Sentences with phrase «cell genes studied»

Even cells at the top of the hierarchy generally express only a subset of the stem cell genes studied.

Not exact matches

I'm helping a group study a cell line that has been engineered to remove a particular gene.

He attended UC Berkley and Sonoma State University where he studied Cell Biology and worked at the USDA Plant Gene Expression Center.

This study built on previous research from the Sundrud lab, which showed that when TH17 cells entered the intestine in human tissue samples, they increased the expression of a gene called MDR1.

Specifically, the study reveals a mechanism that helps explain how dividing cells pass patterns of epigenetic information called methyl tags to their daughter cells, a crucial part of regulating gene expression across cell generations.

The shared patterns of gene expression in the limbs and phallus are generated in part by a common set of noncoding DNA, also called «elements» or «enhancers,» which act to control gene expression in both of these structures, argues a study published October 1 in Developmental Cell.

McCallion's strategy to make sense of all this data looks at the active genes in cells affected by a disease, groups of genes that interact with one another, their vulnerability to mutation and information from past scientific studies to filter more than a thousand gene candidates for disease risk down to just a handful within any one implicated region.

The study, led by Dr Len Stephens and Dr Phill Hawkins and published today in the journal Molecular Cell, reveals why loss of the PTEN gene has such an impact on many people with prostate cancer, as well as in some breast cancers.

A little - studied gene may explain how some liver cancer cells obtain the nutrition they need to proliferate, according to new research from the University of Maryland.

They also looked for genes not previously studied for having a role in fusing muscle stem cells.

«Combination therapy strengthens T cells in melanoma pre-clinical study: Findings have implications for treating tumors lacking tumor suppressor gene PTEN.»

A pre-clinical study of two drugs designed to boost T cell performance, has revealed the agents, when give in combination, may enhance the immune system's ability to kill melanoma tumors deficient in the tumor suppressor gene PTEN.

«One gene closer to regenerative therapy for muscular disorders: Study identifies gene that gets muscle cells to fuse together.»

Led by researchers at the Cincinnati Children's Hospital Medical Center Heart Institute, the study demonstrates the gene Gm7325 and its protein — which the scientists named «myomerger» — prompt muscle stem cells to fuse and develop skeletal muscles the body needs to move and survive.

Sutherland says the genes she studies are already silenced in healthy adult tissue, so theoretically researchers should be able to design therapies that re-silence them in cancer cells without side effects.

RNAScope ISH was developed by Advanced Cell Diagnostics (ACD) Inc., initially for studies of gene expression in animal (and especially human) tissues.

New treatments for spinal cord injury, including stem cells, gene therapy and electrical stimulation, are being studied.

The gene makes a protein that controls the quantities of other proteins a cell produces, and studies in roundworms suggest that the gene is involved in growth and development throughout life.

Yang said the study not only indicated which genes are affected by traumatic brain injury and linked to serious disease, but also might point to the genes that govern metabolism, cell communication and inflammation — which might make them the best targets for new treatments for brain disorders.

This fits with studies we've conducted in the past in which we found that the gene primes blood stem cells for leukaemic transformation.»

Although the regulation of this gene has a strong «cell cycle control» component, I was more interested in studying cell cycle regulation «proper.»

According to Izpisúa Belmonte, who is also a professor at the gene expression laboratories of the Salk Institute for Biological Studies in San Diego, California, CMRB aims to become «a research centre of excellence in south Europe in the line of world - recognized institutions such as the Salk or the Whitehead institutes, where both pre - and postdoctoral researchers receive multidisciplinary training of the highest quality» in stem cell biology and cell regeneration.

Bloch's colleagues at the National Institute of Environmental Health Sciences tested the oils in gene expression studies on lab - grown human breast cancer cells and found that they could mimic estrogens, the primary female sex hormones, and inhibit androgens, the primary male sex hormones.

After having conducted a large - scale study performed on cells from the umbilical cords of 204 newborns, the researchers from UNIGE demonstrate that DNA methylation may play both a passive and active role in gene regulation.

To more accurately reflect the mechanisms driving oligodendrogliomas, the researchers used RNA sequencing to study directly, on a single - cell level, gene expression in samples from six early - stage human tumors.

So far, researchers have mostly turned on genes with CRISPRa in cells growing in lab dishes, says Charles Gersbach, a biomedical engineer at Duke University not involved in the new study.

In the study, they found that miR - 182 suppressed Bcl2L12, a cancer gene that blocks cancer cell death in response to chemo - and radiation therapy.

While previous vectors have only been able to penetrate the cochlea's inner hair cells, the first Nature Biotechnology study showed that a new synthetic vector, Anc80, safely transferred genes to the hard - to - reach outer hair cells when introduced into the cochlea (see images).

«This study shows that NF - kB might coordinate a network of immune - suppressor genes whose products enable tumor cells to evade adaptive immunity,» he adds.

Nadeau stumbled upon one study, in mice, describing how environmental factors can tag Foxp3 with chemical markers that tell T - cell precursors to switch the gene on or off.

The result was the largest deletion ever observed in the dystrophin gene using CRISPR / Cas9, and the study was the first to create corrected human iPS cells that could directly restore functional muscle tissue affected by Duchenne.

In the latest study, the researchers hypothesize that the downregulation of these three genes reprograms the cells so that they return to an embryonic - like state, in which they have the potential to give rise to a number of different cell types.

And by studying mice lacking the gene for ERRγ (and therefore unable to make the ERRy molecule), the team observed that all brown fat cells resembled white cells in these mice.

She still does not know why he considered her at the time — «Maybe it was just my enthusiasm,» she wonders — but he nonetheless became her mentor as she studied the transcriptional activation of the cell - cycle regulated HO gene in the yeast Saccharomyces cerevisiae.

«Our stem cell - based studies indicate that low - calorie sweeteners promote additional fat accumulation within cells compared with cells not exposed to these substances, in a dose - dependent fashion — meaning that as the dose of sucralose is increased more cells showed increased fat droplet accumulation,» said Sabyasachi Sen, M.D., Associate Professor of Medicine at George Washington University in Washington, D.C. «This most likely occurs by increasing glucose entry into cells through increased activity of genes called glucose transporters.»

This study, published in the journal Microarrays, shows that lack of SOST in the bone microenvironment promotes the expression of many genes associated with cell migration and / or invasion, including long non-coding RNA MALAT1 in prostate cancer, suggesting that SOST has an inhibitory effect on prostate cancer invasion.

«We have identified the molecular mechanisms by which the Tat protein made by HIV interacts with the host cell to activate or repress several hundred human genes,» said Dr. Iván D'Orso, Assistant Professor of Microbiology at UT Southwestern and senior author of the study.

Underscoring the relevance to humans, the researchers studied nasal and bronchial cells from people who suffer from asthma or chronic rhinosinusitis (nasal congestion / sniffles) due to dust - mite sensitivity, and found that on average these cells had a markedly lower expression of the dectin - 1 gene.

By studying infected cells grown in a laboratory, the team found that a large number of CMV's genes help it hide from the immune system by allowing it to destroy many of the proteins produced by the body during virus infection and preventing them from activating immune cells to destroy the virus.

«In this current study, we've shown that by opening the TRPV1 channel to allow calcium ions to enter the cell, we can turn on a gene.

In one such study by Ronald Evans and colleagues, the gene for rat growth hormone is stably inserted into mouse cells by a retrovirus.

Nevertheless,» [the] study is very important because it demonstrates for the first time that we can use gene therapy to transform cells in the brain into ones that will secrete GDNF,» says Jeffrey Kordower, a professor of neurological sciences at Rush Presbyterian Medical Center in Chicago.

The results of the study were obtained by infecting laboratory - grown cells with forms of the CMV virus which differed only by the removal of a single gene.

Visel and his colleagues studied gene expression in a developing mouse embryo, and found 120 enhancers active in cells of the face.

A study in this week's Neuron provides key evidence that DNA methylation — also known to occur as cancerous cells divide, when tumor suppressor genes are silenced — occurs in adult brains and can be triggered by environmental cues.

Previous studies of genetic alterations in lymphoma and lung cancer have found that certain genetic mutations — specifically when part of a gene breaks off and gets fused to another — can inappropriately switch on ALK, driving cancer cells to grow and divide.

Among all the genes that control endocytosis, the authors of the study focused specifically on one, called RAB7; this gene is highly expressed in melanoma cells.

Co-senior author Professor Jennifer Nichols at the Wellcome Trust - Medical Research Council Stem Cell Institute, said: «Our data allow us to study gene activity in individual cells to an unprecedented level of precision.

The researchers also anticipate that their gene expression data and newly described islet - cell isolation technique, coupled with the ongoing tissue procurement effort, will be helpful to others studying pancreatic development and diabetes.

In those cells the Esrp1 and Esrp2 proteins enforce epithelial - specific splicing isoforms for hundreds of different genes, as Carstens and his team have shown in studies since 2009.