CD disease causes day blindness due to degeneration of the retinal «cones» — cone -
shaped cells in the retina that respond primarily to bright daylight.
A second type
of cell in the retina, the «rods» — rod - shaped cells that respond primarily to dim light and detect movement — are not involved in this disease.
An additional surprise was that the differentially expressed proteins were present not only in photoreceptor cells but also in
other cells in the retina, including horizontal and Müller cells.
The genetic disorder, prcd - PRA, causes
cells in the retina at the back of the eye to degenerate and die, even though the cells seem to develop normally early in life.
«We were lucky to be able to identify a gene and are very excited that the same gene seems to be a marker of stress to
ganglion cells in the retinas of mice, rats and humans,» Ban said.
In 2013, Sieving launched the NEI's Audacious Goals Initiative to fund research on restoring vision by regenerating
damaged cells in the retina.
In this case, light rays from the candlestick stimulate the
sense cells in the retina and release excitations which run to the visual center of the forebrain.
A fault in the CHM gene causes choroideremia, in which
cells in the retina stop working and slowly die, leading to blindness.
The number of damaged and
dying cells in the retina — a light - sensitive layer of nervous tissue in the eye — did not change in the castrated males.
Apte and Ban don't believe that the molecule
causes cells in the retina to die; rather, that it is a marker of stress in retinal cells.
It was also my impression that there was greater interest this year at ARVO in neuroprotection and the roles of the other
support cells in the retina.
The GABA receptor is in abundance on certain
cells in the retina on sunny days, and enhances the ability to see details and edges of objects.
But in the females without ovaries,
fewer cells in the retina died and the number of activated microglia within the tumors was also decreased.
Neuroscientists usually explain color illusions in mechanistic terms: They arise because of the
way cells in the retina and the brain respond to certain wavelengths of light.
Light intensity is detected by
special cells in the retina and this information is relayed to the internal body clock, located deep in a part of the brain called the suprachiasmatic nucleus.
Nathans is a neuroscientist who studies
how cells in the retina — the light - absorbing structure at the back of the eye, which is considered part of the brain — assume their correct identities, and how those cells respond to injury and disease.
Bypassing damaged retinal cells The light - sensitive photoreceptors made by the rod and cone
cells in the retina also belong to the GPCR class.
Previous work done by Swaroop and his colleagues showed that a transcription factor called NRL
pushes cells in the retina toward maturing into rods by suppressing genes involved in cone development.
The researchers identified a transcription factor called POU6F2, which is found in developing
nerve cells in the retina and corneal cells in mice.
In theory, Apte said, when most of the ganglion
cells in the retina already have died, fewer cells would be under stress, and that could mean lower levels.
The research demonstrates that bioactive lipids have the ability to regulate inflammatory
immune cells in the retina, key regulators of the angiogenic process in this disease.
Other research has shown that oxygen -
deprived cells in the retina produce a type of protein called vascular endothelial growth factor (VEGF), which triggers the growth of new blood vessels in the retina.
Opsis Therapeutics is a company that is developing technology to replace
degenerated cells in the retina to restore vision in people with Stargardt's disease.
Using a series of physiological tests, they showed that vasopressin -
expressing cells in the retina are directly involved in regulating circadian rhythms.
Using this technique, he discovered that direction selectivity is computed locally in individual dendritic branches of starburst
amacrine cells in the retina.
LCA is a rare inherited eye disease that destroys vision by killing photoreceptors — light - sensitive
cells in the retina at the back of the eye.
As the mutant rhodopsin protein kills light - sensitive
rod cells in the retina, the sufferer first loses night vision, then peripheral vision, and finally central vision when the lack of rod cells causes the color - sensitive cone cells to degenerate.
For this reason, Lin reckons the first use for the technique would be in reactivating
damaged cells in the retina, which naturally absorb light.
The condition is hereditary or age - related, and causes degeneration of the photoreceptors — light -
sensitive cells in the retina — leading to blindness.