In contrast, lymphocytes in both types of endothelial
cell grafts expressed higher levels of genes known to be involved in dampening the immune response and inducing self - tolerance.
Not exact matches
Lymphocytes in the
grafts of undifferentiated iPS
cells were also
expressing relatively high levels of genes known to be involved in hostile immune responses.
The fact that Connexin 30 knockout mice had a higher number of
grafted cells than normal mice, and that some of the
grafted cells expressed CONNEXIN 30 is a very important finding when considering
cell transplantation as a treatment for hereditary hearing loss caused by CONNEXIN deficiency.
However, the Connexin 30 knockout mice had more
grafted cells than the normal mice, and some of the
grafted cells were found to
express CONNEXIN 30.
While both eye fields and EFTF -
expressing pluripotent
cells generated epidermis, forebrain, and olfactory tissue when
grafted to the anterior neural plate, transplanted eye fields also formed muscle and head mesenchyme (Figure 4 and unpublished data).
(A — C) Control YFP -
expressing pluripotent
cells (YFP) form only epidermis when
grafted to embryos after removal of the endogenous (left) eye field.
We
grafted donor (YFP - only or EFTF / YFP -
expressing) pluripotent
cells to host embryos from which one of the two eye fields had been removed (Figure 3A and 3B).
Grafted human
cells expressed PMEL17 in vivo and could down - regulate Pax6 in the subretinal space, a hallmark of terminally differentiated RPE (Fig. 5D).