Sentences with phrase «cell hyperactivation»

ST2 contributes to T - cell hyperactivation and fatal hemophagocytic lymphohistiocytosis in mice.

By binding not only CD28 but also its coligand B7 - 2 directly, superantigens potently enhance the B7 - 2 / CD28 interaction, inducing thereby T - cell hyperactivation.

Not exact matches

By studying human cancer cells and animal models of cancer in the lab, our researchers have shown that loss of PTEN leads to high levels of PI (3,4) P2, which could result in hyperactivation of AKT.

Familial hemophagocytic lymphohistiocytosis type 2 (FHL2) is a cytokine storm syndrome characterized by immune hyperactivation with viral infection due to a CD8 T cell cytotoxic killing defect secondary to a perforin deficiency.

Pilar received her PhD in 2017 at the Complutense University of Madrid, where she studied immune cell dysfunction and hyperactivation in HIV / HCV coinfected patients, as well as the in vitro and in vivo activity of nanoparticles against HIV - 1 and HSV - 2 infections to prevent their transmission in humans as a topical microbicide.

Researchers generally attribute tissue thickening (and ensuing damage to small blood vessels) to hyperactivation of skin cells called fibroblasts.

In addition, many cancer cells express insulin receptors (IRs) and show hyperactivation of the IGF1R - IR pathway.

Often, living in a pernicious environment leads to hyperactivation of our immune gut cells and what would normally not cause an immune response, now does.