Sentences with phrase «cell immunosuppression»

Not exact matches

Thus, this approach could prove useful to enhance the septic patient's T - cell - mediated immunity during the period of immunosuppression.

Although changes in treatment methodology still have to be studied, Dr. Cripe believes it may be that the timing of various treatments is what matters, and that perhaps initially suppressing immunity could allow the virus to infect a large number of tumor cells before relieving the immunosuppression to allow the body's own T cells to fight off the tumor.

Consequently, they hope that their results will «motivate the incorporation of assays measuring ex-vivo T - cell function into ongoing and planned clinical trials of HDAC inhibitors, and that immunosuppression will be considered as a potential factor limiting the effectiveness of any observed outcomes.»

This has potential applications for cell replacement without the immunosuppression treatments that are required when cells are transferred between genetically different individuals.

However, the use of NF - kB inhibitors in treating cancer is complicated by severe side effects related to immunosuppression caused by indiscriminate inhibition of NF - kB in normal immune cells.

Monitoring immune cell activity — including phenotyping immune cell subsets, tracking cell proliferation, and measuring cytokine production — can provide insights into the overall status of immune function in patients, particularly those undergoing immunosuppression after transplants, enduring cancer treatment, or suffering from autoimmune disease or other pathologies that affect the immune system.

«Based on our findings, we propose that timely and efficient therapies that target MAIT cells will likely benefit the patients by preventing uncontrolled inflammation and also by relieving immunosuppression,» said Haeryfar.

Understanding which cytokines are best for monitoring inflammation and immunosuppression, and knowing which are secreted by different immune cell types at each stage of maturation and activation, will provide essential insights into disease treatment options.

Based on their findings, the researchers want to find ways to selectively target immunosuppression in lung transplants, to encourage memory T cells to thrive while eliminating other T cells that harm transplanted lungs.

We want to understand how to use innate immune cells to reverse immunosuppression in the tumor microenvironment.

Bavituximab's presumed mode of action is to block immunosuppression while activating a tumor - killing T - cell immune response.

Conceptually, the antigen - specific enhancement of Treg cell function is of particular importance because such strategies will minimize the requirements for pharmaceutical immunosuppression, sparing desired protective host immune responses to infectious and malignant insults.

We have observed significantly better graft and patient survival in stem cell group vs. controls with additional benefits of minimization of immunosuppression.

PD - 1 is a receptor present on activated T cells, which mediates immunosuppression primarily in peripheral tissues, where PD - 1 ligands, PD - L1 and PD - L2 share an immunosuppressive activity and may be produced by either tumor cells or stromal / tumor - infiltrating immune cells.

His lab has made contributions in the area of tumor induced immunosuppression of dendritic cells, characterization of human myeloid derived suppressor cells, and the development of novel adjuvants for cancer vaccines.

Although all animals were maintained on an oral immunosuppression drug, ciclosporin, throughout the experiment, this was not sufficient to sustain iPS - RPE cell survival.

Thus, one can transplant fully allogeneic hematopoietic stem cells and co-transplant, for example, hearts from the hematopoietic stem cell donor to induce lifelong donor - specific acceptance of the transplant, without deleterious immunosuppression [4].

Prevention of allergic rhinitis by ginger and the molecular basis of immunosuppression by 6 - gingerol through T cell inactivation.

This results in cancer cells secreting large amounts of the fermentation product lactic acid into their extracellular microenvironment, lowering the extracellular pH to 6 - 6.5, contributing to acidosis, initiation of angiogenesis and providing a metabolic fuel for cancer cells, which also induces immunosuppression.

The infection can cause anemia (low number of red blood cells) and immunosuppression.

In some cases, cancer cells are able to reduce the ability of the immune system to respond (immunosuppression).

FeLV can cause cancer by directly promoting transformation of normal cells into cancerous cells, and by causing significant immunosuppression, which makes a cat more vulnerable to both infections and cancer.

Why do I keep reading so many other peoples lawsuits where they were «exposed» to toxic chemicals and have been «put at increased risk of having future health problems» while the toxic Manganese and Lead water I ingested injured my brain and caused permanent disability and life threatening Severe Immunosuppression with cell counts so low my teeth have fallen out and why have I not been able to get compensation for my toxic water injuries that I did not cause?