Sentences with phrase «cell immune responses»

Finally, we are exploiting our unique access to acute samples that blood banking offers, in order to characterize the B cell immune responses to many of these viruses.

Research Focus: My research project is focused on the characterization of human T cell immune responses against Dengue virus.

By blocking inhibitory molecules or, alternatively, activating stimulatory molecules, these treatments are designed to unleash or enhance pre-existing anti-cancer T cell immune responses.

[31] Recent studies show that the vaginal mucosa can support T - cell induction in the absence of MALT or secondary lymphoid tissues, suggesting that the type II vaginal mucosa can itself act as an inductive site for the generation of primary CD8 + T - cell immune responses.

When STAT3 was knocked out in a mouse model, researchers observed increased T - cell immune responses, suggesting a valuable therapeutic target.

T CD4 + cells are crucially important in generating protective cell immune responses and they are thought to be deregulated in multiple sclerosis.

These animals had severely reduced T and B cell immune responses.

After a person contracts chicken pox, they become immune to VZV, but it can re-activate in old age and cause shingles if T cell immune responses aren't strong enough.

Dendritic cells are essential for an effective T - cell immune response.

To do this, they vaccinated mice with a combination of two of the T. cruzi proteins (called TcG2 and TcG4), which they had shown to be the most potent in provoking both an antibody and a T - cell immune response.

«The idea basically is that a vaccine should induce antibodies T cells immune response, that would neutralise HIV in all of its forms,» explains Ulrich Fruth, vaccine development and evaluation team leader at the World Health Organisation, in Geneva, Switzerland.

Bavituximab's presumed mode of action is to block immunosuppression while activating a tumor - killing T - cell immune response.

Importantly, splenic titers of LCMV measured on day 7 postinfection are unchanged by immunization, indicating that despite functional enhancement in the CD8 T cell immune response, the virus is still not cleared by perforin - deficient mice that have been immunized (Fig. 2E).

The lab also found that apoptotic tumor cells serve as potent instigators of the T cell immune response and has worked on developing cancer vaccines to mimic PND tumor immunity.

Not exact matches

The company is developing a T - cell reprogramming technology designed to generate an anti-tumor response from the patient's own immune system.

The initial immune response involves cells of the body's innate immune system, such as macrophages and neutrophils.

IFM has two preclinical programs, which work to enhance the immune system's response to cancer cells.

The institute, which includes over 40 laboratories and more than 300 researchers, said the research would focus on modifying a patient's own immune system T - cells to target a tumor, studying ways to boost patient response to current immunotherapy drugs.

Since the cells are coming from someone else, the immune system could mount a response to kick out the new cells.

In December, SQZ partnered with global pharma firm and cancer treatment leader F. Hoffmann - La Roche in a deal that could be worth $ 500 million or more — a large undisclosed upfront payment, and additional sums when SQZ meets certain milestones — to speed up the development of its technology specifically to inject a person's immune cells with a protein to activate a «killer T» cell response to fight off cancer.

CRAC channels control the entry of calcium into immune and other cell types, and calcium is an important intracellular signaling molecule that modulates cytokine production and the immune response.

The company leverages its unique insights in cancer biology and the immune system to discover and develop novel oral small molecules that activate immune responses to eliminate cancer cells.

CAR - T approaches involve reengineering T - cells to find and destroy cancer cells, but that process can cause cytokine release syndrome (CRS), a life - threatening immune response NantKwest hopes to sidestep.

The tattooing process works by injecting ink into the skin, which stimulates an immune response in which cells called «macrophages» move into the area and «eat up» the ink.

Turnips are high in vitamins A and C; antioxidants that together play an important role in stimulating the body's immune response by boosting the formation of antibodies and white blood cells.

Beta - carotene has been found to reduce cell damage caused by free radicals, and improves immune function by enhancing cell mediated immune responses.

In addition, Red Star Nutritional Yeast contains other beneficial components, such as beta - 1,3 glucan and mannan, complex carbohydrates known to improve the immune response and help maintain cholesterol levels that are already within a healthy range; trehalose, a disaccharide that helps maintain the health of brain cells; and glutathione, an antioxidant that plays an important role in cellular defense mechanisms.

It also boosts the body's immune response against infections and cancer cells and plays an important role in thyroid function and fertility.

This vitamin also helps maintain cell membrane integrity and stimulate the immune response.

When it detects anything white blood cells flood her milk and therefore baby has an improved immune response.

Avoid foods and drinks with lots of sugar as sugar can interfere with immune response (white blood cells) for up to 6 hours after consumption.

CD4 cells (also known as T4 or helper T cells) are lymphocytes (a type of white blood cell), which are important in immune responses.

The introduction of infant formula to babies» diets changes the infants» gut microbiome, thus affecting the response of the infant immune system to pathogens.47 - 51 A greater amount of natural - killer cells, suggesting a more mature immune system, have been found in breastfed infants than in formula - fed infants.52 In addition, pH level in the stomach of breastfed children is better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death in tumor cells.51, 53

As the immune cells in the recipient recognize transplanted cells as foreign, they mount an inflammatory response that can lead to the body rejecting the transplant.

We found that when it comes to cutaneous immunity — specific to skin — the immune system was being obstructed by skin cells that were too prone to producing inflammation responses.

And using cells from someone other than the cancer patient being treated might trigger an immune response against the foreign cells.

An immune response, triggered by foreign neural stem cells, could actually help attack tumors, says Evan Snyder, a stem cell biologist at Sanford Burnham Prebys Medical Discovery Institute in San Diego, California, and one of the early pioneers of the idea of using stem cells to attack tumors.

Without this circulation, you'd lack any immune cells — and without an immune response, any exposure to everyday germs would prove fatal.

«We also showed that, once the NOD2 pathway trigger is initiated, the cells need a second, amplifying step to complete a full - strength immune response.»

Researchers found that NAD +, a natural molecule found in living cells, plants and food protects against autoimmune diseases by altering the immune response and turning «destructive» cells into «protective» cells.

«Inflammation occurs when our immune cells release inflammatory messengers, or cytokines, which is a normal response to disease.

The research, published and featured in the Spot Light section of the December edition of the Journal of Virology, examines a previously unknown connection between flaviviruses — a classification of viruses that include West Nile virus, Dengue virus and tick - borne encephalitis virus — and organelles (a specialized subunit within a cell) known as peroxisomes that help coordinate the body's immune responses.

«We're interrogating the tumor microenvironment,» she says, «by looking at suppressive cues as well as cells and secreted proteins that protect tumors from the immune response.»

The researchers found that the immune cells in the skin of this animal model generated large amounts of the cytokine IL - 17 — a protein of the immune system that activates cellular inflammation in response to damage.

To fend off HIV, researchers introduced one vaccine (ALVAC) to induce a T cell response — thereby alerting the immune system — and another (AIDSVAX) later to spur an antibody response.

When the team compared the types of immune cells activated in the fetus with those in the mother, there were clear differences, suggesting that fetuses generate an independent immune response to CMV (Journal of Experimental Medicine, DOI: 10.1084 / jem.20090348).

On its own, this immune response had no immediate effect in the fight against the utilized breast tumors, but in combination with the ADC it proved itself effective in attacking cancer cells in mice, resulting in the complete cure of the majority of mice receiving the combination therapy.

«These T - cells dampen incorrect responses of the immune system and have a strong anti-inflammatory effect.

Understanding how dendritic cells are created will aid scientists in finding ways to boost the immune response to infections or dampen it in autoimmune diseases such as lupus and rheumatoid arthritis.

«Similarly, triggering extra production of particular dendritic cells could improve the immune response to infections or vaccines.