They included cloning (somatic cell nuclear transfer, accomplished in many placental mammals), stem
cell gametogenesis (has been done in mice), direct engineering of early stage embryos (has been done in several mammals), embryonic stem cell editing, and primordial germ cell (PGC) editing.
Not exact matches
Its happening now in a diploid germ
cell undergoing
gametogenesis in or near you, today!
In their latest study, they generated three different medaka mutants to demonstrate that the feminizing effect of germ
cells is not a result of the progression of
gametogenesis or a sexual fate decision of germ
cells.
The findings suggest that the information on the X and Y chromosomes that makes this division possible is primed during
gametogenesis — the process of creating ovum or sperm
cells — in the parents.
OCT - 4 is found in preimplantation - stage embryos and later confined to primordial germ
cells, and then, the expression during male and female
gametogenesis exhibits sex - specific down - regulation similar to SSEA1 [63].
However, it remains unclear whether primate ES
cells including those from humans can undergo
gametogenesis through meiosis in vitro, although immature germ
cell differentiation from primate ES
cells has been reported [5], [6], [7].
This is consistent with a model in which the pre-existing somatic
cell machinery underwent reproductive specialization during the evolution of
gametogenesis in multi-cellular ancestors.
The current findings could provide important clues to determine the culture conditions for promoting the differentiation of primate ES
cells into mature gametes, and to understand molecular mechanisms of primate
gametogenesis including the timing of germ
cell induction, the regulation of germ
cell gene expression, and the response to growth factors for germ
cell differentiation.
Altogether, this study reveals how a kinase integrates and transduces multiple signals to control key
cell - cycle transitions during Plasmodium
gametogenesis.