Sentences with phrase «cell fate switching»
Molecular characterization of the cells that undergo cell fate transition upon oncogenic Pik3ca expression demonstrated a profound oncogene - induced reprogramming of these newly formed cells and identified gene expression signatures, characteristic of the different cell fate switches, which was predictive of the cancer cell of origin, tumour type and clinical outcomes in women with breast cancers.
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A better understanding of this master switch regulator may help to understand, how cells that have a common origin take on a specific fate in the body to build an organ and may also help to understand the development of certain leukemias.
«In the cell, noise is constantly «jiggling the handle» that controls cell fate decisions, and this causes some cells — randomly — to switch fates,» he said.
When BMP turns ES cells into muscle it activates a protein called Smad1, a DNA - binding protein that, in opposition to Nanog, switches on genes responsible for muscle cell fate.
Notch activity is antagonised by the cell fate determinant Numb, which asymmetrically partitions at mitosis and «switches off» Notch signalling in one of the daughter cells (7).
miRNAs function as important regulatory switches, influencing cell fate decisions and tumor development.