Sentences with phrase «cell infiltration»
"Cell infiltration" refers to a situation where cells enter or invade a specific area or tissue in the body. It describes the act of cells spreading into places where they are not normally found. Full definition
These grafts showed preservation of the muscle architecture and lack of mononuclear cell infiltration in the syngeneic and tolerant grafts, but massive tissue destruction in the acutely rejected control grafts.
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In this study, immune cell infiltration of the lungs increased, and Th2 responses became more prominent.
«This is the first identified cell - intrinsic cancer - causing pathway that disrupts T cell infiltration in melanoma,» said study author Thomas Gajewski, MD, PhD, professor of medicine and pathology at the University of Chicago.
Mock - infected control (A); Severe hemorrhage and regression of ovarian follicles (B); Spleens from mock - infected control (left) and enlarged spleens from the infected ducks (C); HE - stained ovary section showing hemorrhage and follicle rupture with red stained bodies (D); HE - stained brain section revealing lymphocytes and mononuclear cell infiltration under cranial arachnoid (E) and focal gliosis (arrow)(F).
Inflammatory cell infiltration of pancreatic islets occurs in 46 % of diabetic dogs (83), and ∼ 50 % of diabetic dogs have circulating antibodies against β - cells (70 — 72).
These may be injuries over the cornea, infections in ophthalmic tissues, inflammatory cell infiltration into a transparent eye medium and degeneration of the cornea or the lens of the eye.
The investigators also found that there was a decrease in blood vessels and lymphocytic cell infiltration, both in AA98 - treated and V1q - treated mice, whereas a more significant decrease was observed in the combination treatment group.
Dr. Elizabeth Allen and colleagues from the group of Prof. Dr. Gabriele Bergers at the VIB - KU Leuven Center for Cancer Biology provide evidence that anti-PD-L1 therapy can sensitize and prolong efficacy of anti-angiogenic therapy, and conversely, anti-angiogenic therapy can improve anti-PD-L1 treatment specifically when intratumoral HEVs are generated that facilitate enhanced whire cell infiltration, activity and tumor cell destruction.
In addition, the researchers reported that MMP - 3 induced blood cell infiltration and hemorrhage after SCI in wild - type mice, but not in Mmp3 knockout mice.
IgA plasma cell infiltration of proximal respiratory tract, pancreas, kidney, and coronary artery in acute Kawasaki disease
Increased T - cell Infiltration Elicited by Erk5 Deletion in a Pten - Deficient Mouse Model of Prostate Carcinogenesis.
And that can drive a lot of B cell infiltration.
In a compression model induced by applying an aneurysm clip to the spinal cord in mice repeated PEA administration (10mg / kg i.p., 6 and 12h after SCI) significantly reduced the degree of the severity of spinal cord trauma through the reduction of mast cell infiltration and activation.
However, LBH589 was shown to worsen GVHD by elevating Th1 cytokines in recipient serum and enhancing CXCR3 expression on donor T cells and T cell infiltration in the liver (27).
Here we present a novel human Airway Lung - Chip containing a fully - differentiated human mucociliary airway epithelium separated from a pulmonary microvascular endothelium by a semi-permeable membrane that allows for immune cell infiltration.
Histopathologic examination of muscle biopsies revealed multifocal areas of mixed mononuclear cell infiltration, myonecrosis and regeneration.
Astaxanthin has been shown, when take in concordance with other carotenoids, to protect against free radical induced DNA damage, repair UVA - Irradiated cells, and inhibit inflammatory cell infiltration.
«We believe the key step is the initial, and very rapid, cell infiltration.
«In this study we found that NF - κB activity is strongly associated with immune system T - cell infiltration in lung cancer,» explained study co-author Dung - Tsa Chen, Ph.D., member of the Biostatistics Department at Moffitt.
Blame for treatment failures is usually attributed to so - called «cold» tumors, those that do not attract T - cell infiltration and may lack key T - cell targets — the mutated proteins known as neoantigens.
Pre-treatment neutrophil - to - lymphocyte ratio is associated with neutrophil and T - cell infiltration and predicts clinical outcome in patients with glioblastoma.
Forty - nine percent of the tumors that blocked T cell infiltration had high levels of beta - catenin signaling, including increased expression of six genes that are targets of beta - catenin.
PEGylated arginine deiminase can modulate tumor immune microenvironment by affecting immune checkpoint expression, decreasing regulatory T cell accumulation and inducing tumor T cell infiltration.
The study also demonstrated that at the highest dose, DG031 lowered levels of sICAM - I, a critical molecule in the activation of inflammatory cells and cell infiltration.
Phase II CALM extension study: Coxsackievirus A21 delivered intratumorally to patients with advanced melanoma induces immune - cell infiltration in the tumor microenvironment.
Nevertheless, certain histologic features of chronic bronchial disease are characteristic and include goblet cell hypertrophy and hyperplasia, mononuclear cell infiltration, and increased connective tissue within the lamina propria.