Sentences with phrase «cell imaging studies»
«Breakthrough in live - cell imaging studies could lead to innovative drugs for a variety of human diseases.»
https://www.sciencedaily.com/ Not exact matches
«There was this initial thought that [circulating tumor cells] are only present at late stage,» says Sollier - Christen, but she notes that in the past year, several studies using more sensitive techniques have found such cells much earlier in tumor development, even before the tumor becomes visible by conventional imaging techniques.
The latest in live - cell microscopy — multiphoton imaging, light - sheet techniques, and technology borrowed from Raman spectroscopy — allow researchers to study living cells in more detail with less effort.
Earlier, for his Ph.D., he used his physics training to study biological interactions at the molecular resolution — but for his postdoc he changed approaches dramatically, turning to cell biology and applying his skills to the development of high - resolution functional imaging of DNA transcription in living cells.
To better determine the role of specific chemoattractants in type III hypersensitivity, lead author Yoshishige Miyabe, MD, PhD, a research fellow in Luster's lab, used multiphoton intravital microscopy — an imaging technology pioneered for studies of immune cell movements in living animals by CIID investigator and co-author Thorsten Mempel, MD, PhD — to follow in real time the development of IC - induced arthritis in a mouse model of rheumatoid arthritis.
In a study presented in the featured clinical investigation article of the November issue of The Journal of Nuclear Medicine, they used 18F - fluorodeoxyglucose (FDG) PET / CT imaging to show that the amount of cell - free tumor DNA circulating in the bloodstream correlates with tumor metabolism (linked to cancer aggressiveness), not tumor burden (amount of cancer in the body).
Hwang said the study would provide data about the best candidates for active surveillance, and create a repository of imaging and cell samples to advance knowledge into the molecular biology of DCIS and what fuels or deters its growth.
Because calcium imaging is widely used to identify cells in tissues throughout the body, researchers studying other systems will be able to benefit from the published methodology.
The study, which was led by postdoc Gregor Pilz and PhD student Sara Bottes, used in vivo 2 - photon imaging and genetic labeling of neural stem cells in order to observe stem cell divisions as they happened, and to follow the maturation of new nerve cells for up to two months.
«We showed with this technique that we can detect very tiny tumors of just a few hundred cells,» Lu said, adding that the study pushed imaging boundaries, revealing smaller cancers than can be detected with current clinical imaging modalities.
But neither data from brain scanners — functional magnetic resonance imaging — nor clinical studies of patients with implanted electrodes have explained exactly how the cells in these face patches work.
Dr. Taraska's lab studies the structural cell biology of exocytosis and endocytosis with advanced imaging methods including live cell microscopy, superresolution fluorescence, and electron microscopy.
His work involves high - resolution imaging of chick embryonic tissue slices to study the cell - biological mechanisms driving neurogenesis in the spinal cord, for which Dr. Das played an instrumental role in pioneering new imaging technology.
Imaging flow cytometry (IFC) has emerged as a useful and efficient tool for studying the signaling pathways in immunophenotypically defined subpopulations of immune cells.
This study shows how these issues have been overcome with a newly developed imaging system, making it possible to image structures as small as 80nm or less anywhere in the cell.
The group of imaging specialists led by Prof. Michael Schäfers, Coordinator of the Cluster of Excellence, labelled the cells thus obtained with various fluorescent dyes in order to be able to study them in living organisms — initially with the optical method of fluorescence reflectance imaging.
The authors of this study combined live cell imaging with electron microscopy to observe Trichoplax feeding behavior at scales ranging from the whole animal to subcellular.
Exploratorium, San Francisco Study live specimens, like mouse stem cells as they progress toward becoming beating heart cells, at the high - resolution Microscope Imaging Station.
«This study is a great example of a highly collaborative endeavor that combines expertise in systems RNA biology, stem cell and neuronal biology, physiology, and cutting - edge imaging techniques.
The group combines several cutting - edge single molecule imaging techniques to study how protein organization, dynamics and stoichiometry relate to protein function in several fundamental biological processes, such as intracellular transport, autoimmune neurological disorders or stem cell reprogramming.
In a new study reported in Cell, an international group of plant biologists at ITbM, Nagoya University and other research institutes, have examined the ovules of plant cells by live - imaging to reveal a novel cell - elimination system based on an unusual cell fusCell, an international group of plant biologists at ITbM, Nagoya University and other research institutes, have examined the ovules of plant cells by live - imaging to reveal a novel cell - elimination system based on an unusual cell fuscell - elimination system based on an unusual cell fuscell fusion.
Invaluable as markers for monitoring photosynthesis and other energy - related processes in living cells, green fluorescent proteins (GFPs), discovered in a species of jellyfish, are vital in extremely high - resolution imaging studies.
In studying the functional behavior of the brain, from control of muscles to the formation of memories, scientists are using such tools such as electron microscopy, recordings of electrical signals from individual brain cells, and imaging of brain structures and processes using functional magnetic resonance imaging (fMRI), positron emission tomography (PET), and high - resolution optical imaging.
The LOCI lab specializes in developing new imaging techniques for living things, with a special interest in studying cells in their microenvironment rather than in isolation.
His laboratory currently applies high throughput imaging technologies to study trafficking between the endoplasmic reticulum and Golgi complex, and the internalization pathways taken by synthetic nanoparticles on exposure to cells.
Because metastasis is a complex process that has been difficult to study, Chicago's Ludwig Center will bring together researchers from various areas of expertise, including molecular biology, cell biology, genetics, bioinformatics, chemistry, imaging and medicine.
Current therapeutic options for such patients are limited, particularly when there are many metastases,» says Khalid Shah, MS, PhD, director of the Center for Stem Cell Therapeutics and Imaging (CSTI) in the BWH Department of Neurosurgery, who led the study.
Embryonic hemocytes lend themselves beautifully to live imaging studies since fluorescent probes can be expressed specifically in these cells using hemocyte specific promoters and their movements subsequently imaged within living embryos using confocal timelapse microscopy.
Using a combination of molecular biology, biochemical and novel multi-dimensional digital imaging approaches we study in real - time complex multi dimensional signal integration during the interaction of T cells with live antigen - presenting cells.
LOCATING PRE-HEMATOPOIETIC STEM CELLS Researcher: Fuchou Tang, Assistant Professor, Biodynamic Optical Imaging Center, Integrated Science Research Center, Peking University Project: In a study published in Nature, Tang and his collaborators isolated pre-hematopoietic stem cells (HSCs) for the first time and showed their unique transcriptome signatures before and during their maturation into HSCs (533:487 - 92, 2CELLS Researcher: Fuchou Tang, Assistant Professor, Biodynamic Optical Imaging Center, Integrated Science Research Center, Peking University Project: In a study published in Nature, Tang and his collaborators isolated pre-hematopoietic stem cells (HSCs) for the first time and showed their unique transcriptome signatures before and during their maturation into HSCs (533:487 - 92, 2cells (HSCs) for the first time and showed their unique transcriptome signatures before and during their maturation into HSCs (533:487 - 92, 2016).
He and his colleagues employ pharmacologic, brain imaging, epidemiologic, genomic, and cell model approaches to study schizophrenia and bipolar disorder, in particular.
To answer this question, a study presented at the AACR Annual Meeting 2018 used real - time, single - cell imaging to make movies of live cancer cells.
At the Kavli Institute for Brain Science at Columbia University Medical Center, researchers are developing novel imaging techniques to study this communication among brain cells.
We have two neurobiologists who are studying retinal ganglion cell and optic nerve biology — and that's me and Andy Huberman — and we also have two optical imaging engineers with very different backgrounds — and that's Vivek Srinivasan and Alf Dubra.
We also offer passive cell transfer studies, generation of bone marrow chimeras, in vivo imaging (IVIS), determination of the microbiome, and histopathology.
«Eggshells are notoriously difficult to study by traditional means, because they easily break when we try to make a thin slice for imaging by electron microscopy,» says McKee, who is also a professor in McGill's Department of Anatomy and Cell Biology.
15:00 Paolo Pinton, Section of General Pathology, Department of Experimental and Diagnostic Medicine, Telethon Center for Cell Imaging and Interdisciplinary Center for the Study of Inflammation, University of Ferrara, Italy: «Mitochondrial Ca2 + signals: message of life and death.»
But the development of new, high - resolution imaging technology able to capture single cells has finally enabled scientists to reliably chart noise at this level, and to study how it influences behavior.
Today, analyzing and editing genomes, proteomes and metabolomes has become a standard for many model systems; imaging beyond the diffraction limit of light and new technologies for studying protein structures provide insights deeper than ever before; the characterization of large populations of cells or organisms brings unprecedented statistical power; and studying nearly all organisms of an ecosystems as a whole allows generating comprehensive models.
3/24/2008 Non-Invasive Imaging Provides Window Into Genetic Properties of Brain Tumors Doctors diagnose and prescribe treatment for brain tumors by studying, under a microscope, tumor tissue and cell samples obtained through invasive biopsy or surgery.
Jin also believes that the novel X-ray imaging technique will facilitate the studies of other technologically important solid - state transformations and help to improve processes such as preparation of inorganic ceramics and thin - film solar cells.
Embryonic stem cells, Adult stem cells, Reprogramming to pluripotency and lineage conversion, Directed differentiation, Germ cells, Genetic and epigenetic mechanisms, Stem cells in development, Stem cell niche, Cancer stem cells, Disease modeling and drug screening, Stem cell therapy, Clinical studies in regenerative medicine, Tissue engineering and biomaterials, Imaging and diagnostics, Stem cell products, manufacturing, and quality control, Ethical, legal, and social issues Read Journal
We are studying chromatin organisation and compaction, as well as the 4D human genome architecture by correlative imaging approaches, including live cell imaging and various super-resolution techniques (figure 2).
Cell screening for functional analyses, transcriptomic studies and morphological studies together with imaging
«Deficient neuron - microglia signaling results in impaired functional brain connectivity and social behavior» Y. Zhan, R.C. Paolicelli, F. Sforazzini, L. Weinhard, G. Bolasco, F. Pagani, A. L. Vyssotski, A. Bifone, A. Gozzi, D. Ragozzino, C.T. Gross Nature Neuroscience 17 (3), 400-4006 (2014) «USPIO - loaded Red Blood Cells as a biomimetic MR contrast agent: a relaxometric study» A. Boni, D. Ceratti, A. Antonelli, C. Sfara, M. Magnani, E. Manuali, S. Salamida, A. Gozzi, and A. Bifone Contrast Media and Molecular Imaging 9, 229 - 236 (2014) «Distributed BOLD and CBV - weighted resting - state networks in the mouse brain» F. Sforazzini, A.J. Schwarz, A. Galbusera, A. Bifone, and A. Gozzi NeuroImage 87, 403 - 415 (2014) «Antimicrobial peptides design by evolutionary multiobject optimization» G. Maccari, M. Di Luca, R. Nifosì, F. Caldarelli, G. Signore, C. Boccardi, and A. Bifone PloS Computational Biology 9 (9): e1003212 (2013) «Differential effect of orexin - 1 and crf - 1 antagonism on stress circuits: a fMRI study in the rat with the pharmacological stressor yohimbine» A. Gozzi, S: Lepore, E: Merlo Pich, and A. Bifone Neuropsychopharmacology 38 (11): 2120 - 2130 (2013) «Water dispersal and functionalization of hydrophobic iron oxide nanoparticles with lipid - modified poly (amidoamine) dendrimers» A. Boni, L. Albertazzi, C. Innocenti, M. Gemmi, and A. Bifone.
Project: A Study of the Dynamics of Schlemm's Canal Endothelial Cells using a Three - dimensional Cell Culture Device with Real - time Imaging.
By imaging cancer cells in vivo, we are studying how cells migrate in and interact with complex environments in the living animal (Fig 2C).
«This is the first time the two imaging methods IF and FP have been combined to study the location of a large number of proteins in the cell in an efficient and systematic way», says Emma Lundberg, principal investigator and Director of the Subcellular Protein Atlas.
The lab studies the pathways from sensory input to behavioral output by quantitative analysis of behavior under well - defined conditions, genetic manipulation of animals or individual neuronal cells, and calcium imaging from neurons in living animals.
Now a research team led by Broad Institute Imaging Platform director Anne Carpenter and postdoctoral fellow Mohammad Rohban has shown that a high - throughput, computerized imaging technique for studying morphology, called Cell Painting, can provide insight into the cellular roles of genes or disease - linked gene alleles whose function or impact is uImaging Platform director Anne Carpenter and postdoctoral fellow Mohammad Rohban has shown that a high - throughput, computerized imaging technique for studying morphology, called Cell Painting, can provide insight into the cellular roles of genes or disease - linked gene alleles whose function or impact is uimaging technique for studying morphology, called Cell Painting, can provide insight into the cellular roles of genes or disease - linked gene alleles whose function or impact is unknown.