The experimental test uses a plastic chip whose microscopic inner surfaces are covered in antibodies to grab
cancer cells from the blood.
The Porteus team started with human stem
cells from the blood of patients with sickle cell disease, corrected the gene mutation using CRISPR and then concentrated the human stem cells so that 90 percent carried the corrected sickle cell gene.
The chip would allow the filtering of cancer
cells from a blood sample, which would be an easier way to harvest cancer cells, rather than the current method of taking them from tumor sites in the body.
A team of physicians and laboratory scientists has taken a key step toward a cure for sickle cell disease, using CRISPR - Cas9 gene editing to fix the mutated gene responsible for the disease in
stem cells from the blood of affected patients.
To find out, they studied
T cells from blood samples from 71 children with dengue fever or dengue hemorrhagic fever.
Senior author Professor Karim Raza, also of the University of Birmingham, said: «Our findings were unexpected as we initially thought that cells from the inflamed rheumatoid joint would respond just as well to vitamin D
as cells from the blood.
Berkeley researchers isolated circulating
tumor cells from the blood of breast cancer patients, then used microscale physics to design a precision test for protein biomarkers, which are indicators of cancer.
They culled stemlike
cells from blood circulating through a patient's body and manipulated them into becoming red blood cells nearly identical to those that normally transport oxygen in the body.
Vortex's system uses a microfluidic chip to generate tiny vortices that trap larger, more deformable cancer
cells from a blood plasma sample.
Matthias Goebeler at the University of Giessen in Germany and his colleagues looked
at cells from the blood vessels of people with a nickel allergy.
The research demonstrated that following injury, there is increased migration of
inflammatory cells from blood to the liver, increasing IFNL3 secretion and liver damage.
The chip's key feature is a tiny flow channel on a hierarchically designed pad that is optimized to capture tumor
cells from the blood flowing across it.
They extracted white blood
cells from blood drawn from the animals during routine wellness checks and subjected the cells to treatments that damage DNA, a cancer trigger.
LA JOLLA, CA — For more than 20 years, doctors have been
using cells from blood that remains in the placenta and umbilical cord after childbirth to treat a variety of illnesses,...
When the oxygenated blood reaches your muscles the oxygen is absorbed into your
muscle cells from the blood capillaries that surround them.
A drop of blood is introduced into a thin glass tube and spun in a centrifuge to separate the red blood
cells from the blood serum or plasma.
Sarthak Laboratory (India) 2001 — 2003 Clinical Technologist • Cultured and identified aerobic organisms from blood, urine, stool, sputum, and other specimens • Detected human
lymphocytic cells from blood specimens • Directed and managed blood bank ensuring efficient and organized operations • Trained junior staff members providing assistance and guidance as needed
Dr. Christian Stemberger, first author of the study, and his colleagues, first isolated
T cells from the blood of healthy donor mice.
The vaccine is designed to work by extracting a patient's own
immune cells from blood and exposing them to a protein called prostatic acid phosphatase in the lab.
Professor Karim Raza, University of Birmingham, said, «Our findings were unexpected as we initially thought that cells from the inflamed rheumatoid joint would respond just as well to vitamin D
as cells from the blood.
Cedars - Sinai scientists can
harvest cells from the blood or skin of an individual and reprogram them into induced pluripotent stem cells, which can be made into any organ cell (such as those from the lung, liver or intestine), each bearing the unique genetic fingerprint and characteristics of the person.
Researchers expect that, in the long term, the method can also be used to identify the source of free
cancer cells from a blood sample, and thus also as an effective and easy way of monitoring people who are at risk of developing cancer.
Platelet - rich plasma is obtained via a process called centrifugation that removes red and white
blood cells from a blood sample while leaving behind a high concentration of platelets in the plasma.
In a different experiment, the scientists isolated cytotoxic T
cells from the blood of dengue - immune mice and infused them into normal mice, a procedure known as adoptive T - cell transfer.
Lu's team will extract immune cells called T
cells from the blood of the enrolled patients, and then use CRISPR — Cas9 technology — which pairs a molecular guide able to identify specific genetic sequences on a chromosome with an enzyme that can snip the chromosome at that spot — to knock out a gene in the cells.
In this way, they have managed to reproduce chromosomal translocations in human stem
cells from blood and mesenchymal tissue that are identical to those observed in patients with acute myeloid leukemia (a blood and bone marrow cancer) or Ewing's sarcoma (a type of bone tumour that affects children and teenagers).
The device has been used to separate different blood components, to separate cancer
cells from blood and to manipulate nanorod motors inside living cells, to name only a few research areas.
In this study, researchers measured the mtDNA amount and degree of mtDNA damage in blood
cells from blood samples from veterans with GWI.
So my field is science and technology, so my work is circulating tumor cells where I isolate cancer
cells from blood of patients and isolate their DNA and RNA and try to sequence them and try to device treatments for cancer treatment and therapy.
They measured the biological age of
cells from blood, saliva and inside the cheek, to explore the relationship between each woman's chronological age and her body's biological age.
«It occurred to me that there must be a way to obtain
the cells from the blood instead.»
Memorial Sloan Kettering Cancer Center's Dr. Howard Scher notes in the NCI piece that plucking the cancer
cells from blood is just the start.
UH researchers have identified a unique epigenetic footprint in specific types of immune
cells from blood that can identify individuals with HIV that have a range of impairments in cognitive function.
In a recent publication, we demonstrated that the human carbohydrate - binding protein galectin - 9 regulates HIV transcription and potently reactivates latent HIV in vitro, as well as ex vivo using CD4 + T
cells from the blood of HIV + individuals on suppressive antiretroviral therapy, in an N - glycan - dependent manner.
In essence, rather than trying to isolate and purify
these cells from a blood sample, HD - SCA captures the entire contents of a sample onto a specially treated glass slide.