Sentences with phrase «cell infiltration of»

Inflammatory cell infiltration of pancreatic islets occurs in 46 % of diabetic dogs (83), and ∼ 50 % of diabetic dogs have circulating antibodies against β - cells (70 — 72).

IgA plasma cell infiltration of proximal respiratory tract, pancreas, kidney, and coronary artery in acute Kawasaki disease

In this study, immune cell infiltration of the lungs increased, and Th2 responses became more prominent.

Not exact matches

Further investigations showed that the mutation causes reduced CTLA - 4 function, which led to increased infiltration of the intestinal mucosa by T - cells and therefore to chronic diarrhea.

Yu said the impairment of sensory nerve regeneration in diabetic corneas is due to decreased ciliary neurotrophic factor, as evidenced by the fact that dendritic cells express ciliary neurotrophic factor (CNTF) in normal and healing corneas but decrease in diabetic corneas due to the reduced infiltration of dendritic cells.

Once Hartgerink and his team started to investigate the phenomenon, they found that even without additives their MDP is rapidly infiltrated by host cells, provokes a temporary inflammatory response, does not develop a fibrous capsule, supports the infiltration of a mature vascular network and recruits nerve fibers.

That reaction results when a localized accumulation of immune complexes — antibodies bound to their antigens — is deposited in tissue and sets off an inflammatory response involving the infiltration and activation of immune cells, initially the neutrophil.

«In this study we found that NF - κB activity is strongly associated with immune system T - cell infiltration in lung cancer,» explained study co-author Dung - Tsa Chen, Ph.D., member of the Biostatistics Department at Moffitt.

Using tumor biopsies from melanoma patients, the researchers could show that there is a positive correlation between the production of CCL5 and the infiltration of NK cells.

Heart tissue from that individual revealed infiltration of white blood cells called eosinophils.

In their newly published study, the researchers aimed to investigate the effect of blocking autophagy on the infiltration of NK cells in melanoma.

When CCL5 is depleted, the infiltration of NK cells and the subsequent regression of tumor volume were no longer observed, thus confirming the crucial role of CCL5 in driving NK cells into autophagy - defective tumors.

However, tumor cells can circumvent this immune defense by establishing a surrounding microenvironment that prevents the infiltration of NK cells and thus promotes tumor survival and growth.

In addition, older tissues tend to exhibit more chronic inflammation — a low - level infiltration of immune cells and substances.

Professor Aoki says, «By controlling the intercellular transmission of ERK activity in the future, it may be possible to suppress the infiltration of cancer cells.»

To explain their findings, the authors suggest that resveratrol's vasodilating effects via endothelial cells might enhance infiltration of inflammatory cells into the central nervous system, which in turn might play a key role in the pathogenesis of MS.

Both the number and activity of osteoblasts — cells that produce and reshape bone tissue — were increased within the bone marrow of mice with lung tumors compared with cancer - free animals; and reducing the number of osteoblasts in mice not only limited neutrophil infiltration of tumors but also interrupted tumor progression.

Cortisone helps to enhance the barrier function of the endothelium, preventing vascular leakage and further infiltration of the alveolar space by immune cells.

One third of these mice developed severe hepatic steatosis (infiltration of liver cells with fat), neutrophil infiltration, and necrosis, similar to that seen in patients with alcoholic hepatitis.

Despite the increased production of proinflammatory molecules, infiltration of adipose tissue by inflammatory cells has not been described as a common feature of obesity.

With respect to biological applications, the group is focusing on how cellular heterogeneity and cell - to - cell communication drive ensemble - level decision - making in the immune system, with an emphasis on «two - body» interaction (e.g., host cell - virus interactions, innate immune control of adaptive immunity, tumor infiltration by immune cells).

To that end, Sharma gave an overview of MD Anderson's efforts to comprehensively characterize the activity of the immune cells in the patients they treat, and they've already analyzed over 42,000 tumor tissue samples, from both before and after treatment, looking for clues regarding how treatment outcomes relate to immune cell infiltration into tumors.

Histopathology in Tg197 mice is characterized by infiltration of inflammatory cells, synovial hyperplasia, articular cartilage destruction and bone erosion symptoms, closely resembling those of human rheumatoid arthritis.

ADCC / ADCP - enabling isotypes of a-TIGIT surrogate Ab show potent monotherapy efficacy in murine tumor models that correlates to increased T cell activation and reduced Treg infiltration of tumors.

In ligase deficient mice, growth of mouse melanoma cells in vivo is attenuated, while tumor infiltration by CD4 + / CD8 + T cells and dendritic cells is increased.

«This is the first identified cell - intrinsic cancer - causing pathway that disrupts T cell infiltration in melanoma,» said study author Thomas Gajewski, MD, PhD, professor of medicine and pathology at the University of Chicago.

Moreover, the increase in leukocyte infiltration is most striking when considering the total numbers of CD4 and CD8 T cells, providing further evidence for a T cell - mediated immune response in the brain and / or meninges following infection with attenuated Type I parasites (Figure 3F).

Scoring - 0 - no definite pathology, 1 - mild peribronchiole and perivascular cellular infiltration, 2 - moderate peribronchiole and perivascular cellular infiltration, 3 - severe peribronchiolar and perivascular cellular infiltration with thickening of alveolar walls, alveolar infiltration and bronchiole epithelial cell necrosis and debris in the lumen.

Figure 2: Representative histology images of A: wild type and B: Tg197 animals at 7 weeks of age depicting the symptoms of Infiltration of inflammatory cells, Synovial hyperplasia, Articular cartilage destruction and Bone erosions evident as Tg5453 arthritic pathology.

Increased T - cell Infiltration Elicited by Erk5 Deletion in a Pten - Deficient Mouse Model of Prostate Carcinogenesis.

In the vaccine comparison experiment, lung lesion scores for histopathology were graded for individual animals on a scale of 0 to 4 where 0 — 2 represented degree of cellular infiltration and 3 — 4 represented the degree of bronchiolar epithelial cell necrosis and airway cellular debris (figure 2A).

Scoring 0 - no definite pathology, 1 - mild peribronchiole and perivascular cellular infiltration, 2 - moderate peribronchiole and perivascular cellular infiltration, 3 - severe peribronchiole and perivascular cellular infiltration with thickening of alveolar walls, alveolar infiltration and bronchiole epithelial cell necrosis and debris in the lumen.

The infiltration of Th1 and Th17 cells into GVHD target organs (liver and lung), as well as the serum level of related cytokines, also were increased in allogeneic BMT recipients.

Moreover, the infiltration of Th1 and Th17 cells into GVHD target organs, as well as the serum level of proinflammatory cytokines, were significantly decreased.

Added to this is the fact that white fat also damages the hematopoietic stem cells of bone marrow which could results in reduced blood cell formation in bone with excess fatty infiltration.

Mock - infected control (A); Severe hemorrhage and regression of ovarian follicles (B); Spleens from mock - infected control (left) and enlarged spleens from the infected ducks (C); HE - stained ovary section showing hemorrhage and follicle rupture with red stained bodies (D); HE - stained brain section revealing lymphocytes and mononuclear cell infiltration under cranial arachnoid (E) and focal gliosis (arrow)(F).

The study also demonstrated that at the highest dose, DG031 lowered levels of sICAM - I, a critical molecule in the activation of inflammatory cells and cell infiltration.

Firstly, invadopodia - like protrusions form at the ventral surface of invasive cells; later, one protrusion elongates that lastly drives the infiltration of cells into the underlying compartment.

Calcitonin Gene - Related Peptide Enhances the Expression of Signaling Molecules of the Wnt 7b / Beta - Catenin Pathway in Rat Type II Alveolar Epithelial Cells Under Hyperoxia Hyperoxic lung injury is characterized by epithelial cell death and leukocyte infiltration / inflammation in the lung.

These grafts showed preservation of the muscle architecture and lack of mononuclear cell infiltration in the syngeneic and tolerant grafts, but massive tissue destruction in the acutely rejected control grafts.

Types 1 and 2, the intermediate lesions, have infiltration of tissues with white blood cells, which is called intraepithelial lymphocytosis (IEL).

So we'll make sure there's a lot of other cofactors coz when you give iodine, it can spit out hydrogen peroxide, which can increase D cell lymphocyte infiltration into the thyroid.

(1) In a related study, Centipeda demonstrated effectiveness against ragweed pollen model by regulating the infiltration of eosinophil and mast cell proliferation.

These cells could be larger in response to lipid infiltration since the livers of the low protein group were observed to be very fatty.

And that can drive a lot of B cell infiltration.

Unfortunately, by ditching the high ground in favor of not - especially - convincing theatrics, the potency of the film becomes diluted to the point where we're viewing the infiltration of these secret cell groups as a fantasy, and therefore don't buy many of their tactics and plausible enough to keep us on the same edge we'd be teetering on if we felt the authenticity through and through.

The most common cause of inadequate tear secretion is the infiltration of inflammatory cells from the immune system into the cells of the lacrimal gland.

Live adult HW cause direct mechanical irritation of the intima and pulmonary arterial walls, leading to perivascular cuffing with inflammatory cells, including infiltration of high numbers of eosinophils.

The most common type of IBD is characterized by an infiltration of lymphocytes and plasmacytes cells.

INFLAMMATORY BOWEL DISEASE (IBD) The inflammatory bowel diseases (IBD) are the most common causes of chronic vomiting and diarrhea in dogs, and refer to a group of idiopathic, chronic gastrointestinal tract disorders, characterized by infiltration of the lamina propria by lymphocytes, plasma cells, eosinophils, macrophages, neutrophils, or combinations of these cells.12 The diagnosis of IBD requires the comprehensive exclusion of potential causes of gastrointestinal inflammation, including intestinal parasites, small intestinal bacterial overgrowth, bacterial enterocolitis, dietary intolerances or allergies, and neoplasia.12 Failure to eliminate known causes of gastrointestinal inflammation which can mimic IBD can result in frustration for the owner and clinician due to poor responsiveness of the animal to dietary or pharmacologic therapy.