Sentences with phrase «cell impact development»

We investigate how changes to DNA organization within the nucleus of a cell impact development and disease.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Alternative protein sources may include the use of by - products currently viewed as waste or the development of new protein sources from plants, lower order animals, or single - cell organisms with a lower environmental impact compared with typical animal - based protein sources.

The elevation in a growing embryo's temperature, called hyperthermia, impacts the activity of heat - sensitive channels that are present in cells necessary for an embryo's development, researchers report online October 10 in Science Signaling.

New products and developments, such as new drugs for cancer, fresh therapies for rare diseases, progress in medications for HIV / AIDS, and advances in stem cell research had the greatest positive impact.

«If we can preserve these important cells, we may be able to decrease the negative impacts of traumatic brain injury,» said first author David Cantu, Ph.D., a postdoctoral scholar at Tufts University School of Medicine, and member of the NIH - funded Institutional Research Career and Academic Development Awards (IRACDA) Program, Training in Education and Critical Research Skills (TEACRS), at the Sackler School of Graduate Biomedical Sciences at Tufts.

Its scientists recently earned an award for the development of a Wavelength Scanning Interferometer, which has uses that include the detection of defects in the coating that can have a serious impact on the longevity of roll - to - roll vapour barrier coatings for flexible PV (photovoltaic) cells.

Thus, in utero nutritional exposures during critical windows of germ cell development can impact the male germline methylome, associated with metabolic disease in offspring.

In fact, associations of cancer cells with the normal peritumoral microenvironment can profoundly impact tumor growth and development.

This led to development of newer technology, called single cell sequencing (SCS), that has had a major impact in many areas of biology, including cancer research, neurobiology, microbiology, and immunology, and has greatly improved understanding of certain tumor characteristics in cancer.

It is the first time that evidence has been found to suggest that local anaesthetic could affect tooth cell growth and potentially impact upon tooth development.

In this webinar, a panel of experts will discuss their research and describe the use of real - time, label - free cell monitoring in their investigation of novel cancer targets and the impact of their work on translational research and drug development.

Another interesting finding was the impact of the antibody on CD4 + T cells, helper cells that promote the development of killer T cells called CD8 +, which target and destroy virus - infected liver cells.

«To understand the factors behind T - cell - receptor binding to peptides will have major impact on biomedical developments, including vaccine design and immunotherapy.»

Furthermore, since malignant cells exploit early developmental programmes for their survival and growth, a deeper understanding of human development will have impact in cancer research.

Of note today: non-exclusive breastfeeding increases the risk of HIV transmission via the alteration of gut microbiome / T - cell activation; Fasting altered the gut microbiome in beneficial ways but only in mice previously fed a high fat diet; An investigation into new species of the honey and bumblebee gut commensal genus Gilliamella; Catfish development shapes gut microbial community structure independent of diet; A metagenomic analysis of the skin microbiome of the frog, Craugastor fitzingeri; The microbiome is altered during the bioremediation of herbicide contaminated soil; The impact of urban density on the soil microbiome; A randomized placebo controlled clinical trial of a microbiota based drug for the prevention of Clostridium difficile Infection; and the virome of the Cuatro Ciénegas Basin of Mexico

The news comes at a time of emerging importance for the biological process called «epigenetics,» in which a non-genetic factor impacts a cell's genetic makeup early during development — but sometimes with longer - term consequences.

In particular, the scientists want to know more about how the vitamin influences the genetic programming of an embryo, which specific cells are impacted, and precisely how much retinoic acid is required for normal development.

While many important developments impacted the field, two that garnered significant public, political and scientific attention in 2016 were the proliferation of clinics using unproven stem cell «therapies,» and the steps forward in therapeutic modification of human oocytes (unfertilized eggs) through a process called mitochondrial replacement therapy (MRT).

Developing methods to deliver cells and to reduce contamination of hESC - derived product preparations are major concerns impacting the development and application of stem cell therapies,» said Emmanuel Baetge, Ph.D., Senior Vice President and Chief Scientific Officer of Novocell.

The project «Preprogrammed versus stochastic clonal evolution of relapsing Acute Myeloid Leukaemia: Impact on disease development and therapeutic responses» will dissect why the subpopulations of primary human blood cancer cells that drive leukaemic relapse resist relevant clinical treatments in vivo.

Early Childhood Expert Says Science Shows Impact of Early Experiences on Brain Development Journal Star, January 15, 2013 «Children are born with a certain number of brain cells, but the neural circuitry develops dramatically in the first years of life — and experiences affect how those connections are made, said [Professor] Jack Shonkoff, director of Harvard's Center on the Developing Child.»

Our collaborations have included conducting randomized controlled trials (RCTs) to evaluate the impact of high school curriculum supplements on cell biology and epigenetics, and documenting the process of curriculum and assessment development for a National Science Foundation Discovery Research K - 12 project on evolution and common ancestry.

«Low - cost, compact, flexible and efficient solar cells are destined to impact all sorts of Department of Defense applications, as lightweight solar panels will eventually power all kinds of equipment, particularly in remote, inaccessible areas,» said Dr. Michael Scalora, a research physicist at the U.S. Army Aviation and Missile Research, Development and Engineering Center.

Samsung drove the Indian mobile showcase with 23 rates impact to 8 percent continuous development took after by Lenovo Amass (counting Motorola) at second place with 9.6 percent share of cell phones in the second from last quarter of this current year, IDC said.