cell culture is already helping to illuminate the molecular regulatory networks that govern cell fate decisions in early mammalian development, and is liable to empower our efforts to exploit stem cells in animal biotechnology and medicine in the future.»

«In the cell, noise is constantly «jiggling the handle» that controls cell fate decisions, and this causes some cells — randomly — to switch fates,» he said.

miRNAs function as important regulatory switches, influencing cell fate decisions and tumor development.

Dr Mohammed at the Babraham Institute, said: «Our analyses suggest that elevated transcriptional noise at two key points in early development coincides with cell fate decisions.

«It suggests to us that targeting the pathways used in regulating cell fate decisions — how stem cells choose between cell proliferation and differentiation — could be a more effective way of halting tumours in their tracks and lead to potential new therapies.»

Genome architecture's surprising role in cell fate decisions (15/01/2018) New study led by researchers at the Centre for Genomic Regulation (CRG) in Barcelona, Spain, shows unexpected and crucial role of genome architecture in determining cell fate.

According to Ihor Lemischka, director of the Black Family Stem Cell Institute at Mount Sinai in New York City, this is one of the first computational models of stem cell fate decisions.

His current work deploys post-genomic technologies and mathematical modeling approaches to gain further insight into how blood stem cells are configured in molecular terms, the nature of the pathways involved in their cell fate decisions, and how these are corrupted by chimaeric transcription factors associated with human leukaemia.

Her group is particularly interested in the cellular and molecular mechanisms which control lung epithelial stem cell fate decisions.

Discussion themes included: - stem cell heterogeneity - stem cell fate decisions - stem cells in regeneration & development - stem cells in disease & treatment - stem cell related bioengineering & biomaterial - theoretical stem cell biology - mathematical modelling with a focus (but no restriction) on neural stem cells, hematopoietic stem cells and diabetes.

Found that muscle - specific histone methyltransferases and microRNAs regulate the activity of Hand2, a transcription factor essential for ventricle formation and more recently showed that microRNAs can efficiently guide stem cell fate decisions.

Proteolysis in Cell Cycle and Cell Fate Decisions: How Ubiquitylation Coordinates Proliferation and Differentiation

Aberrant regulation of the epigenetic information results in changes in cell fate decisions, thereby affecting development and tissue homeostasis, and ultimately leading to disease, such as cancer.

It is involved in the establishment of cell asymmetry, is particularly evident in large cells, such as eggs and neurons, and has key roles in cell fate decisions, cell migration, cell morphology, and polarised cell functions.