Sentences with phrase «cell genomics in»

Alexander J, Kendall J, McIndoo J, Rodgers L, Aboukhalil R, Levy D, Stepansky A, Sun G, Chobardjiev L, Riggs M, Cox H, Hakker I, Nowak DG, Laze J, Llukani E, Srivastava A, Gruschow S, Yadav SS, Robinson B, Atwal G, Trotman L, Lepor H, Hicks J, Wigler M, Krasnitz A. Utility of single - cell genomics in diagnostic evaluation of prostate cancer.

Not exact matches

Human Longevity has already received $ 70 million in private backing and aims to use both genomics and stem cell therapies to allow us to live longer, healthier lives.

Venter reiterated this sentiment: «Using the combined power of our core areas of expertise — genomics, informatics, and stem cell therapies, we are tackling one of the greatest medical / scientific and societal challenges — aging and aging related diseases,» he said in a statement.

HLI, a privately held company headquartered in San Diego, CA was founded in 2013 by pioneers in the fields of genomics and stem cell therapy.

Using advances in genomic sequencing, the human microbiome, proteomics, informatics, computing, and cell therapy technologies, HLI is building the world's most comprehensive database of human genotypes and phenotypes as a basis for a variety of commercialization opportunities to help solve aging related disease and human biological decline.

Chan's laboratory uses genomic analyses to identify neoantigens — novel peptides found only in tumors that arise from mutations accumulated by cancerous cells.

Because every cell type in a mammalian organism requires access to genomic areas in a tempo - spatial specific manner, the epigenome is crucial for determining cellular identity.

«However, because SIF - seq only requires DNA sequence from a mammal and can be used in a variety of cell types, it should be possible to compare the neuronal enhancers present in a large genomic region from human to the neuronal enhancers present in the orthologous chimpanzee region.

Last week, genomics pioneer Craig Venter announced that his team has passed an important milestone in its efforts to create a bacterial cell whose genome is entirely synthetic — constructed chemically from the building blocks of DNA.

Traditional genetic approaches together with the new wealth of genomic information for both human and model organisms open up strategies by which drugs can be profiled for their ability to selectively kill cells in a molecular context that matches those found in tumors.

«We feel it's critical that the scientific community consider the potential hazards of all off - target mutations caused by CRISPR, including single nucleotide mutations and mutations in non-coding regions of the genome,» says co-author Stephen Tsang, MD, PhD, the Laszlo T. Bito Associate Professor of Ophthalmology and associate professor of pathology and cell biology at Columbia University Medical Center, and in Columbia's Institute of Genomic Medicine and the Institute of Human Nutrition.

Since the completion of the Human Genome Project in 2003, scientists have expanded their knowledge of how living cells work with new approaches including genomics, proteomics, and systems biology.

Fanconi anemia (FA) is a genomic instability syndrome caused by mutations inside a cluster of proteins normally responsible for DNA repair in cells.

The technique analyzes the spatial organization of chromatin in a cell and detects all the genomic regions that interact with a particular region of interest.

As costs come down and methods become more standardized, experts in the field expect single - cell sequencing to become the new model for both transcriptomic and genomic studies.

Twenty - first century science is driven, in large part, by challenges at interfaces, including those between the environmental and life sciences — public health, ecology, genomics, cell biology, epidemiology, immunology, neurobiology, physiology, evolutionary biology... and the mathematical sciences.

Genomic RNA editing and its impact on Ebola virus adaptation during serial passages in cell culture and infection of guinea pigs

In a recent proof - of - concept experiment, Abate and his colleagues performed single - cell genomic sequencing on a sample of seawater.

The following year, a paper by Ben Lehner's group at the Center for Genomic Regulation in Barcelona, Spain, drove the point home: When a cell produces too many of these proteins, they found, it dies.

The Molecular Sciences Institute in Berkeley, California, combines genomic experimentation and computer modeling to predict the behavior of cells and organisms in response to genetic and environmental changes.

In particular, the published study states that, when root stem cells die due a genomic stress, a signal of steroid hormones is sent to reservoir stem cells so that these divide and replace the damaged ones.

Nagy admits the promise of personalized cell regeneration is probably too costly for mainstream use, and he believes genomic editing — in which DNA is inserted or deleted — is key to safe iPS cell implants.

«Our paper reports that two highly conserved pathways — the UPR and the nonsense - mediated RNA decay pathway — intersect with each other at a pivotal point in cell stress,» said Miles Wilkinson, PhD, senior author and professor in the Department of Reproductive Medicine and a member of the UC San Diego Institute for Genomic Medicine.

Lead author Moustafa Abdalla writes: «Almost all genomic studies of breast cancer have focused on well - established tumours because it is technically challenging to study the earliest mutational events occurring in human breast epithelial cells.»

«There's some concern that if you had Cas9 in your cells for too long of a period of time, it might cause some genomic instability,» Anderson says.

Another limitation is that materials genomics has been hitherto applied almost exclusively to what engineers call functional materials — compounds that can perform a task such as absorbing light in a solar cell or letting electrical current pass in transistor.

Published in the March 31 advance online issue of Cell, their findings reveal that circular RNAs — like their protein counterparts — are also affected by genomic rearrangements in cancer, resulting in abnormal fusions.

Recent advances in single - cell genomics technology has made it possible to separate individual cells from different tissues and organs, and measure the sets of RNA messages — called the transcriptome — which help give each cell its own identity.

«Most aging cells develop genomic changes that make them more susceptible to the carcinogens in the environment,» says oncologist Lodovico Balducci, who studies and treats cancer in the elderly at the Moffitt Cancer Center in Tampa, Fla..

But in an Opinion paper published June 16 in Trends in Cell Biology, researchers propose that new genomic evidence derived from a deep - sea vent on the ocean floor suggests that the molecular machinery essential to eukaryotic life was probably borrowed, little by little over time, from those simpler ancestors.

Research led by Ed Morrisey, PhD, professor of Medicine and Cell and Developmental Biology in the Perelman School of Medicine, University of Pennsylvania and scientific director of the Penn Institute for Regenerative Medicine, has identified hundreds of these lncRNAs, sometimes called the «genomic dark matter,» that are expressed in developing and adult lungs.

Those switches can be both near and far from the gene they regulate and act in different combinations in different cell types to give each cell type a unique genomic identity.

Hsp genes are a family of proteins produced by cells in stressful situations, ranging from high temperatures to ultraviolet light exposure to maintain genomic integrity.

In collaboration with the team of Eduard Sabidó at the Proteomics Unit of the Centre for Genomic Regulation and Universitat Pompeu Fabra, the researchers analyzed the proteins in Capsaspora to determine how the organism might be regulating its internal cell processes at different life stageIn collaboration with the team of Eduard Sabidó at the Proteomics Unit of the Centre for Genomic Regulation and Universitat Pompeu Fabra, the researchers analyzed the proteins in Capsaspora to determine how the organism might be regulating its internal cell processes at different life stagein Capsaspora to determine how the organism might be regulating its internal cell processes at different life stages.

The specific genomic region where this non-coding RNA is located often gets damaged in breast cancer patients — this control is removed and the cancer cells spread.»

A strategic focus is to continue to develop computational tools (such as KinomeXplorer, NetworKIN, and NetPhorest) and to deploy these on genome - scale quantitative data obtained by, for example, mass spectrometry, genomic, and phenotypic screens to understand the principles of how spatio and temporal assembly of mammalian signaling networks transmit and process information at a systems level in order to alter cell behavior.

Genomic data from the HeLa cell line are also being released with the final version of the paper as a result of discussions between leaders of the National Institutes of Health (NIH) and relatives of Henrietta Lacks, from whose cervical tumor the original HeLa cell line was derived prior to her death in 1951.

The genomic particularities of HeLa cells relate to their origin from an aggressive cancer and subsequent cultivation in laboratories for decades, both of which cause considerable genomic alterations.

The new study, a comprehensive analysis of the genomes of 178 primary cervical cancers, found that over 70 percent of the tumors had genomic alterations in either one or both of two important cell signaling pathways.

The advent of genomics and rapid sequencing techniques has seen HeLa cells used in numerous large - scale studies of gene function and expression.

Importantly, all researchers who use or generate full genomic data from HeLa cells will now be asked to include in their publications an acknowledgement and expression of gratitude to the Lacks family for their contributions.

The article, «The Genomic and Transcriptomic Landscape of a HeLa Cell Line,» by Landry et al., was authored by scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, and was published in an early online version March 11, 2013.

Using this method, features of genomic organization including compartments, topologically associating domains (TADs) and chromatin loops were detected in single cells when averaged over the genome.

Particularly exciting, he says, are advancements in genomics — his specialty — that have begun to unlock some of the deepest secrets of the origins of life, including the evolutionary history of cells and their genes.

L1 - associated genomic regions are deleted in somatic cells of the healthy human brain.

The new study demonstrates how a wide range of mutations can be corrected in human cells by eliminating abnormal splice sites in the genomic DNA.

By using results of their genomic studies, the team estimated the fraction of cancer cells in which a mutation was likely to occur.

Researchers from the Centre for Genomic Regulation (CRG) in Barcelona have now described a novel mechanism by which adult cells can be reprogrammed into iPS cells successfully and in a very short period of time.

Coleman added that further research is needed to determine whether cell fusion events between normal human cell types result in genomic catastrophe and neoplastic transformation.

A group of researchers from the Centre for Genomic Regulation in Barcelona have discovered a faster and more efficient mechanism for reprogramming induced pluripotent stem cells (iPS).