Sentences with phrase «cell from patients»

In the future, we would like to study skin cells from patients with disorders of motor neurons.

First, the researchers took skin cells from patients and introduced genes to correct the defective mutations.

He believes they may be able to get around this obstacle with advances in generating stem cells from patient cells that have already developed into a specific type of tissue, such as skin.

Both approaches, which involve merely adding a few chemicals to cells, could lead to new ways of treating disease by using cells from a patient's own body.

The researchers isolated tumor cells from patients and grew them to reproduce small tumors in the lab dish.

You's team removed immune cells from a patient with lung cancer.

More than 40 clinical trials are underway using other kinds of stem cells, mainly bone marrow cells from the patients themselves.

He says that it may soon be possible to take healthy liver cells from a patient whose liver is failing and use them to make tissue that would be stored in the laboratory.

Recently, scientists have engineered cells from a patient's own immune system to fight blood cancers.

This acts as a template on which to grow cells from the patient's body.

Scientists could build chips containing cells from patients with specific genetic mutations, which could predict drug responses in specific populations, as well as personalized chips that predict an individual's drug response.

The researchers first obtained the stem cells from patients via a muscle biopsy.

We can get new nerve cells from a patient's own eye.

Doctors could then collect blood or skin cells from a patient and turn them into healthy liver cells, enabling patients to be their own donors.

And other researchers question the need to use cells from the patient's own skin.

In contrast, PD - L1 blockade increased the capacity of Treg cells to multiply (and hence their overall numbers), but only in cells from patients with viremia, i.e. those that had detectable virus in their blood.

They began with clinical tissue samples obtained at autopsy from patients with lethal metastatic prostate cancer, then performed a range of sophisticated analyses to characterize the cancer cells from each patient in unprecedented detail.

In the March 22 online issue of Cancer Research, scientists explained how they injected triple negative breast cancer stem cells from patients into mice.

The team has already created or obtained iPS cells from patients with varying lengths of CAG expansion and from their unaffected family members.

Paul Insel, MD, professor of pharmacology and medicine, will investigate the expression of the GPCR family of receptors on the surface of cells from patients with chronic lymphocytic leukemia (CLL).

«We validated our findings in isolated blood cells from patients with sickle cell disease.»

The team is currently working on genome sequencing of individual circulating tumour cells from patients at the Vancouver Prostate Centre.

«In theory, we could model progression of the disease by reprogramming skin cells from patients at a range of ages, including before symptoms begin.

Daley and other scientists are using iPS technology to reprogram cells from patients with diseases such as Lou Gehrig's disease (amyotrophic lateral sclerosis), Huntington's disease, and diabetes.

According to his unpublished findings, when he puts glioblastoma cells from patients into lab dishes with brain organoids, the cells attach to the surface of the organoids, burrow into them, and within 24 to 48 hours grow into a mass that eventually «looks exactly like what happened in the patient's own brain,» Fine said.

They then examined the effect of a chemical that inhibits SRF and found that glucose uptake rates increased in both mice and human cells — and that the effects were greater in cells from patients who were insulin resistant or had type 2 diabetes.

For this study, Encode will isolate peripheral blood mononuclear cells from patients and generate gene expression profiles of cells through in vitro exposure to the candidate drug.

«It is exciting that they have generated human cells from the patient material,» says stem cell researcher Jeffrey Rothstein of Johns Hopkins University in Baltimore, Maryland, who also studies ALS.

Researchers have developed a new way to study bone disorders and bone growth, using stem cells from patients afflicted with a rare, genetic bone disease.

Biological and functional characterization of bone marrow - derived mesenchymal stromal cells from patients affected by primary immunodeficiency.

Dr. Olby wants to restore the myelin sheath to these surviving axons by taking fat cells from the patient and turning them into stem cells that can be combined with nerve cells and injected into the site of the damage, regrowing the sheath.

Mesenchymal stromal cells from patients with myelodyplastic syndrome display distinct functional alterations that are modulated by lenalidomide.

For many illnesses, researchers would like to study the diseased cells from a patient in the lab; their ultimate hope is that they can also fix those cells by modifying them genetically and then inject them back into the patient.

They found that a certain protein, known as S100B, is markedly increased in astroglial cells from patients with Down syndrome compared with those from healthy controls.

A low - oxygen environment — comparable to a vessel wall not receiving enough blood — caused cells from patients with a high angiogenesis score to make more than three times as much VEGF RNA.

When they sequenced the iPS cell lines, they found higher numbers of mitochondrial DNA mutations, particularly in cells from patients older than 60.

In cells from patients whose asthma did not respond well to treatment, researchers found a biochemical variation in the VNN - 1 molecular network that hindered its expression.

Labs could rejuvenate cells from patients and perhaps then grow them into new tissue that could repair parts worn out by old age or disease.

Researchers in Keele University's Research Institute for Science and Technology in Medicine and at the Haywood Rheumatology Centre, in Staffordshire, UK, and the University Hospitals of North Midlands NHS Trust, have for the first time identified disease - associated changes to the DNA epigenome in joint fluid cells from patients with rheumatoid arthritis.

Using this finding, researchers implemented a new way to use stem cells made from any individual, including cells from patients with cystic fibrosis, and turn them into airway cells, which they then grew into three - dimensional spheres.

In a collaborative effort between the Gladstone laboratories of Benoit Bruneau, PhD, Katherine Pollard, PhD, and Dr. Srivastava, the scientists used stem cell technology to make large amounts of endothelial cells from patients with CAVD, comparing them to healthy cells and mapping their genetic and epigenetic changes as they developed into valve cells.

In a new study published in Molecular Psychiatry the researchers describe how cells from patients with the severe developmental disease lissencephaly differ from healthy cells.

«Alzheimer's in a dish: Stem cells from patients offer model and drug - discovery platform for early onset form of disease.»

The group isolated cells from patient urine samples, amplified them, reprogrammed them into iPSCs and finally instructed them to become liver cells.

Salk scientists developed a new technique to grow aged brain cells from patients» skin.

Atala wondered whether it would instead be possible to remove bladder cells from a patient and use them to grow a replacement organ, thus eliminating the risk of transplant rejection.

The method, successfully tested in heart muscle cells from patients, offers an efficient alternative to the daunting task of developing an individualized molecular treatment for each gene mutation that causes DMD.

For the first time, researchers have been able to grow, in a lab, both normal and primary cancerous prostate cells from a patient, and then implant a million of the cancer cells into a mouse to track how the tumor progresses.

For this study, Yu, Hofmeister and their colleagues used cell lines and fresh myeloma cells from patients to produce genetically engineered T cells with a receptor that targets CS1.