Sentences with phrase «cell fate with»

He studies how structural changes to chromosomes impact gene expression and cell fate with a focus telomere, telomerase, and chromosomal stability, epigenetic proteins, and the role of the SOSS complex in DNA damage repair.

Not exact matches

The event will be headlined by a world title match between Triple H and Roman Reigns, as well as a Hell in a Cell match between Undertaker and Shane McMahon, with the fate of WWE hanging in the balance.

Molecular characterization of the cells that undergo cell fate transition upon oncogenic Pik3ca expression demonstrated a profound oncogene - induced reprogramming of these newly formed cells and identified gene expression signatures, characteristic of the different cell fate switches, which was predictive of the cancer cell of origin, tumour type and clinical outcomes in women with breast cancers.

They discovered novel mechanisms in cells with the ability to activate pathways that crosstalk one to another and then assemble consolidated responses that decide cell fate.

Her research team placed the evolutionarily conserved castor (Cas) gene, which encodes a zinc finger protein, in a genetic circuit with two other evolutionarily conserved genes, hedgehog (Hh) and eyes absent (Eya), to determine the fates of specific cell progeny (daughters).

Shah's stem cells escape this fate because they are made with a mutation that doesn't allow the toxin to act inside the cell.

«It was once believed that effector and memory cells arose as two distinct populations, with some cells initially fated to be effector type and some to be memory,» McDonald said.

Using her new culture system, she joined forces with colleagues to research which cells in an embryo contribute to which parts of the adult animal, a process called fate - mapping.

The images depict what might be called embryology in flagrante: micrographs of sperm cells, trailing accordion - like pleats of white zags as they streak across a vast blue ocean of ooplasm; a multihued blastocyst in the process of hatching out of the egg's zona pellucida; and egg cells with a fringe of glowing, fate - determining proteins, looking a bit like a solar eclipse inside a cell.

An asymmetric cell division in non-stem cells can instead result in two daughter cells with very different fates, such as one large cell that reinitiates cell division prematurely and a much smaller cell that either grows very slowly or dies.

The genetic and environmental cues that determine the cell's fate can be thought of as inputs, with the cell itself as the processor, Dunn says.

COURTESY SHENDURE AND SCHIER LABS CRISPR FOR FATE - MAPPING Researcher: Jay Shendure, Professor, Department of Genome Sciences, University of Washington Project: In collaboration with Alexander Schier's lab at Harvard University, Shendure's group came up with a new way to trace cell lineages in cell culture and in whole organisms — in this case, developing zebrafish.

Dietmar J. Kappes discovers a mouse with a mutation in a master regulator gene controlling T cell fate.

With our unique robotic microscope technology, can we identify the major determinants of cell fate during normal development of stem cells and in neurodegenerative disease?

FATE MAPPING WITH CRISPR: Thanks to a new tool called GESTALT, researchers can now introduce a 300 - base - pair lineage barcode into cells and, using the CRISPR - Cas9 system, allow edits to accumulate as those cells divide.

Discussion themes included: - stem cell heterogeneity - stem cell fate decisions - stem cells in regeneration & development - stem cells in disease & treatment - stem cell related bioengineering & biomaterial - theoretical stem cell biology - mathematical modelling with a focus (but no restriction) on neural stem cells, hematopoietic stem cells and diabetes.

Critical issues include: (i) heterogeneity in stem cell populations (ii) regulation of cell fate choices; (iii) declining tissue performance with age and exposure to environmental injuries; (iv) the use of iPS and Embryonic Stem (ES) cells, and reprogramming methods for phenotyping disease states and potential use of these stem cells in the clinic.

The sorting out of cells with different identities and fates during animal development is an important process to organize functional tissues and organs.

Genetic approaches in mouse model systems combined with cell biological assays have allowed Professor Lukas Sommer to identify mechanisms regulating stem cell fates in the developing CNS and in neural crest - derived tissues.

In collaboration with experimental groups we use methods from statistical physics to study mechanisms of cell fate regulation in tissue development, maintenance and disease.

I am a postdoctoral fellow with the Garner lab employing high - resolution microscopy in live bacteria and archaea towards the understanding of the cell cycle fate.

The lab will be focused on the identification of cellular and molecular events regulating hematopoietic cell fate decisions with emphasis on DC development.

In vertebrates, this segregation depends on canonical Wnt signaling, with β - catenin — positive cells preferentially adopting a paraxial fate and position (12).

Next, we identified genes whose expression was associated with Th1 or Tfh fates, and demonstrated a T - cell intrinsic role for Galectin - 1 in supporting a Th1 differentiation.

The new, US patent credits the Whitehead Institute's Rudolf Jaenisch, a scientific founder with Fate Therapeutics who licensed the technology to the company, and his former postdoc Konrad Hochedlinger, now at the Massachusetts General Hospital, with inventing a method for reprogramming cells

Eschewing the trappings of the biopic — psychology, cult of the hero — Assayas catches Carlos (Edgar Ramirez) mid-stream, between the fated year 1973 (Four Concepts of Psychoanalysis, coup in Chile), when Waddie Haddad (Ahmad Kaabour) makes him number two in the European network of the Popular Front for the Liberation of Palestine (PFLP); and 1994, when he is snatched in a Khartoum hospital by the French Secret Services who promptly brought him to stand trial in Paris: no cute or sinister growing - up tales, no face - to - face with oneself within the four walls of a cell.

We didn't want to turn on our cell phones because we were traveling internationally — and the trip was so short that it didn't make sense to get a local SIM card — so we spent the next two hours awaiting our fate, unsure if the security office would be able to get in touch with the apartment owner.