Sentences with phrase «cell imaging approach»

To pursue these studies, we employ Hi - C and ChIA - PET genomic technologies and single locus / live - cell imaging approach.

Not exact matches

Professor Richard Oreffo added: «Crucially, unlike current standard staining - based methods the stain-less imaging approach is translatable to the clinic as the stem cells are not harmed or disrupted in any way.

«The massive advantage with our stain-less laser - based imaging approaches is that you can use the stem cell sample without having to interrupt the developmental process in real time, you don't need to perform any cell disruption and there is no photobleaching (fading) which is fairly common with fluorescent material,» Catarina enthused.

Her PhD is focused on developing a novel label - free imaging approach for assessing human stem cells and skeletal regeneration non-destructively and non-invasively.

Earlier, for his Ph.D., he used his physics training to study biological interactions at the molecular resolution — but for his postdoc he changed approaches dramatically, turning to cell biology and applying his skills to the development of high - resolution functional imaging of DNA transcription in living cells.

Using a novel approach for imaging the movement of immune cells in living animals, researchers from the Massachusetts General Hospital (MGH) Center for Immunology and Inflammatory Diseases (CIID) have identified what appear to be the initial steps leading to joint inflammation in a model of inflammatory arthritis.

The approach thus has the potential to democratize super-resolution imaging throughout whole cells and tissues,» said Jungmann.

Gijs van der Schot, a Ph.D. student in the Department of Cell and Molecular Biology at Uppsala, will describe the researchers» new approach to imaging during the AVS 62nd International Symposium & Exhibition, held Oct. 18 - 23 in San Jose, Calif. «The X-ray laser we use for our work, the LCLS, is a fascinating machine — because of the physical principles behind it and the precise engineering of its parts — that produces very bright and ultra-short pulses,» he said.

The significance of the team's approach is that it «enables imaging of live cells in a high - throughput manner at a time resolution at which all biologically relevant dynamics appear static,» he said.

The speed, noninvasiveness, and high spatial resolution of this approach make it a promising tool for in vivo 3D imaging of fast dynamic processes in cells and embryos, as shown here in five surrounding examples.

In her presentation, Ann Tsukamoto, StemCells» vice president for research, said the company chose to test its neural stem cell approach on PMD because there is currently no treatment for the condition and a diagnosis can be confirmed by genetic testing and magnetic resonance imaging.

The optimized imaging ad behavior approach demonstrated that, in a selective group of Purkinje cells, calcium activity remained in a stable activation pattern over many weeks — a discovery that was only possible due to their optimized approaches.

Using a combination of molecular biology, biochemical and novel multi-dimensional digital imaging approaches we study in real - time complex multi dimensional signal integration during the interaction of T cells with live antigen - presenting cells.

He and his colleagues employ pharmacologic, brain imaging, epidemiologic, genomic, and cell model approaches to study schizophrenia and bipolar disorder, in particular.

These questions will be addressed by combining unbiased «omics» - approaches (i.e. genomics, transcriptomics, and proteomics) and a targeted genetic analysis with both superresolution live - cell imaging and electron microscopy of nanotube - forming cells.

We exploit chick and mouse embryo animal models, combined with live imaging, cell and tissue cultures and molecular approaches.

Using single - molecule imaging, super-resolution microscopy and various biophysical and molecular approaches she will explore how gene expression in living cells works.»

To this end, we are developing a new multi-scale live imaging approach to characterize nuclear organization dynamics at the single cell level based on the simultaneous characterization of both the local dynamics of RNA polymerases and transcription factors and the large scale behavior of chromatin.

For this we use gene replacement, live and fixed cell imaging, conditional localization and (in) activation approaches, proteomics, biochemistry and structural biology.

By applying biophysical techniques to elucidate the overall shape of ALC1 and combining these approaches with cell - based and live - cell imaging experiments, the authors of the article in Molecular Cell dissect the molecular mechanisms how the remodeling activity of ALC1 is controlled by its macro domcell - based and live - cell imaging experiments, the authors of the article in Molecular Cell dissect the molecular mechanisms how the remodeling activity of ALC1 is controlled by its macro domcell imaging experiments, the authors of the article in Molecular Cell dissect the molecular mechanisms how the remodeling activity of ALC1 is controlled by its macro domCell dissect the molecular mechanisms how the remodeling activity of ALC1 is controlled by its macro domain.

Our multidisciplinary approach includes transgenesis, real time imaging, multi-parameter flow cytometry, transcriptomics, RNA interference, proteomics and single cell methodologies.

We focus on squamous tissues, the skin epidermis and the lining of the oesophagus, using transgenic models, novel sequencing approaches, live imaging and single cell analysis to uncover key steps in cancer development, with aim of developing rational interventions to decrease cancer risk.

Modern Cytological Approaches Including Epitope Tagging and Imaging Yeast Cells Using Fluorescence Microscopy

The Dotiwala laboratory uses cellular, molecular, biochemical and omics approaches, as well as sophisticated in vivo imaging, to dissect the mechanism by which cell - based immunity (neutrophils, macrophages and killer lymphocytes) is activated in the presence of different pathogenic bacteria, such as intra - and extracellular bacteria, fungi and protozoa.

We employ a wide variety of state - of - the - art technologies such as in vivo optical imaging and high - throughput methods including cell - based screening, genomics, and proteomics approaches.

To come to a structural understanding of nuclear organisation, we will explore and further improve correlative imaging approaches, combining live cell confocal microscopy, super-resolution and electron tomography to unravel the structure and mechanisms of NPC assembly and disassembly.

We are studying chromatin organisation and compaction, as well as the 4D human genome architecture by correlative imaging approaches, including live cell imaging and various super-resolution techniques (figure 2).

For a systems - level understanding of all crucial protein interactions during cell division, we are combining automated single molecule calibrated imaging and computational data analysis with advanced machine learning and modelling approaches to build an integrated protein atlas of the human dividing cell.

The Innovator Award will enable Sipkins to continue to combine state - of - the - art imaging techniques, performed on living mice, with cell and molecular biology approaches to learn more about these stem cell niches.

Aim 3: We are specifically interested how defects of nuclear proteins cause axonal phenotypes using live cell imaging techniques, inhibitor studies, laser irradiation, - omics approaches.

We combine genetics, biochemistry and a broad spectrum of cell biological and imaging approaches to study:

The Metabolomics & Proteomics Technology Unit will offer localizomics approaches based on MS Imaging on tissue / organs slices (or on in - vitro cell cultures), either in targeted MS (i.e. drug and metabolites distribution) or in untargeted high resolution (HR) MS (metabolite profiling).

Diagnostics, cell replacement and protection, drug discovery, tissue engineering, non-invasive imaging, and many other approaches to disease diagnosis and clinical management are likely to be transformed by research in this area.

Experimental approach: To use patient - specific induce pluripotent cell models from a (i) storage disease (NCL), (ii) aggregate prone disease (ALS) and (iii) a disease with no aggregates but hyperexcitability (ChAc) combined with state of the art live cell imaging techniques, electrophysiology and biophysical tools (PIV, laser ablation for cortex tension measurements, AFM).