Sentences with phrase «cell fate regulation»

In collaboration with experimental groups we use methods from statistical physics to study mechanisms of cell fate regulation in tissue development, maintenance and disease.

The question of how cellular behavior is controlled is at the center of stem cell biology, and understanding the mechanisms of cell fate regulation is key for treating diseases that occur upon dysregulation, such as cancer or diabetes.

Not exact matches

Hypoxia - mediated regulation of stem cell fate.

In studying the regulation of gene dosage, his lab described the first known biological role of a microRNA in the mammalian system, ultimately revealing a network of microRNAs that titrate the dose of key cardiac gene networks that dictate cell fate and differentiation.

Critical issues include: (i) heterogeneity in stem cell populations (ii) regulation of cell fate choices; (iii) declining tissue performance with age and exposure to environmental injuries; (iv) the use of iPS and Embryonic Stem (ES) cells, and reprogramming methods for phenotyping disease states and potential use of these stem cells in the clinic.

The regulation of transcription during the transitions from fertilization to genome activation to cell fate specification is a critical developmental process, yet it is poorly understood.

In a paper published in Nature Genetics, an interdisciplinary research team of scientists from the Centre for Genomic Regulation (CRG)-- including a Centro Nacional de Análisis Genómico (CNAG - CRG) group — in Barcelona, Spain, shows that the three - dimensional organisation of the genome plays a key role in gene expression and consequently in determining cell fate.

These modifications of p53 are believed to fine tune p53 - dependent gene regulation and cell fate decisions by affecting p53 protein stability, DNA binding affinity and interactions between p53 and other transcription cofactors.

Aberrant regulation of the epigenetic information results in changes in cell fate decisions, thereby affecting development and tissue homeostasis, and ultimately leading to disease, such as cancer.

The single - cell perspective has helped to better understand gene regulation and regulatory networks during exit from pluripotency, cell - fate determination as well as molecular mechanisms driving cellular reprogramming of somatic cells to induced pluripotent stage.

Dr. Ivey's research focuses on the regulation of cardiac - cell fates.