This research will have a significant impact on understanding neoantigen - T
cell immunobiology and could improve the treatment prospects of pancreatic cancer patients.
Not exact matches
«This gut microbiota has been linked to the inflammation that triggers obesity, diabetes, metabolic disease, and most of chronic health problems of the Western World,» said Yale's Richard Flavell, Sterling Professor of
Immunobiology, Howard Hughes Medical Institute investigator, and co-senior author of the paper appearing Feb. 27 in the journal
Cell.
Department of
Cell Biology and Section of
Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, 333 Cedar Street, Post Office Box 208002, New Haven, CT 06520 — 8002, USA.
«Because we observed microbial effects mainly in the gut, we believe that a microbe - based therapy would avoid the collateral damage seen with drugs that wipe out classes of immune
cells across the body,» said Benoist, a professor of microbiology and
immunobiology at HMS.
«Preventing the degradation of MBD3 protein will make it difficult for myeloma
cells to escape this class of drugs,» said senior author Madhav Dhodapkar, professor of
immunobiology and chief of the Section of Hematology.
«In essence, OX40 activates the IL - 9 gene in T helper
cells, leading to the overproduction of IL - 9 through a powerful molecular machinery of super-enhancers that regulate gene expression,» says Dr. Xian C. Li, the director of the
Immunobiology & Transplant Science Center at Houston Methodist Research Institute.
Most T regulatory
cells develop and mature in the thymus, a small lymphatic organ above the heart, says Stephan Kissler, PhD, an Investigator in Joslin's Section on
Immunobiology.