Sentences with phrase «cell genomics study»

Published in Nature, the single - cell genomics study was led by the European Bioinformatics Institute (EMBL - EBI) and the University of Cambridge.

Not exact matches

«The hope is that ZPF217 could be used to maintain supplies of therapeutic stem cells,» said lead study author Martin Walsh, PhD, Associate Professor of Pediatrics, Structural and Chemical Biology, and Genetics and Genomic Sciences of the Icahn School of Medicine at Mount Sinai.

A study analyzing brain tumor genomics on a single - cell level has found evidence that cancer stem cells fuel the growth of oligodendrogliomas, a slow - growing but incurable form of brain cancer.

As costs come down and methods become more standardized, experts in the field expect single - cell sequencing to become the new model for both transcriptomic and genomic studies.

In particular, the published study states that, when root stem cells die due a genomic stress, a signal of steroid hormones is sent to reservoir stem cells so that these divide and replace the damaged ones.

Lead author Moustafa Abdalla writes: «Almost all genomic studies of breast cancer have focused on well - established tumours because it is technically challenging to study the earliest mutational events occurring in human breast epithelial cells.»

«Most aging cells develop genomic changes that make them more susceptible to the carcinogens in the environment,» says oncologist Lodovico Balducci, who studies and treats cancer in the elderly at the Moffitt Cancer Center in Tampa, Fla..

The new study, a comprehensive analysis of the genomes of 178 primary cervical cancers, found that over 70 percent of the tumors had genomic alterations in either one or both of two important cell signaling pathways.

The advent of genomics and rapid sequencing techniques has seen HeLa cells used in numerous large - scale studies of gene function and expression.

«This groundbreaking study sets the stage for more exacting research, using the latest genomic technologies and aimed at developing new therapies that could help the tens of thousand of patients who urgently need our help,» said Dr. Nhan Tran, an Associate Professor of TGen's Cancer and Cell Biology Division and the study's other co-senior author.

Researchers from the University of Michigan and the Mayo Clinic studied rat IEC - 6 intestinal epithelial cells, chosen because they maintain a stable diploid genomic structure (two sets of chromosomes), lack the cellular characteristics of cancer cells, and replicate normally.

The new study demonstrates how a wide range of mutations can be corrected in human cells by eliminating abnormal splice sites in the genomic DNA.

By using results of their genomic studies, the team estimated the fraction of cancer cells in which a mutation was likely to occur.

Senior toxicologists say the field of toxicology is undergoing a big change as pressure mounts to reduce animal use and genomics, proteomics, and other cell - based and molecular techniques supersede whole - animal studies.

Prof Timothy Aitman, Director of the University of Edinburgh's Centre for Genomic and Experimental Medicine, who co-led the study, said: «Our findings give us insight into how cells in the body adapts to injury.

The study compared multiple techniques — or assays — used to analyze genomic data from a glioblastoma patient's tumor cells and normal healthy cells.

The study explains for the first time that the suppression of histone 1 causes cell damage and genomic instability (DNA damage).

«Studies are underway to interrogate the genomic signature of circulating pancreas cells from patients with precancerous cystic lesions,» says Rhim.

He and his colleagues employ pharmacologic, brain imaging, epidemiologic, genomic, and cell model approaches to study schizophrenia and bipolar disorder, in particular.

In addition to Doñana Biological Station (EBD - CSIC), also taking part in the project were the National Center for Genomic Analysis (CNAG - CRG); the Centre for Genomic Regulation (CRG); the Spanish National Cancer Research Center (CNIO); the Evolutionary Genomics Group of the Hospital del Mar Medical Research Institute (IMIM); the Institute of Evolutionary Biology (IBE, CSIC - UPF); the University Institute of Oncology of Asturias (IUOPA); the Institut de Biotecnologia i de Biomedicina and the Unit of Cell Culture of the Autonomous University of Barcelona (UAB); the Biological Research Center (CIB - CSIC) and the Catalan Institution for Research and Advanced Studies (ICREA).

«Over the last several years, single - cell genomics has become a popular tool to complement metagenomics,» said study senior author Tanja Woyke, head of the DOE JGI Microbial Program.

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In a previous study, Shaw, an associate professor in Salk's Molecular and Cell Biology Laboratory and researcher in the Institute's new Helmsley Center for Genomic Medicine, demonstrated that cells lacking a normal copy of the LKB1 gene fail to activate AMPK in response to low energy levels.

Because alleles found to be mutated only once in 5,338 tumors rendered cells tumorigenic, these observations underscore the value of integrating genomic information with functional studies.

In a study being published online today in the journal Cell, researchers in the laboratory of Gladstone Senior Investigator Benoit Bruneau, PhD, employed stem cell technology, next - generation DNA sequencing and computing tools to piece together the instruction manual, or «genomic blueprint» for how a heart becomes a heCell, researchers in the laboratory of Gladstone Senior Investigator Benoit Bruneau, PhD, employed stem cell technology, next - generation DNA sequencing and computing tools to piece together the instruction manual, or «genomic blueprint» for how a heart becomes a hecell technology, next - generation DNA sequencing and computing tools to piece together the instruction manual, or «genomic blueprint» for how a heart becomes a heart.

Under the mentorship of Micheala Aldred, PhD, Associate Staff of the Genomic Medicine Institute, Dr. Drake has studied the effect of experimental drugs on cultured lung or blood cells isolated from PAH patients.

Researchers in NCI's Division of Cancer Epidemiology and Genetics (DCEG) integrate tissue profiling into studies examining the causes of cancer to better understand the process by which normal cells are transformed into cancer cells (carcinogenesis) and to pinpoint factors associated with risk for developing specific molecular or genomic subtypes.

Team Identifies Genetic Abnormalities in Stem Cell Lines — The study, from the Loring lab, suggests the need for frequent genomic monitoring of stem cells to assure their stability and clinical safety.

We use various approaches including genetics, genomics and cell biology to study gene functions in normal development and disease such as cancer.

Not so long ago, the advent of powerful genomic tools and genetic engineering techniques made it seem that studies involving mice engineered to carry human disease genes would be the best approach for exploring human disorders, superior to looking at cells isolated in a laboratory.

Studying the epigenetic setting of germ cells allows investigating several crucial aspects of mammalian biology such as transposon control, genomic imprinting and early lineage commitment.

The scientific goal of the Cancer Biology Program is to identify novel genomic and genetic alterations that play causal roles in cancer development and to study genes, proteins, and signaling pathways that mediate the altered phenotypes of cancer cells.

The Kind group studies the regulation of gene expression in single cells by developing and using novel microscopy and genomics based techniques.

To uncover molecular processes in individual cells and to understand the full complexity of biological systems, our lab applies and develops novel microscopy and genomics based techniques to study the regulation of gene - expression in single cells.

Importantly, these studies to elucidate gene contacts in the 3D nuclei of live cells have demonstrated that condensin - mediated contacts between centromeres and the genomic loci carrying Pol III - transcribed genes or retrotransposons are highly dynamic.

These studies illustrate the immense potential of single - cell genomics to open up a new era in developmental and evolutionary research.

For Swanton, «these studies led to the idea that integrating genomics and cell biology could start to inform mechanisms of disease and ways to target those mechanisms with therapies.»

By detailing certain features of cells and tissues, such as methylation patterns, protein levels and other characteristics, Dr. Volpi said that the new studies will «help paint a clearer picture of how genomic variation leads to particular diseases.»

Since the first single - cell RNA - sequencing (scRNA - seq) study was published in 2009, many more have been conducted, mostly by specialist laboratories with unique skills in wet - lab single - cell genomics, bioinformatics, and computation.

To pursue these studies, we employ Hi - C and ChIA - PET genomic technologies and single locus / live - cell imaging approach.

To pursue these studies, the Noma laboratory employs genomic technologies and single locus / live - cell imaging technology along with molecular and chromatin biology and epigenetics.

Genomic studies, which in principle group together co-regulated genes, can potentially identify new components of known regulatory pathways in ES cells that can subsequently be explored in functional studies.

Single cell genomics means that one can study the genetic material of single cells.

We apply cell / molecular biology, biochemistry, and genetics / genomics to study three areas related to cardiovascular disease.

We apply personalised functional genomics to study diseases in patient - derived cells using systematic and targeted approaches to unravel mechanisms and discover novel treatments (see video).

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