Sentences with phrase «cell injury in»

An increase in ALT is highly specific to liver cell injury in dogs and cats.

Topics such as the mechanisms of cell injury in normal and dystrophic muscle, compensatory muscle regeneration and hypertrophy, and the effects of various therapies or voluntary exercise on muscle repair, satellite cell activation, muscle growth, bone density and age - related atrophy are examined using a large variety of cellular, molecular and whole - animal in vivo assays of function.

Not exact matches

According to the report, the team member who went in to the brothel as a decoy customer was beaten and robbed of his cell phone and cash, but escaped with the girl without further injury.

Such embryo research might teach us more about cell differentiation and early embryo development, it might make possible greater success in bone marrow transplants, and it might help us to treat more successfully degenerative diseases and spinal cord injuries.

In addition, affected individuals may heal slowly from injuries or have frequent infections due to the loss of normal white blood cells that fight infection.

The study, «Polarity of varicosity initiation in central neuron mechanosensation,» which will be published June 12 in The Journal of Cell Biology, observes the swelling process in live cultured neurons and could lead to new ways of limiting the symptoms associated with concussive brain injuries.

Jaundice which is due to the rapid, abnormal destruction of the baby s blood cells often resulted, in the past, in serious injury or even death for the baby, but this is different from what most babies are now experiencing.

LC - PUFAs are thought to be important for cognitive development because they are required for efficient neurotransmission (22) and are involved in neurite outgrowth, dendritic arborization, and neuron regeneration after cell injury (23).

Cord blood stem cells can be used to treat dozens of diseases and are being tested in FDA - regulated clinical trials to help people with autism, brain injury, and other conditions.

The Regenerative Research Foundation in Rensselaer, an affiliate of the Neural Stem Cell Institute, will receive nearly one - fifth of the funds, or almost $ 1.1 million, for work aimed at promoting spinal cord regeneration after injury.

Most groups have focused on detecting proteins released from dying brain cells, but those proteins are not always abundant after injury and often require exotic or proprietary antibodies to measure, said study corresponding author Adam Chodobski, associate professor (research) of emergency medicine in the Alpert Medical School of Brown University.

They discovered that in the young, more immune cells called monocytes were recruited to the lungs, and that the gene expression profiles of these cells had more inflammatory features, causing greater inflammation and more severe lung injury.

We're pretty good at taking cells in isolation and being able to understand, at least in part, their response to injury.

The decision was seen as an effort to mollify the religious fundamentalists at the core of Bush's political support who are ideologically opposed to deriving the cells from frozen embryos in fertility clinics and scientists and patients who hope that the cells could be used to help patients with Parkinson's, Alzheimer's, spinal - cord injuries, and diabetes.

Large quantities of these reverted cells could be used to treat anything from spinal cord injury to liver damage without the risk of tissue rejection, said Robert Weinberg, a biologist at the Massachusetts Institute of Technology's Whitehead Institute for Biomedical Research and co-author of a study appearing in Cell.

In the new study, Zigmond and colleagues found damaged nerve cells produce a stream of molecular lures that specifically attract neutrophils to injury sites in micIn the new study, Zigmond and colleagues found damaged nerve cells produce a stream of molecular lures that specifically attract neutrophils to injury sites in micin mice.

Immune cells are normally associated with fighting infection but in a new study, scientists have discovered how they also help the nervous system clear debris, clearing the way for nerve regeneration after injury.

This knowledge is important, as iPSCs hold great promise in the field of regenerative medicine, as they can provide a single source of patient - specific cells to replace those lost to injury or disease.

«There are currently no therapies which successfully reverse the damage seen in the more than 12,000 individuals who suffer a spinal cord injury each year in the United States alone,» says Dr. Richard G. Fessler, professor of neurological surgery at Rush University Medical Center and principal investigator for the Phase 1 clinical trial involving AST - OPC1 (oligodendrocyte progenitor cells).

Discovered in 2005, Th17 cells are thought to have a part in triggering the inflammation and tissue injury associated with autoimmune diseases.

When RCGD 423 was applied to joint cartilage cells in the laboratory, the cells proliferated more and died less, and when injected into the knees of rats with damaged cartilage, the animals could more effectively heal their injuries.

However, Stephen Back, a neurologist at the Oregon Health and Science University in Portland, points out that there is not yet proof that myelin - producing cells are stuck in arrested development in infants with brain injuries, although this has been shown both in mice and in adults with multiple sclerosis.

Disease or an injury to the retina also can cause the loss of protective proteins in the cells, resulting in additional cell death.

Dr. Llovet and colleagues demonstrated that the expression of mutant IDH in the adult liver of genetically engineered mice impairs liver cell development and liver regeneration — a process in which the liver responds to injury — and increases the number of cells to form a tumor.

But in disease conditions like muscular dystrophies, satellite cells can't keep up with repeated cycles of injury and are ultimately exhausted or functionally impaired,» Hindi said.

«Human stem cells treat spinal cord injury side effects in mice.»

They then argue that «By creating a financial incentive for embryonic stem cell research — an incentive that by NIH's own admission involves investments of «hundreds of millions of dollars» — and by specifying the precise means by which embryos must be destroyed in order to qualify for federal funding, the NIH necessarily and knowingly subjects embryos to a substantial risk of injury or death.»

Studying mice with injuries to the lining of the stomach, the researchers blocked the animals» ability to call on stem cells for help in the stomach.

The findings suggest that damage to brain cells called interneurons disrupts neurotransmitter levels and plays a role in the development of epilepsy after a traumatic brain injury.

The research, published in the current issue of the journal Science, demonstrates that brain cells, known as astrocytes, which play fundamental roles in nearly all aspects of brain function, can be adjusted by neurons in response to injury and disease.

«If we can preserve these important cells, we may be able to decrease the negative impacts of traumatic brain injury,» said first author David Cantu, Ph.D., a postdoctoral scholar at Tufts University School of Medicine, and member of the NIH - funded Institutional Research Career and Academic Development Awards (IRACDA) Program, Training in Education and Critical Research Skills (TEACRS), at the Sackler School of Graduate Biomedical Sciences at Tufts.

Encased in bone and protected by a special layer of cells, it is shielded from infections and injuries — but also from many pharmaceuticals and even from the body's own immune defenses.

«New cell type is implicated in epilepsy caused by traumatic brain injury.»

Astrocytes are star - shaped cells in our brain that surround brain neurons, and neural circuits, protecting them from injury and enabling them to function properly — in essence, one of their main roles is to «baby - sit» neurons.

In humans, the goal of SCNT is «nonreproductive cloning» — making embryos, then removing stem cells from the embryo and cultivating them to grow into tissues that could cure diseases, replace organs and heal injuries.

Together, studies in zebrafish and mammalian models could inform new ways to manipulate glial cells after human spinal cord injury.»

Zebrafish in which ctgfa was disabled had glial cells that often failed to extend into the lesions, and the fish were unable to recover from spinal injury.

A person with spinal injuries today went down in history as the first to receive a treatment derived from human embryonic stem cells (hESCs).

Working in Morrison's Neurotrauma and Repair Laboratory at Columbia Engineering, the team developed a blast injury model using a shock tube and custom - designed sample receiver to simulate a primary blast event and applied it to an isolated, living model of the BBB that consisted of brain endothelial cells.

«Proper blood cell production is dependent on functioning hematopoietic stem and progenitor cells that are destroyed during conditioning procedures for transplantation or following bone marrow injury,» said the study's first author Kevin A. Goncalves, who performed this research as part of his PhD studies in cellular and molecular physiology at the Sackler School.

The treatment not only led the spinal cord cells to produce and secrete ChABC in large quantities over areas spanning the injury epicenter, it helped to maintain the overall health of the damaged spinal cord and restored hind limb function in the animals within 12 weeks.

Adding a drug that blocked the calcium wave prevented microglia from migrating to the injury site, the team reports today in Developmental Cell.

Yonju Ha, a lead author of this article, said that further studies on this receptor and its role in white blood cell recruitment following tissue injury may aid in the development of new interventions for diseases associated with nerve injury, such as TON, stroke, diabetic retinopathy and glaucoma.

Excessive or uncontrolled inflammation can actually make injuries worse and contribute to disease in a couple of different ways — by activating cell death processes, clogging and rupturing blood vessels and producing toxic molecules like free radicals.

With no way for the cells between the brain stem and spinal cord to regenerate or reconnect, the injury often results in the permanent inability to empty the bladder.

Additional analysis revealed that ChABC gene therapy changed the way that inflammatory cells in the region respond following injury.

In May 2005, Hwang and his colleagues reported that it had produced 11 new human embryonic stem (ES) cell lines that carried the genetic signature of patients with diabetes, spinal cord injury, or a genetic blood disorder (Science, 20 May, p. 1096).

When a spinal cord injury takes place, extensions of nerve cells from the brainstem — the region of the brain where the command and coordination for urination takes place — become disconnected from cells in the spinal cord that control the muscles that squeeze or relax the bladder and open and close the urethra.

In the current study, Yu - Shang Lee, PhD, of the Cleveland Clinic, together with Jerry Silver, PhD, of Case Western Reserve Medical School, and others, used a chemical that promotes cell growth along with a scar - busting enzyme to create a more hospitable environment for the nerve graft at the injury site.

Delivering a single injection of a scar - busting gene therapy to the spinal cord of rats following injury promotes the survival of nerve cells and improves hind limb function within weeks, according to a study published April 2 in The Journal of Neuroscience.