We are studying the mechanisms that maintain multipotent
cell fate during quiescence (reversible cell cycle arrest) using C. elegans as a model for aging stem cells.
Differentially activated macrophages orchestrate myogenic precursor
cell fate during human skeletal muscle regeneration
With our unique robotic microscope technology, can we identify the major determinants of
cell fate during normal development of stem cells and in neurodegenerative disease?
Martin Kragl (Tanaka, MPG)-- «Studying the patterning mechanisms and
cell fates during limb regeneration in Ambystoma mexicanum» (2007)
Not exact matches
The search for answers might shed light on how
cells»
fates become fixed
during development, and how plants manage to retain such flexibility.
In a similar way to how they work in other
cells, epigenetic markers push PGCs to their
fate during embryonic development, but PGCs are unique because when they develop into sperm and eggs, the epigenetic markers are erased.
It involves the way an egg
cell is built and how information positioned
during that construction affects the
fate of the embryo.
Another provocative observation from the new study was that transient gene expression events
during brain development set up broad distinctions in neural
fate between
cells in different areas in the cerebral cortex.
Abstract
During muscle regeneration, the conversion of muscle stem
cells to terminally differentiated myofibers requires multiple
cell fate transitions.
Asymmetric Localization of < i > Cdx2 mRNA
during the First
Cell -
Fate Decision in Early Mouse Development.
The project will focus on answering the question, how an embryonic stem
cell computes cues from its environment to elicit a regulated, exact
cell fate choice
during a process called «differentiation».
While TSCs give rise to the placenta, these stem
cells establish their identity long before the placenta develops; their
fate is determined
during the early embryo.
The regulation of transcription
during the transitions from fertilization to genome activation to
cell fate specification is a critical developmental process, yet it is poorly understood.
The sorting out of
cells with different identities and
fates during animal development is an important process to organize functional tissues and organs.
First, we find that microRNA activity is modulated
during dauer in order to regulate
cell fate.
The single -
cell perspective has helped to better understand gene regulation and regulatory networks
during exit from pluripotency,
cell -
fate determination as well as molecular mechanisms driving cellular reprogramming of somatic
cells to induced pluripotent stage.