The T
cell gene codes for a protein that HIV uses to get into and infect a cell.
Not exact matches
The OAR proposal uses a variation of therapeutic cloning called altered nuclear transfer (ANT) in which the nucleus of a donor
cell (a skin
cell, for example), containing the 30,000
genes of the genetic
code, is altered in such a way that it produces an epigenetic factor, a protein called nanog.
Epigeneticists have found that our
cells carry a type of memory of the experiences of our ancestors — not only that, but 95 % of our
genes aren't yet
coded at birth, dependent on nurturing and the environment to determine their fate.
All animal
cells are made up of two genomes, the nuclear genome with 10,000 s of protein
coding genes and the mitochondrial genome with 13 protein - encoding
genes.
Some proteins that these
genes code for are known to be involved in stress and
cell death.
A virus containing the
gene that
codes for two molecular «switches» essential for turning skin
cells into brown fat was used to trigger the change (Nature, DOI: 10.1038 / nature08262).
Damage to human chromosome 9 (of the
cell's 24 pairs) where the
gene that
codes for E-NTPDase2 resides is known to cause eye and brain defects, such as microphthalmia — literally, small eyes.
The results show — for the first time, Briggs thinks — that the bacterial genomes change with depth: the micro-organisms at 554 metres carry more mutations in
genes that
code for energy - related processes like
cell division and biosynthesis of amino acids than are seen in their shallower counterparts.
These epigenetic modifications do not change the genetic
code, but may contribute to the inhibition of
gene expression, causing the
cells to produce smaller amounts of the corresponding proteins.
Scientists from Harvard University, the University of Pittsburgh, and the University of Missouri at Columbia devised another solution: inserting into pig
cells a
gene that
codes for an enzyme that converts omega - 6s to omega - 3s.
A second key
gene, SLC39SA13,
codes for a zinc transporter that helps nerve
cells to «decide» whether or not nerve impulses are amplified of dampened.
A third influential
gene was ARMS / KIDINS220, which
codes for a protein that regulates the growth of nerve
cells.
Sequencing the genome of one such organism, King and her colleagues found
genes that
code for pieces of the same proteins used for the binding of
cells and communication between
cells in animals — functions that would be unexpected in such an organism.
Several mutations were found in
genes coding the machinery that makes mitochondrial proteins, and so would probably hinder mitochondria's ability to make the chemical fuel called ATP, which is used by normal
cells.
The MDR1
gene codes for a protein that helps to extract drugs from
cells.
A European team of scientists has discovered how the
cells produce tiny pieces of RNA — called piRNA — that identify and silence «jumping
genes» or transposons:
genes that are able to change their position within the genome and therefore alter or disrupt the genetic
code.
The two
genes implicated — GNAQ and GNA11 —
code for proteins (known as G proteins) that normally function as molecular on - off switches, regulating the passage of information from the outside to the inside of a
cell.
These
genes code for proteins involved in transporting small containers called vesicles throughout the healthy
cell, but these proteins are often hijacked by viruses in order to move the virus through the
cell.
His trick was to insert the
gene coding for CREB into a version of the herpesvirus that can infect neurons without spreading to nearby
cells.
The new locus they have identified is near a cluster of
genes which
code for proteins called «glycophorins» that are involved in the malaria parasite's invasion of red blood
cells.
By comparing proteomic and RNA - sequencing data from people on different exercise programs, the researchers found evidence that exercise encourages the
cell to make more RNA copies of
genes coding for mitochondrial proteins and proteins responsible for muscle growth.
The team integrated three, complementary
gene sequencing approaches to look for mutations in tumor
cells from SS patients: whole - genome sequencing in six subjects, sequencing of all protein -
coding regions (exomes) in 66 subjects, and comparing variation in the number of copies of all
genes across the genome in 80 subjects.
Sickle
cell disease is a recessive genetic disorder caused by a single mutation in both copies of a
gene coding for beta - globin, a protein that forms part of the oxygen - carrying molecule hemoglobin.
Even more notable, Loki has
genes that
code for proteins involved in phagocytosis, the process by which one
cell can swallow another — and widely believed to be the way eukaryotes acquired mitochondria, a
cell's power source.
While all
cell types share the same genetic
code (DNA), certain
genes are specifically «expressed» or «silenced» in each
cell type.
By selectively adding or deleting stretches of DNA in the (artificially) fertilized
cell, scientists could knock out
genes for a disease like diabetes or insert
genes coding for extra height or intelligence.
Some of the
genes involved help regulate the flow of ions in and out of the
cells, particularly nerve
cells; others
code for so - called heat shock proteins that are typically induced during stress.
The researchers used the power of
gene sequencing and clever computational methods to uncover the «source
code» for human endothelial
cells and learn how that
code is disturbed in human disease.
They looked specifically for
genes coding the major histocompatibility complex (MHC)-- a molecule found on the surface of
cells that acts as a crucial component of the immune systems of most vertebrates.
Most resistance
genes, in wheat and other plants,
code for protein receptors located inside
cells; the Stb6
gene codes for a receptor protein on the
cell's surface.
Working with cultures of respiratory tract
cells, Elias's team found that the
gene that
codes for il - 6 is inactive unless a protein known as nf - kb (nuclear factor - kappa beta) attaches to the
gene.
Dr. Ella Evron and Dr. Ayelet Avraham of the TAU - affiliated Assaf Harofeh Medical Center, together with Prof. Saraswati Sukumar of Johns Hopkins, have found that «
gene regulation,» the process that shuts off certain parts of a
cell's DNA
code or blueprint in healthy breast tissue
cells, may also play a critical role in the development of breast cancer.
We found 20
genes that distinguished motor neurons that innervate digit muscles from the others, and there's a strange
gene code involved in the
cells» development.
The
gene in question, apolipoprotein E (apoE),
codes for a protein in the brain's astrocyte
cells that seems to help spur nerve
cell growth and clear up debris from neuronal injuries brought by head trauma, stroke, or cerebral hemorrhage.
While the genetic
code carried in our DNA provides instructions for
cells to manufacture specific proteins, it is a second
code that determines which
genes are in fact activated in particular
cell types.
This
gene codes for part of a pore in nerve
cells called a potassium channel that is vital for transmitting nerve impulses to adjoining
cells.
The mutated
gene, FAA,
codes for an aberrant, as - yet - unnamed protein that initiates a cascade of malfunctions in various body systems, including production of blood
cells and platelets in the bone marrow.
Of dozens of
genes strongly activated by injury, seven
coded for proteins that are secreted from
cells.
According to the 6 April report in the Journal of Assisted Reproduction and Genetics, researchers at Guangzhou Medical University in China attempted — with limited success — to modify the CCR5
gene, which
codes for a
cell receptor that the HIV virus uses to enter T
cells.
James Reid and his colleagues at the University of Tasmania in Hobart will report in the August issue of The Plant
Cell that the tallness
gene codes for an enzyme involved in the manufacture of the growth hormone gibberellin.
The vast majority of our 20,000 or so
genes exist in the DNA within each
cell's nucleus, as distinct from the 13 protein -
coding genes inside mtDNA.
PARIS — As scientists race to finish a rough draft of the human genome, a European consortium is about to launch an effort to pinpoint every key spot in our genetic
code where
cells turn
genes on and off by adding a molecule called a methyl group.
The new AAV vectors can also deliver
genes that
code for colorful fluorescent proteins; such proteins are useful in identifying and labeling
cells.
In many cancerous
cells, p53 doesn't work because the
gene coding for it has mutated.
Wondering why the third protein, an enzyme called p66, was not, despite being very similar to the other two, Pelicci's team knocked out the piece of the
gene that enabled it to
code for p66, in order to make mice and mouse embryonic
cells that lacked p66.
The
gene codes for an immune receptor on red blood
cells; lack of that receptor prevents infection by Plasmodium vivax, a species of the malaria parasite.
That DNA includes slightly less than 21,000 protein -
coding genes (some researchers once estimated we had more than 100,000 such
genes); «
genes» for 8800 small RNA molecules and 9600 long noncoding RNA molecules, each of which is at least 200 bases long; and 11,224 stretches of DNA that are classified as pseudogenes, «dead»
genes now known to really be active in some
cell types or individuals.
The team, which included members of the Health Science Center departments of medicine and biochemistry, investigators from the UT Southwestern Medical Center at Dallas and a group of collaborators from Austria, found that the
gene that
codes the enzyme D2 - hydroxyglutarate dehydrogenase (D2HGDH) is mutated in a subset of cancers called diffuse large B -
cell lymphomas.
With just 121 protein -
coding genes, the diminutive Tremblaya princeps, a symbiotic bacterium that lives inside specialized
cells of the sap - eating mealybug, has the smallest known genome of any cellular organism on the planet.
If so, it could make
cell fate more resilient to random mutations in a plant's genetic
code, even when such changes keep some
gene - regulating proteins from binding their intended DNA targets.