Sentences with phrase «cell fate in»

We have shown that p53 and Notch inhibiting mutations, both of which are common in squamous cancers, imbalance cell fate in this way, generating large mutant clones.

Our current works have focused on screening the chemical libraries to identify and further characterize small molecules that can control stem cell fate in various systems.

HTT modulates mitotic spindle orientation and cell fate in mouse cortical progenitors from the ventricular zone.

«We see elements of this framework of primary and secondary cell - fate determinants throughout the hematopoietic system,» said study author Harinder Singh, the Louis Block Professor of Molecular Genetics & Cell Biology and a Howard Hughes Medical Institute Investigator at the University of Chicago, «and we suspect such networks also regulate cell fate in other systems.»

«In addition to advancing our understanding of human embryonic development, the findings suggest we may be able to use metabolites, relatively simple compounds, to alter cell fate in the treatment of common disorders.»

«Sniffing out stem cell fates in the nose: Using single - cell RNA sequencing and clever statistical analysis to track stem cells as they mature.»

Genetic approaches in mouse model systems combined with cell biological assays have allowed Professor Lukas Sommer to identify mechanisms regulating stem cell fates in the developing CNS and in neural crest - derived tissues.

Our findings suggest that pluripotency is determined by the capacity of a mixed population of lineage - biased intermediates to commit to different cell fates in specific contexts.

Not exact matches

The event will be headlined by a world title match between Triple H and Roman Reigns, as well as a Hell in a Cell match between Undertaker and Shane McMahon, with the fate of WWE hanging in the balance.

Molecular characterization of the cells that undergo cell fate transition upon oncogenic Pik3ca expression demonstrated a profound oncogene - induced reprogramming of these newly formed cells and identified gene expression signatures, characteristic of the different cell fate switches, which was predictive of the cancer cell of origin, tumour type and clinical outcomes in women with breast cancers.

Now, in a new study published today, Sept. 8, in the Proceedings of the National Academy of Sciences, a team of researchers from the University of Wisconsin - Madison has added a new wrinkle to the cell differentiation equation, showing that the stiffness of the surfaces on which stem cells are grown can exert a profound influence on cell fate.

In contrast to the conversion of alpha cells, which only concerns a small fraction of the alpha cell population, the new mechanism involving delta cell fate change is a more efficient way of offsetting the loss of beta cells and thus diabetes recovery.

The findings — published today in Nature — provide significant insights into cell types fated to relapse and can help accelerate the quest for new, upfront therapies, says Dr. Dick, a Senior Scientist at Princess Margaret Cancer Centre, University Health Network, and Professor in the Department of Molecular Genetics, University of Toronto.

The two - part approach netted a set of mutations seen only at relapse that enabled the team to sift and sort leukemic and normal stem cells using tools developed in the Dick lab a few years ago to zero in on specific cell types fated to relapse.

It will be relatively easy for the team to monitor the fate of the new cells because they can be seen in the eye through a microscope.

Although transcription factors are often the ingredients scientists use to induce stem cell fate, Dalby and Ulijn hypothesize that certain metabolites «fuel» the pathways that result in variable concentrations of transcription factors that drive these changes.

They discovered novel mechanisms in cells with the ability to activate pathways that crosstalk one to another and then assemble consolidated responses that decide cell fate.

In a similar way to how they work in other cells, epigenetic markers push PGCs to their fate during embryonic development, but PGCs are unique because when they develop into sperm and eggs, the epigenetic markers are eraseIn a similar way to how they work in other cells, epigenetic markers push PGCs to their fate during embryonic development, but PGCs are unique because when they develop into sperm and eggs, the epigenetic markers are erasein other cells, epigenetic markers push PGCs to their fate during embryonic development, but PGCs are unique because when they develop into sperm and eggs, the epigenetic markers are erased.

Around 2000, then - postdoc Wagers and other researchers in Irving Weissman's and Thomas Rando's labs at Stanford revived the method, known as parabiosis, to study the fate of blood stem cells and muscle cells.

This is interesting because it implies that all the instructive mechanisms [for these cells» fate] are present in the adult brain.»

In addition, it provides a marker for cell fates and insight into the molecular and cellular mechanisms by which FSC progeny diverge into distinct fates.

Fate «is counting on this patent to raise funding, so they will be relentless» in pushing their claims, says stem cell researcher Jeanne Loring of the Scripps Research Institute in San Diego.

Her research team placed the evolutionarily conserved castor (Cas) gene, which encodes a zinc finger protein, in a genetic circuit with two other evolutionarily conserved genes, hedgehog (Hh) and eyes absent (Eya), to determine the fates of specific cell progeny (daughters).

The article «EGFR signalling controls cellular fate and pancreatic organogenesis by regulating apicobasal polarity» has been published in Nature Cell Biology.

«It's a change in cell fate, back to neural crest status.»

Because the precise activation of Hox genes is essential for a cell's fate, «the research should prove extremely useful in developing novel embryonic stem cell - based therapies, Mazzoni adds.

Nishimura suspected that genotoxic stressors, such as radiation or harsh chemicals, might play a role in the stem cells» fate, because they've been implicated in other signs of aging.

After this initial color assignment, the color information was propagated in time using the tracking information, thus providing a color - coded single - cell resolution fate map.

«But our work shows it's possible to change the fate of scar - forming cells in the heart, and this could potentially benefit people who have heart attacks,» Ubil said.

Every cell in the body uses phosphorylation, the process of adding a chemical tag to control a protein's function and fate, such as when it moves from one part of a cell to another or binds to other proteins.

In work published this week in Cell, Tavazoie and his colleagues describe how fluctuations in the amount of tRNAs can have a dramatic impact not only on the fate of a single cell, but also on diseases like metastatic breast canceIn work published this week in Cell, Tavazoie and his colleagues describe how fluctuations in the amount of tRNAs can have a dramatic impact not only on the fate of a single cell, but also on diseases like metastatic breast cancein Cell, Tavazoie and his colleagues describe how fluctuations in the amount of tRNAs can have a dramatic impact not only on the fate of a single cell, but also on diseases like metastatic breast canCell, Tavazoie and his colleagues describe how fluctuations in the amount of tRNAs can have a dramatic impact not only on the fate of a single cell, but also on diseases like metastatic breast cancein the amount of tRNAs can have a dramatic impact not only on the fate of a single cell, but also on diseases like metastatic breast cancell, but also on diseases like metastatic breast cancer.

This study provides experimental evidence which shows the important role of RNA levels in the controlling the fate of embryonic stem cells, and shows an understanding of RNA's ability to differentiate stem cells at the molecular level.

The Eveland laboratory's research findings, «Brassinosteroids modulate meristem fate and differentiation of unique inflorescence morphology in Setaria viridis,» were recently published in the journal The Plant Cell.

Germ cells, irrespective of the sexual fate (to become sperm or eggs), have the potential to feminize the body in medaka.

In their latest study, they generated three different medaka mutants to demonstrate that the feminizing effect of germ cells is not a result of the progression of gametogenesis or a sexual fate decision of germ cells.

If so, it could make cell fate more resilient to random mutations in a plant's genetic code, even when such changes keep some gene - regulating proteins from binding their intended DNA targets.

In that case, the genetic information within the chromosome copies remains the same, but the type of cell, or «cell fate,» is different.

Each ended up taking on the characteristics of its new neighbors, implying that the environment that they grew up in strongly influenced the fate of these cells.

Researchers have identified a set of DNA - binding proteins in the roots of the plant Arabidopsis thaliana that work in combination to help precursor cells selectively read different parts of the same genetic script and acquire their different fates.

At the GSA Drosophila Research Conference, TinTin Su, Ph.D., will report that a dying Drosophila melanogaster larvae cell alerts neighboring cells that they are in danger of suffering a similar fate.

Using genetic methods to map the fate of the cells, the scientists could demonstrate that astrocytes in this area formed immature nerve cells, which then developed into mature nerve cells.

Using her new culture system, she joined forces with colleagues to research which cells in an embryo contribute to which parts of the adult animal, a process called fate - mapping.

This was, in a sense, a possible molecular answer to the hunch about early mammalian fates voiced by Arthur Hertig of the two - celled embryo half a century earlier.

Another provocative observation from the new study was that transient gene expression events during brain development set up broad distinctions in neural fate between cells in different areas in the cerebral cortex.

The images depict what might be called embryology in flagrante: micrographs of sperm cells, trailing accordion - like pleats of white zags as they streak across a vast blue ocean of ooplasm; a multihued blastocyst in the process of hatching out of the egg's zona pellucida; and egg cells with a fringe of glowing, fate - determining proteins, looking a bit like a solar eclipse inside a cell.

A print of that first micrograph of a two - celled human embryo is now framed and hangs on the wall above the desk in David Albertini's small, crowded office at Tufts University where, 30 years after he cleaned the monkey cages in Southborough, he conducts research trying to figure out how the fate of those two cells is determined.

But whether similar fates befell the vast majority of proteins in normal cells remained unclear.

Because of the consistency among many cells, they concluded that TCF - 1 control of T - cell fate is fundamentally important in determining what a cell will become.

Nonetheless, it has become increasingly clear that the fate of an embryo may be cast in the ovarian follicles, where egg cells are built.

In their experiments, about 20 percent of embryonic stem cells lacking the microRNA exhibited expanded fate potential.