Sentences with phrase «cell genomes»

Single - cell genome analyses reveal the amount of mutations a human brain cell will collect from its fetal beginnings until death.
Moreover, cancer cell genomes rapidly evolve in response to environmental pressures, a feature that enables the cells to develop drug resistance.
But in practice, editing T cell genomes with CRISPR / Cas9 has proved surprisingly difficult, said Alexander Marson, PhD, a UCSF Sandler Fellow, and senior and co-corresponding author of the new study.
Her family will also be acknowledged in articles or talks resulting from the use of HeLa cell genome data.
«Multiclonal invasion identified in early breast tumors by topographic single cell genome sequencing»
Recently, the system has been further refined to allow removal of integrated transgenes from the host cell genome after reprogramming [7].
«Access to HeLa cell genome data restored following agreement.»
The assembly and analysis of human tumor cell genomes, many of which contain chromosome deletions, duplications and insertions, as well as single nucleotide changes, requires immense data storage capacity and high - speed computation.
To be also able to characterize the single cell genome and epigenome, we are developing new approaches for the identification of somatic alterations or open chromatin states.
Specially formulated to enhance single cell expansion in the cloning step of stem cell genome editing, StemFit Basic02 offers superior and stable growth performance, high colony forming efficiency and robust scalable cell expansion.
The hack that gives CAR T cells their cancer - killing abilities relies on a specially designed surface molecule called a chimeric antigen receptor (CAR)-- and hence the technique's name — which scientists incorporate into T cell genomes using a modified virus.
In SIF - seq, hundreds or thousands of DNA fragments to be tested for enhancer activity are coupled to a reporter gene and targeted into a single, reproducible site in embryonic cell genomes.
To achieve their goals, the team refined a CRISPR - Cas9 technique to efficiently disrupt all genes in the leukemia cell genome individually..
«Starting 2007, the first single - cell genomes from environmental cells appeared in public databases and they are draft assemblies with fluctuations in the data quality.
However, iPSC technology has been making great leaps and bounds in the three years since their creation; researchers have found ways of making iPSCs with non-integrating vectors (Yu et al., 2009) and, more recently, have created iPSCs without directly altering the adult cell genome at all but instead delivered the key reprogramming proteins to the cells (Zhou et al., 2009).
By obtaining outer thigh muscle biopsies from healthy volunteers and sequence the satellite cell genomes, the team was able to demonstrate that these stem cells accumulate mutations during life.
Navin's team developed Nuc - Sec as a single - cell genome sequencing method and applied it to study how cell mutations occur in both types of breast cancer.
«Heart toxin reveals new insights into HIV - 1 integration in T cell genome: Digoxin exposes link between T cell activation and targeted HIV - 1 integration in specific genes.»
Any researcher wanting to use the HeLa cell genome in their research has to request the data from this committee, and explain their research plans, and any potential commercialisation.
A Chinese research team has now developed a gold - nanoparticle - based multifunctional vehicle to transport the «gene scissors» to the tumor cell genome.
They also re-engineered their previous gene editing apparatus to now carry a set of four guide RNAs, all designed to efficiently excise integrated HIV - 1 DNA from the host cell genome and avoid potential HIV - 1 mutational escape.
The alterations leading to tumour development are due to multiple changes in cell physiology and specifically in the cell genome.
«These extensions complement the MIxS suite of metadata standards by defining the key data elements pertinent for describing the sampling and sequencing of single - cell genomes and genomes from metagenomes,» said GSC President and study co-author Lynn Schriml of the Institute of Genome Sciences at University of Maryland School of Medicine.
Overall, Efroni et al. suggested that the differentiation of ESCs may correlate with a loss of active transcription of the cell genome.
CRISPR / Cas9 can also deliver the CAR gene to a very specific site within the T cell genome, which may reduce the risk of gene insertion at incorrect or undesired locations.
* Acute promyelocytic leukaemia is caused by the modification of two genes, RAR and PML, leading to the development of cancer cells; ** the gene coding for p53 protein plays an essential role in cell proliferation under normal conditions and in maintaining the integrity of the cell genome.
And clearly we still have not fully grasped the issues at hand, as in 2013 researchers sequenced the HeLa cell genome — and published it.
In addition to human error, fragments of DNA from the helper plasmids or the cell genome can be packaged inside the vectors during production.
We compared blood CD3 + T cells genome - wide promoter methylation profiles of two groups: adult males who had been shown to be on a CPA trajectory between 6 and 15 years of age and males with the same background who followed a normal physical aggression trajectory (control group)[9], [12].
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