Not exact matches
Over a lifetime, an overactive immune system will contribute to an overproduction of AGE's, advanced
glycation end products, initiating oxidative reactions within
cells that will gradually damage organs throughout the body.
The investigators also discovered that neutrophils secrete a molecule called S100A8 / S100A9 that interacts with a receptor named RAGE (the Receptor for Advanced
Glycation Endproducts) on bone marrow
cells.
High advanced
glycation end - products overwhelm innate defenses of enzymes and receptor - mediated endocytosis and promote
cell damage via the pro-inflammatory and pro-oxidant receptor for advanced
glycation end - products.
Reber, F., Reber, U. and Funk, R.H. Intracellular changes in astrocytes and NG 108 - 15 neuroblastoma X glioma
cells induced by advanced
glycation end products.
Many different types of sugary molecules known as advanced
glycation end - products (AGEs) end up in the spaces between
cells and can react with and link together the intricate structures of the extracellular matrix.
A transcriptome research of its organs revealed its gene signature is highly evolved and adapted for extreme longevity (slow metabolism, improved insulin gene signaling and glucose homeostasis, thus reduced blood glucose, improved cancer genes, improved endothelial function by eNOS (endothelial Nitric Oxide Synthase) meaning improved vascular coronary blood flow, improved microvasculature arterial and heart endothelium function) but more importantly, to answer your question, some whales display low blood glucose hypoglycemia, this affects the quantity and period of proteins / DNA /
cell exposure to glucose
glycation, glycosylation and glycoxydation reactions.
This has several positive effects, here's a few: (a) because blood sugar levels are low, there won't be any further damage to
cells from
Glycation (high blood sugar kind of «fries» a
cell, like a grilled cheese sandwich — literally.)
These massive blood sugar spikes also contribute to
glycation in the
cells of your body, which basically makes you age faster.
Those massive spikes in your blood sugar essentially damage your
cells in your body through a process called
glycation, which accelerates the rate of aging in your joints, skin, organs, and even your brain.
A HgA1C test looks at the level of
glycation (indicative of blood sugar levels) in the red blood
cell over a 90 - 120 day period.
Life Extension Carnosine 500 mg prevents
glycation in the
cells to work as an antioxidant and deter the physical signs of aging.
Sugar is the number one cause of
glycation that can strip your
cells of their proper amino acids.
There are several possible sources of oxidative stress in diabetes including
glycation reactions, decompartmentalization of transition metals, and a shift in the reduced - oxygen status of the diabetic
cells.