Sentences with phrase «cell function within»

Buckwalter (1997) proposes that a gradual deterioration with age in the cell function within cartilage, ligaments, tendons and muscles is the mechanism for this loss of flexibility.

One cell function within this enzyme's jurisdiction is the detection of insulin by your glycogen stores.

Lycopene's effects on cancer cell functions within monolayer and spheroid cultures.

Emulate's Organ - Chips recreate the complex, dynamic state in which cells function within a human organ.

Not exact matches

Essentially the model reproduces the inner workings of all of the proteins within the organism and allows scientists to see everything from how cells interact with each other to the functions of genes in a larger context that had not been previously understood.

The benefits of flax seeds «chia «and milk thistle in this health supplement from HealthForce Nutritionals reportedly restricts the growth of harmful cells in your body «keeps blood glucose levels within a healthy range «and supports liver function.

Protein is essential for basic bodily functions; it helps to build new cells whilst looking after the tissues within your body (which lets face it, is pretty essential).

The fields within biology are further divided based on the scale at which organisms are studied and the methods used to study them: biochemistry examines the fundamental chemistry of life; molecular biology studies the complex interactions of systems of biological molecules; cellular biology examines the basic building block of all life, the cell; physiology examines the physical and chemical functions of the tissues and organ systems of an organism; and ecology examines how various organisms interrelate.

That was surprising, he explains, because «fibrillarin resides deep within the nucleolus of the host cell... [where it] methylates ribosomal RNA molecules, which then go on to form ribosomes,» but its full function may not be completely understood.

Because of their importance in cells, fatty acids» functions and metabolism, or breakdown have been widely studied by biologists, but the standard techniques makes it difficult to visualize precisely where these molecules are located within the cells.

To address this challenge, our research group is using nanoparticles not only to deliver more chemotherapy drugs to the target site within cancer cells, but also to compromise the function of the efflux pumps and thereby significantly improve safety and efficacy of cancer therapy.»

It has been particularly difficult to measure changes in electrical functions of cells grown within Organ Chips that are normally electrically active, such as neuronal cells in the brain or beating heart cells, both during their differentiation and in response to drugs.

As it can take weeks to grow human cells into intact differentiated and functional tissues within Organ Chips, such as those that mimic the lung and intestine, and researchers seek to understand how drugs, toxins or other perturbations alter tissue structure and function, the team at the Wyss Institute for Biologically Inspired Engineering led by Donald Ingber has been searching for ways to non-invasively monitor the health and maturity of cells cultured within these microfluidic devices over extended times.

To function, most of the newly - produced proteins first need to be sorted and then transported within and outside of the cell.

Some aim to reverse the age - related decline in the functioning of mitochondria — the multitude of tiny power - producing structures within cells.

The treatment not only led the spinal cord cells to produce and secrete ChABC in large quantities over areas spanning the injury epicenter, it helped to maintain the overall health of the damaged spinal cord and restored hind limb function in the animals within 12 weeks.

In a healthy mother, this enzyme is activated by hormones like insulin and insulin - growth factors (IGFs), kick - starting a relay race within cells which stimulates nutrient uptake and, as a result, normal growth and metabolic function.

However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study that found that restoring normal levels of a human colorectal cancer gene in mice stopped tumor growth and re-established normal intestinal function within only 4 days.

Delivering a single injection of a scar - busting gene therapy to the spinal cord of rats following injury promotes the survival of nerve cells and improves hind limb function within weeks, according to a study published April 2 in The Journal of Neuroscience.

Locked within each cell, it has no systemwide function.

«With this important advance, super-resolution microscopy and DNA - PAINT could become more accessible to biomedical researchers, accelerating our insights into the function of individual molecules and the processes they control within cells,» said Wyss Institute Founding Director Donald Ingber, M.D., Ph.D., who is also the Judah Folkman Professor of Vascular Biology at HMS and the Vascular Biology Program at Boston Children's Hospital, as well as Professor of Bioengineering at SEAS.

The HBP is responsible for producing modified glucose molecules that couple to numerous proteins, leading to beneficial changes in their function, stability, and location within the cell.

Colleagues of Ben - Ze «ev had examined the effect of turning off b - catenin on other, unrelated functions within cells.

Ruvkun's lab later demonstrated that the daf - 2 pathway functions specifically within the worm's neurons — and not elsewhere, such as in muscle cells — to control life span.

«I think our study strongly suggests that this is the case, and that each cell has a unique genetic program that's tailored to the function of a given cell within a neural circuit,» Greenberg said.

With the novel genetic access to hippocampal chandelier cells developed in the Taniguchi Lab at MPFI, neuroscientists can begin asking questions about the function of these cells within learning and memory circuits.

One theory has been that calorie restriction slows age - related degeneration and enables more efficient tissue function by influencing the integrity and activity of adult stem cells, the precursor cells that dwell within specific tissues and give rise to the diversity of cell types that compose that tissue.

The cells exhibited many functions associated with tumor progression; their presence within mouse tumors substantially accelerated cancer growth, and in human lung tumors, a SiglecFhigh neutrophil signature was associated with poor patient survival.

In their study, the scientists led by Dehio demonstrated for the first time a biological function of evolutionarily more ancestral FIC proteins, which still act within bacterial cells.

MicroRNAs are short molecules that work within all animal and plant cells, typically functioning as a «dimmer switch» for one or more genes, binding to the transcripts of those genes and preventing protein production.

Solving a puzzle of plant manipulation Rather than try to isolate single genes related to secondary cell wall production, the researchers looked at the function of hundreds of transcription factors working within the root xylem's regulatory network.

Alix therefore functions as a «molecular bridge» that also determines the polarity of individual epithelial cells, namely the way cells are oriented with respect to one another within the epithelial cell layer.

[The intracellular domain's function of] transcribing a gene into a protein that then performs some function within the cell generally takes about two hours, but we were seeing leakage within 30 minutes of blocking Notch1, further suggesting that whatever process controls the permeability of the barrier is operating via a completely different mechanism,» says Bill Polacheck, Ph.D., Postdoctoral Fellow at the Wyss Institute and co-first author of the paper.

«Our study revealed that one of these mechanisms involves metabolic stress - induced structural changes within liver cells that compromise their function.»

When the interaction of the cells within the cerebellum is disrupted, people experience fundamental disturbances in their motor function, making these simple actions difficult, or even impossible.

The mTOR protein is part of a complex that carries out a multitude of functions within cells, including the formation of synapses — the connections between neurons — their maintenance and plasticity.

But work by Conn and others revealed that, when the proteins are misfolded, the cell's «quality control system» misroutes them within the cell and they cease to function only because of that misrouting.

The mTOR protein is part of a complex that carries out a multitude of functions within cells, including the formation of synapses ---- the connections between neurons ---- their maintenance and plasticity.

The tumour killing functions of Natural Killer cells require energy and to meet this demand NK cells take on more fuel, which they burn within a metabolic engine to drive energy production.

Vital functions of an organism occur within cells, and all cells contain the hereditary information necessary for regulating cell functions and for transmitting information to the next generation of cells.

We use multiple mouse models combined with in vitro approaches to address the pleiotropic functions of these cytokines which affect both the epithelial cancer cells and the inflammatory infiltrate within tumors.

By combining SNP - targeting allele - specific silencing and gain - of - function approaches, we showed that a 46 - glutamine expansion in human HTT was sufficient for a dominant - negative effect on spindle orientation and changes in the distribution within the spindle pole and the cell cortex of dynein, p150Glued and NuMA in neural cells.

Taking advantage of infected patients, proprietary animal models of infection and new technological advances in the field of static and dynamic imaging, Immunopathology Unit tackles unresolved issues that include the means by which innate and adaptive immune cells traffic and function within the normal, cirrhotic or cancerous livers.

Proteins perform a variety of functions within the cell — from the breaking down and digesting fats to resisting foreign invaders, such as bacteria or viruses.

Current understanding of Bcl - xL's structure describes a protein with three regions — a core that interacts with proteins involved in cell death, a flexible region lacking defined structure (IDR) with an unknown function, and a membrane - anchoring region that attaches the protein to specific sites within the cell.

Also, by pooling this information from multiple independent cells, the function of cells can be examined within their context.

The drug disrupts the function of molecules found within cells, called androgen receptors, which help to transmit messages from androgens that tell cells to divide and grow.

Fusion of biological membranes is an essential process required for basic functions like transport of material within the cell, maintenance of cellular homeostasis and communication between cells.

Without these tools, scientists are less able to link specific genes to cell behavior or determine how microbes interact within their environment and with one another — critical information for understanding how ocean ecosystems function.

The research team at Mainz University speculates that whilst entanglements between chromosomes need to be removed for cell cycle progression those within a chromosome may not affect function and transmission of genetic information.