Sentences with phrase «cell identity»

"Cell identity" refers to the unique characteristics or features that define a specific cell. These characteristics can include the cell's structure, function, and specific genetic information, which differentiate it from other cells in the body. Full definition
How neural stem cell identity and potential is regulated over time has been poorly understood.
DNA binding proteins called transcription factors are required for maintaining cell identity.
Both define cell identity and are legitimate targets for treatment.
We are studying proteins called transcription factors that control skeletal cell identity and activity.
The epigenetic information ensures the spatial and timely organization of gene transcription that determines cell identity.
The daughter cell that stays put in the niche retains its stem cell identity.
These master regulators of cell identity include important developmental proteins, such as FOX and SOX families.
«This reflects how cells do not like to change from one specialized cell type to another and resist a change in cell identity,» said Pasque.
«Icebreaker» protein opens genome for T - cell development, researchers find: Study provides new view of immune cell identity, which can be harnessed to fight cancer, autoimmune disorders, and infectious diseases.»
This family comprises many members that have master roles in controlling cell identity and activity in many processes, from cell stemness to sex determination, heart formation, neurogenesis, and hematopoiesis.
Although the functional importance of TCF - 1 in T cells has been known for more than 25 years, the mechanism by which this protein controls T - cell identity remained unknown.
Using mutant zebrafish, the research team discovered that Jagged signals come from an unexpected cell type, endoderm - derived cells within the liver itself, stimulating duct cell identity in the liver.
His work cemented the concept of the master regulatory gene that could drive cell identity.
While levels of RNA and protein are strongly correlated when averaged over large numbers of cells, the authors discovered that this correlation breaks down at the level of single cells, with protein information more stably representing cell identity.
According to Diaz - Meco, when the researchers used an investigational drug that targets MDMs, they were able to prevent cancer progression in mice, and even restore normal pancreatic cell identity.
It aims to elucidate the roles of transcriptional regulators and chromatin structure in defining stem cell identity.
It is no longer debated that the chromatin structure is crucial to maintain cell identity, but the how remains.
MicroRNAs and long non-coding RNAs (lncRNAs) have the capacity to regulate gene expression programs, and their differential expression within immune cells highlights their potential in defining immune cell identity and function.
Thus, we provide a robust technology and the first comprehensive resource to address fundamental questions regarding maintenance of cell identity,» says associate professor Anja Groth, who is heading the laboratory.
«We have defined a new association of long non-coding RNAs with proteins called transcription factors that bind to specific DNA sequences and control cell identity and function,» Morrisey says.
Proteomics is an attempt to devise industrial - scale techniques to map the identity and activities of all the proteins in a cell
The team further treated mESCs with 4EGI - 1 for 3 days at which time the mESCs lost their stem cell identity.
«Our lab is interested in understanding how T - cell identity is established,» Vahedi said.
Senior author Golnaz Vahedi, PhD, an assistant professor of Genetics, brings her multidisciplinary training in computational biology, epigenetics, and immunology to bear on the question of T - cell identity.
The master regulator transcription factors and super-enhancers work together to regulate the expression of critical genes, such as those responsible for cell identity.
By controlling the transport of histones to our DNA, TLK and Asf1 ensure that the chromatin architecture and its information are copied correctly during cell division, so that cell identity is maintained,» explains Ilnaz Klimovskaia.
The Hippo pathway not only defines final tissue size by controlling developmental growth, but is also key to specifying stem cell identity and proliferation, to regeneration and tissue repair, as well as numerous cell fate decisions.
In the certain way you can imagine, or look at it like if you recall the epigenetic landscape of wanting that the valley gets deeper and deeper, and it gets more and more complicated to overcome the hill that then is building up and prevents to change the cell identity.
This classic work has inspired several generations of scientists to discover mechanisms of cell identity, which have informed a lot of the discoveries in stem cell biology and reprogramming that have followed.
In addition to activating this metabolic program, PPAR - delta also appears to turn on a set of genes that are important for stem cell identity, Yilmaz says.
The understanding of cell identity, heterogeneity and plasticity in neuroblastoma has strong implications with respect to the development of new therapeutic strategies to eradicate tumor cells in neuroblastoma patients.
June 2009 - The X factors of stem cells Ian Chambers and Simon Tomlinson review the transcription factor and pluripotency story so far Transcription factors are key proteins in cell identity.
A genome - scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity.
All of the cells in an organism contain the same DNA, but the epigenetic instructions encoded in specific DNA sequences give the cell its identity.
Consequently, the accelerated generation of stem cell lines is accompanied by confusion and duplication of cell line names and cell identities.
When they compared the expression profiles of genes related to stem cell identity, growth or differentiation between keratinocytes, fibroblasts, human embryonic stem cells (hESC) and KiPS cells, keratinocytes had more in common with hESCs and KiPS cells than with fibroblasts.
Cell identity is specified by the coordinated action of transcription factors, which bind to specific DNA regulatory sequences and turn gene expression on.
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