Sentences with phrase «cell fate from»

Demonstrated that not a single «master» transcription factor, but rather a combination of factors, are important for reprogramming of cell fate from one somatic lineage back to a pluripotent state.

Research Interests: Molecular control of cell fate from stemness to differentiated skeletal and neuronal cell types; SOX transcription factors; skeletal malformation and degeneration diseases; intellectual disability and autism spectrum disorders; mouse genetic models; human pluripotent stem cell differentiation models in vitro

Not exact matches

Researchers from the Department of Biomedicine at the University of Basel have now found that the fate of adult hippocampal stem cells is not only controlled by their local niche, but also by a cell - intrinsic mechanism.

Now, in a new study published today, Sept. 8, in the Proceedings of the National Academy of Sciences, a team of researchers from the University of Wisconsin - Madison has added a new wrinkle to the cell differentiation equation, showing that the stiffness of the surfaces on which stem cells are grown can exert a profound influence on cell fate.

Using fluorescent labels, they were able to track the fates of marked and unmarked chromosomes under the microscope, from egg cells and sperm to the dividing cells of embryos after fertilization.

Following genetic instructions and taking cues from its environment, each cell realizes its fate — a fate that is inextricably linked to our own.

Every cell in the body uses phosphorylation, the process of adding a chemical tag to control a protein's function and fate, such as when it moves from one part of a cell to another or binds to other proteins.

If so, it could make cell fate more resilient to random mutations in a plant's genetic code, even when such changes keep some gene - regulating proteins from binding their intended DNA targets.

Another provocative observation from the new study was that transient gene expression events during brain development set up broad distinctions in neural fate between cells in different areas in the cerebral cortex.

From directing the fate of stem cells to determining how tall we grow, the genes in our body act in complex networks.

The quickest, most efficient way to micromanage the cells» developmental decisions was to apply a simultaneous combination of factors that both encouraged the differentiation into one lineage while also actively blocking the cells from a different fate — a kind of «yes» and «no» strategy.

Cell therapy, as envisaged by the teams of I - Stem, is primarily based on the identification of experimental protocols that can specifically guide differentiation of pluripotent cells to a cell fate, which presents a interest for the replacement of the defective cell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, etCell therapy, as envisaged by the teams of I - Stem, is primarily based on the identification of experimental protocols that can specifically guide differentiation of pluripotent cells to a cell fate, which presents a interest for the replacement of the defective cell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, etcell fate, which presents a interest for the replacement of the defective cell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, etcell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, etc.).

A two - step process appears to regulate cell fate decisions for many types of developing cells, according to researchers from the University of Chicago.

HTT modulates mitotic spindle orientation and cell fate in mouse cortical progenitors from the ventricular zone.

Understanding how organisms grow from one cell type to many different cell types is the overall goal of lineage tracing or fate mapping experiments, the first of which date to the late 19th century.

We have developed a technology for visualizing the behavior of DNA molecules within living cells, and elucidated the intracellular fate of DNA introduced from the outside.

«Finally, to assess the potential fate of mtDNA under condition when the cells can replicate extensively (longer than allowed by UK law), they derived human embryonic stem cell (hESC) lines from five ePNT blastocysts.

The project will focus on answering the question, how an embryonic stem cell computes cues from its environment to elicit a regulated, exact cell fate choice during a process called «differentiation».

We focus on how changes in chromatin structure orchestrate the developmental transitions from fertilization to genome activation to cell fate specification.

Dr Véronique Azuara has worked for several years in the field of developmental biology and genetics moving from lymphocyte development (PhD training at the Pasteur Institute — Paris) to epigenetic studies (post-doctoral training at the MRC / Clinical Sciences Centre — London) to explore how chromatin shut down contributes to lineage restriction and maintenance of cell fate identity through development.

The regulation of transcription during the transitions from fertilization to genome activation to cell fate specification is a critical developmental process, yet it is poorly understood.

In collaboration with experimental groups we use methods from statistical physics to study mechanisms of cell fate regulation in tissue development, maintenance and disease.

May 25, 2000 Different levels of transcription factor coax immune cell progenitors down different developmental pathways Researchers from the University of Chicago provide evidence that varying levels of a single transcription factor can determine the fates of developing cells.

In a paper published in Nature Genetics, an interdisciplinary research team of scientists from the Centre for Genomic Regulation (CRG)-- including a Centro Nacional de Análisis Genómico (CNAG - CRG) group — in Barcelona, Spain, shows that the three - dimensional organisation of the genome plays a key role in gene expression and consequently in determining cell fate.

Both human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC) can colonize the mouse embryo in a manner predicted from classical developmental fate mapping and faithfully recapitulate tissue - specific fate post-transplantation.

Our cells have built - in programming that sometimes veers them far away from their normal fate.

The research, described in the journal Stem Cells under the title «Reprogramming Postnatal Human Epidermal Keratinocytes Toward Functional Neural Crest Fates,» was supported by grants from the National Institutes of Health.

Kelly earned her Ph.D. in Cell and Molecular Biology from the University of Pennsylvania studying the role of the EGF - Ras - ERK signaling pathway in cell fate specificatCell and Molecular Biology from the University of Pennsylvania studying the role of the EGF - Ras - ERK signaling pathway in cell fate specificatcell fate specification.

The single - cell perspective has helped to better understand gene regulation and regulatory networks during exit from pluripotency, cell - fate determination as well as molecular mechanisms driving cellular reprogramming of somatic cells to induced pluripotent stage.

Cross posted from Spoonful of Medicine The US Patent and Trademark Office granted its first license related to induced pluripotent stem (iPS) cells to a California biotech, Fate Therapeutics, the company announced today.

OPENING THIS WEEK Kam's Kapsules: Weekly Previews That Make Choosing a Film Fun by Kam Williams For movies opening January 4, 2008 BIG BUDGET FILMS One Missed Call (PG - 13 for mature themes, frightening images, terror, intense violence and some sexual material) Shannyn Sossamon stars in this remake of Chakushin Ari, a high attrition - rate horror flick from Japan about a traumatized young woman who's afraid to answer her cell phone after several of her ill - fated friends receive messages accurately predicting exactly when and how they are about to die.

Worse, who knows what rat - infested prison cell fate I might have faced had police descended upon the hut in which I was sleeping in Thailand's golden triangle when only a few feet away from me a few of my fellow trekkers smoked local opium?